Oralbiotica/Oralbiotics: The Impact of Oral Microbiota on Dental Health and Demineralization: A Systematic Review of the Literature

Children, Journal Year: 2022, Volume and Issue: 9(7), P. 1014 - 1014

Published: July 8, 2022

The oral microbiota plays a vital role in the human microbiome and health. Imbalances between microbes their hosts can lead to systemic disorders such as diabetes or cardiovascular disease. purpose of this review is investigate literature evidence dysbiosis on health discuss current knowledge emerging mechanisms governing polymicrobial synergy dysbiosis; both have enhanced our understanding pathogenic aided design innovative therapeutic approaches ORALBIOTICA for diseases demineralization. PubMed, Web Science, Google Scholar, Scopus, Cochrane Library, EMBEDDED, Dentistry & Oral Sciences Source via EBSCO, APA PsycINFO, PsyArticles, DRUGS@FDA were searched publications that matched topic from January 2017 22 April 2022, with an English language constraint using following Boolean keywords: ("microbio*" "demineralization*") AND ("oral microbiota" "demineralization"). Twenty-two studies included qualitative analysis. As seen by review, balance unstable influenced hygiene, presence orthodontic devices cavity poor eating habits modify its composition behavior positive negative ways, increasing development demineralization, caries processes, periodontal Under conditions dysbiosis, favored acidic environment, reproduction specific bacterial strains increases, favoring cariogenic ones Bifidobacterium dentium, longum,

Language: Английский

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The interplay between oral microbiota, gut microbiota and systematic diseases

Journal of Oral Microbiology, Journal Year: 2023, Volume and Issue: 15(1)

Published: May 15, 2023

Over the past two decades, importance of microbiota in health and disease has become evident. The human gut oral are largest second-largest microbiome body, respectively, they physically connected as cavity is beginning digestive system. Emerging exciting evidence shown complex important connections between microbiota. interplay microbiomes may contribute to pathological processes many diseases, including diabetes, rheumatoid arthritis, nonalcoholic fatty liver disease, inflammatory bowel pancreatic cancer, colorectal so on. In this review, we discuss possible routes factors affect microbiota, contribution systemic diseases. Although most studies association studies, recently, there have been increasing mechanistic investigations. This review aims enhance interest connection shows tangible impact on health.

Language: Английский

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Oral Microbiome: Getting to Know and Befriend Neighbors, a Biological Approach

Biomedicines, Journal Year: 2022, Volume and Issue: 10(3), P. 671 - 671

Published: March 14, 2022

The oral microbiome, forming a biofilm that covers the structures, contains high number of microorganisms. Biofilm formation starts from salivary pellicle allows bacterial adhesion-colonization-proliferation, co-aggregation and maturation in complex microbial community. There is constant bidirectional crosstalk between human host its microbiome. paper presents fundamentals regarding microbiome relationship to modulator factors, systemic health. modern studies microorganisms relationships with benefits are based on genomics, transcriptomics, proteomics metabolomics. Pharmaceuticals such as antimicrobials, prebiotics, probiotics, surface active or abrasive agents plant-derived ingredients may influence Many found associations dysbiosis disorders, including autoimmune diseases, cardiovascular, diabetes, cancers neurodegenerative disorders. We outline general individual factors influencing host-microbial balance possibility use analysis prevention, diagnosis treatment personalized medicine. Future therapies should take account restoration normal symbiotic relation

Language: Английский

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Oral Microbiota, Its Equilibrium and Implications in the Pathophysiology of Human Diseases: A Systematic Review

Biomedicines, Journal Year: 2022, Volume and Issue: 10(8), P. 1803 - 1803

Published: July 27, 2022

Imbalances of the oral microbiota and dysbiosis have traditionally been linked to occurrence teeth diseases. However, recent findings indicate that this exerts relevant influence in systemic health. Dysbiosis is implicated apparition progression cardiovascular, neurodegenerative other major human In fact, are second most diverse largely populated body its relationships with health, although widely explored, they still lack proper integration. The purpose systematic review thus examine implications oral, cardiovascular diseases offer integrative up-to-date interpretations. To achieve aim, we identified a total 121 studies curated PUBMED from time interval January 2003–April 2022, which after careful screening resulted 79 included. reviewed scientific literature provides plausible vias implication dysbiotic diseases, encourages further research continue elucidating highly poorly understood niche PROSPERO Registration Number: CRD42022299692. This follows PRISMA guidelines.

Language: Английский

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The role of the oral microbiome in obesity and metabolic disease: potential systemic implications and effects on taste perception

Nutrition Journal, Journal Year: 2023, Volume and Issue: 22(1)

Published: May 27, 2023

Abstract Obesity and its metabolic sequelae still comprise a challenge when it comes to understanding mechanisms, which drive these pandemic diseases. The human microbiome as potential key player has attracted the attention of broader research for past decade. Most focused on gut while oral received less attention. As second largest niche, is associated with multitude are potentially involved in complex etiology obesity These mechanisms include local effects bacteria taste perception subsequent food preference well systemic adipose tissue function, inflammation. This review summarizes growing body research, pointing towards more prominent role diseases than expected. Ultimately, our knowledge may support development new patient oriented therapeutic approaches inevitable relieve health burden reach long-term benefits patients´ lives.

Language: Английский

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Antimicrobial Mouthwashes: An Overview of Mechanisms—What Do We Still Need to Know?

