Chemico-Biological Interactions,
Journal Year:
2024,
Volume and Issue:
395, P. 111009 - 111009
Published: April 17, 2024
The
escalating
prevalence
of
lung
diseases
underscores
the
need
for
innovative
therapies.
Dysbiosis
in
human
body
microbiome
has
emerged
as
a
significant
factor
these
diseases,
indicating
potential
role
synbiotics
restoring
microbial
equilibrium.
However,
effective
delivery
to
target
site
remains
challenging.
Here,
we
aim
explore
suitable
nanoparticles
encapsulating
tailored
applications
diseases.
Nanoencapsulation
prominent
strategy
address
challenges
this
context.
Through
comprehensive
review,
assess
facilitating
synbiotic
and
their
structural
adaptability
purpose.
Our
review
reveals
that
such
nanocellulose,
starch,
chitosan
exhibit
high
encapsulation.
These
offer
flexibility
structure
design
synthesis,
making
them
promising
candidates
addressing
Furthermore,
our
analysis
highlights
synbiotics,
when
compared
probiotics
alone,
demonstrate
superior
anti-inflammatory,
antioxidant,
antibacterial
anticancer
activities.
This
nanoparticle-encapsulated
targeted
therapeutic
approach
contributing
valuable
insights
into
nanomedicine
revolutionizing
treatment
strategies
respiratory
conditions,
ultimately
paving
way
future
advancements
field.
Discover Oncology,
Journal Year:
2023,
Volume and Issue:
14(1)
Published: May 6, 2023
Abstract
Hitherto,
the
recognition
of
microbiota
role
in
tumorigenesis
and
clinical
studies
mostly
focused
on
intestinal
flora.
In
contrast
to
gut
microbiome,
microorganisms
resident
tumor
tissue
are
close
contact
with
cancer
cells
therefore
have
potential
similar
or
even
different
functional
patterns
Some
investigations
shown
intratumoral
bacteria,
which
might
come
from
commensal
mucosal
areas
including
gastrointestinal
tract
oral
cavity,
nearby
normal
tissues.
The
existence,
origin,
interactions
bacteria
microenvironment
all
contribute
microorganism
heterogeneity.
Intratumoral
a
significant
formation.
They
can
at
genetic
level
by
secreting
poisons
that
directly
damage
DNA
also
intimately
related
immune
system
response
systemic
level.
an
impact
chemotherapy
immunotherapy
cancer.
Importantly,
various
properties
such
as
targeting
ease
modification
make
them
powerful
candidates
for
precision
therapy,
combining
microbial
therapies
other
is
expected
improve
effectiveness
treatment.
this
review,
we
mainly
described
heterogeneity
sources
overviewed
important
mechanisms
they
were
involved
progression,
summarized
their
value
oncology
therapy.
At
last,
highlight
problems
research
field,
look
forward
new
wave
using
applications
Life,
Journal Year:
2023,
Volume and Issue:
13(3), P. 812 - 812
Published: March 17, 2023
Bladder
cancer
is
the
10th
most
common
worldwide.
Approximately
75%
of
patients
with
bladder
will
present
non-muscle
invasive
disease.
Patients
are
usually
treated
transurethral
resection
tumor
(TURBT),
in
addition
to
adjuvant
intravesical
therapy
(chemotherapy
or
anti-cancer
immunotherapy
Bacillus
Calmette
Guerin-
BCG)
for
those
at
intermediate-risk
and
high-risk
recurrence
progression.
For
many
years,
urine
has
been
thought
be
“sterile”;
however,
advanced
microbiological
molecular
techniques,
including
16S
ribosomal
RNA
(16S
rRNA)
sequencing,
have
negated
that
previous
paradigm
confirmed
presence
a
urinary
microbiome.
The
microbiome
associated
several
urological
diseases,
interstitial
cystitis,
urgency
incontinence,
neurogenic
dysfunction,
others.
More
recently,
reports
emerging
about
role
urothelial
carcinogenesis,
gender
disparity
responses
treatments.
may
serve
as
biomarker
can
help
risk
stratification
well
prediction
response
therapies.
However,
literature
hampered
by
lack
unified
standardized
methodology
sample
collection,
type,
preservation,
processing,
bioinformatics
analysis.
Herein
we
describe
critique
on
association
between
highlight
some
future
directions.