International Dental Journal, Journal Year: 2023, Volume and Issue: 73, P. S64 - S68

Published: Oct. 17, 2023

This narrative literature review is the first in a 6-section supplement on role of mouthwashes oral care. introduction briefly summarises current knowledge antimicrobial mechanisms, relating to some most common over-the-counter mouthwash products available worldwide: chlorhexidine, hydrogen peroxide, cetylpyridinium chloride, povidone iodine, and essential oils. The aim this article describe how "kill" pathogenic microbes when used adjunctively thus provide basis for their widespread use manage key diseases, namely caries, gingivitis, periodontal disease. therefore sets scene subsequent, more detailed exploration regarding clinical effectiveness, impact microbiome, possible effects systemic health as well natural alternatives future directions. Other than effectiveness (for certain agents) mouthwashes, many topics there remains insufficient evidence systematic or formulation robust national guidelines. supplement, therefore, compiled by an international task team, aimed at general dental practitioners across globe, easy-to-read guide helping advise patients based best evidence.

Language: Английский

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A Holistic Approach for Ethics and Sustainability in the Food Chain: The Gateway to Oral and Systemic Health

Foods, Journal Year: 2024, Volume and Issue: 13(8), P. 1224 - 1224

Published: April 17, 2024

Food production is a complex matter, affecting people’s lives, organizations’ profits, and the well-being of whole planet, has multifaceted ethical considerations surrounding its production, distribution, consumption. This paper addresses pressing need to confront challenges within food system, encompassing issues such as environmental sustainability, security, individual choices for better oral systemic health all individuals around globe. From agricultural practices global trade waste, implications are addressed across various domains, highlighting interconnectedness decision-making in industry. Central themes explored include dimensions methods, impact on ethics, role making ethically informed choices. Additionally, this considers spiritual physical significance food, particularly through lens gateway holistic well-being. Recognizing complexity mouth ecosystem, calls serious interventions legislation economics promote protocols techniques sustainability reasons. It emphasizes importance safety management systems, regulatory frameworks, quality standards. Moreover, underlines comprehensive approach address dilemmas moral values inherent industry policies, adopting precautionary principle frameworks. article finally aims serve call action stakeholders healthcare sector, prioritize practices, transparency, rearrange economic parameters, work towards more sustainable equitable system inner outer human all.

Language: Английский

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Oral microbial dysbiosis in patients with oral cavity cancers

Clinical Oral Investigations, Journal Year: 2024, Volume and Issue: 28(7)

Published: June 17, 2024

Abstract Objectives The pathogenesis of oral cavity cancers is complex. We tested the hypothesis that microbiota dysbiosis associated with cancer. Materials and methods Patients primary cancer who met inclusion exclusion criteria were included in study. Matching healthy individuals recruited as controls. Data on socio-demographic behavioral factors, self-reported periodontal measures habits, current dental status collected using a structured questionnaire chartings. In addition to health measures, each participant received standard detailed clinical examination. DNA was extracted from saliva samples patients Next-generation sequencing performed by targeting V3-V4 gene regions 16 S rRNA subsequent bioinformatic analyses. Results had lower quality than Proteobacteria, Aggregatibacter, Haemophilus , Neisseria decreased, while Firmicutes, Bacteroidetes, Actinobacteria, Lactobacillus, Gemella Fusobacteria increased patients. At species level, C. durum, L. umeaens, N. subflava, A. massiliensis V. dispar significantly lower, G. haemolysans ( p < 0.05). Major periodontopathogens disease P. gingivalis F.nucleatum ) 6.5- 2.8-fold, respectively. Conclusion These data suggested worse conditions distinct microbiome composition affected personal daily habits may be pathogenicity interspecies interactions. Clinical relevance This paper demonstrates link between bacteria cancers, identifying mechanistic interactions microbiome.

Language: Английский

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Oral Microbiome: A Review of Its Impact on Oral and Systemic Health

Microorganisms, Journal Year: 2024, Volume and Issue: 12(9), P. 1797 - 1797

Published: Aug. 29, 2024

Purpose of review: This review investigates the oral microbiome’s composition, functions, influencing factors, connections to and systemic diseases, personalized care strategies. Recent findings: The microbiome is a complex ecosystem consisting bacteria, fungi, archaea, viruses that contribute health. Various such as diet, smoking, alcohol consumption, lifestyle choices, medical conditions, can affect balance lead dysbiosis, which result in health issues like dental caries, gingivitis, periodontitis, candidiasis, halitosis. Importantly, our explores novel associations between diseases including gastrointestinal, cardiovascular, endocrinal, neurological autoimmune cancer. We comprehensively efficacy interventions probiotics, xylitol, rinses, fluoride, essential oils, oil pulling, peptides promoting by modulating microbiome. Summary: emphasizes critical functions microbiota overall health, providing insights into effects microbial imbalances on various diseases. It underlines significant connection general Furthermore, it advantages probiotics other ingredients addressing common issues, offering comprehensive strategy for care.

Language: Английский

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Accelerated corrosion of 316L stainless steel in a simulated oral environment via extracellular electron transfer and acid metabolites of subgingival microbiota

Bioactive Materials, Journal Year: 2024, Volume and Issue: 35, P. 56 - 66

Published: Jan. 20, 2024

Language: Английский

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