Non-coding RNA Research,
Journal Year:
2023,
Volume and Issue:
9(1), P. 236 - 252
Published: Dec. 15, 2023
Gastrointestinal
cancers
are
a
huge
worldwide
health
concern,
which
includes
wide
variety
of
digestive
tract
cancers.
Circular
RNAs
(circRNAs),
kind
non-coding
RNA
(ncRNAs),
family
single-stranded,
covalently
closed
that
have
become
recognized
as
crucial
gene
expression
regulators,
having
an
impact
on
several
cellular
functions
in
cancer
biology.
The
gut
microbiome,
consists
different
bacteria,
actively
contributes
to
the
regulation
host
immunity,
inflammation,
and
metabolism.
CircRNAs
microbiome
interact
significantly
greatly
affect
growth
GI
cancer.
Several
studies
focus
complex
circRNAs
microbiota
cancers,
including
esophageal
cancer,
colorectal
gastric
hepatocellular
pancreatic
It
also
emphasizes
how
changed
circRNA
profiles
pathways
connected
malignancy
well
hallmarks
gastrointestinal
Furthermore,
been
recommended
biological
markers
for
therapeutic
targets
diagnostic
prognostic
purposes.
Targeting
treatment
is
being
continued
study.
Despite
significant
initiatives,
connection
between
emergence
remains
poorly
understood.
In
this
study,
we
will
go
over
most
recent
emphasize
key
roles
progression
options.
order
create
effective
therapies
plan
future
therapy,
it
important
comprehend
mechanisms
microbiota.
Cell Cycle,
Journal Year:
2024,
Volume and Issue:
23(3), P. 294 - 307
Published: Feb. 1, 2024
The
increase
of
the
Fusobacterium
nucleatum
level
has
been
previously
identified
in
various
cancers
including
gastric
cancer
(GC),
but
how
F.
exerts
its
carcinogenic
role
GC
remains
unclear.
Several
studies
revealed
that
contributes
to
progression
via
secretion
extracellular
vehicles
(EVs).
Hence,
it's
designed
reveal
influence
nucleatum-derived
EVs
(Fn-EVs)
progression.
tumor
and
adjacent
tissues
were
collected
from
30
patients,
abundance
was
found
be
highly
expressed
samples.
ultracentrifugation
employed
isolate
Escherischia
coli
(E.
coli),
which
labeled
Fn-EVs
E.
coli-EVs,
respectively.
After
treating
cells
with
cell
counting
kit
8,
colony
formation,
wound
healing
as
well
transwell
assay
performed,
effectively
enhanced
oxaliplatin
resistance,
facilitated
proliferation,
migration,
invasion,
stemness
while
coli-EVs
exert
no
significant
effect
on
cells.
Besides,
DNA
repair
also
by
Fn-EVs,
sphere-forming
detection
stemness-
repair-associated
proteins
western
blotting.
In
vivo
analyses
demonstrated
administration
not
only
promoted
growth
liver
metastasis
conferred
resistance
resistance.
This
study
first
contributive
development
provided
a
better
perspective
for
manipulating
patients
malignant
phenotypes.
Chemico-Biological Interactions,
Journal Year:
2024,
Volume and Issue:
395, P. 111009 - 111009
Published: April 17, 2024
The
escalating
prevalence
of
lung
diseases
underscores
the
need
for
innovative
therapies.
Dysbiosis
in
human
body
microbiome
has
emerged
as
a
significant
factor
these
diseases,
indicating
potential
role
synbiotics
restoring
microbial
equilibrium.
However,
effective
delivery
to
target
site
remains
challenging.
Here,
we
aim
explore
suitable
nanoparticles
encapsulating
tailored
applications
diseases.
Nanoencapsulation
prominent
strategy
address
challenges
this
context.
Through
comprehensive
review,
assess
facilitating
synbiotic
and
their
structural
adaptability
purpose.
Our
review
reveals
that
such
nanocellulose,
starch,
chitosan
exhibit
high
encapsulation.
These
offer
flexibility
structure
design
synthesis,
making
them
promising
candidates
addressing
Furthermore,
our
analysis
highlights
synbiotics,
when
compared
probiotics
alone,
demonstrate
superior
anti-inflammatory,
antioxidant,
antibacterial
anticancer
activities.
This
nanoparticle-encapsulated
targeted
therapeutic
approach
contributing
valuable
insights
into
nanomedicine
revolutionizing
treatment
strategies
respiratory
conditions,
ultimately
paving
way
future
advancements
field.
