Intratumoral microbiome of adenoid cystic carcinomas and comparison with other head and neck cancers DOI Creative Commons
Tatiana V. Karpinets, Yoshitsugu Mitani, Chia‐Chi Chang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: July 15, 2024

Abstract Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution microenvironment in ACC remains limited. We investigated intratumoral microbiomes 50 tumor tissues 33 adjacent normal using 16S rRNA gene sequencing. This allowed us to characterize bacterial communities within explore potential associations between community structure, patient characteristics, molecular features obtained through RNA The composition was significantly different from that salivary tissue, exhibited diverse levels species richness. identified two main microbial subtypes ACC: oral-like gut-like. Oral-like microbiomes, characterized by increased diversity abundance Neisseria, Leptotrichia, Actinomyces, Streptococcus, Rothia, Veillonella (commonly found healthy oral cavities), were associated with less ACC-II subtype improved outcomes. Notably, we same genera cancer squamous cell carcinomas. In both cancers, they part shared more microbiome, phenotype, better survival reveal as pancancer biomarkers for favorable other cancers. Conversely, gut-like which feature low colonization gut mucus layer-degrading species, such Bacteroides, Akkermansia, Blautia, Bifidobacterium, Enterococcus , poorer Elevated Bacteroides thetaiotaomicron independently worse positively correlated biosynthesis glycan-based membrane components.

Language: Английский

Intratumoral microbiota: implications for cancer onset, progression, and therapy DOI Creative Commons
Jinmei Wu, Pengfei Zhang,

Wuxuan Mei

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Significant advancements have been made in comprehending the interactions between microbiome and cancer. However, prevailing research predominantly directs its focus toward gut microbiome, affording limited consideration to of intratumoral microbiota tumors. Within tumor microenvironment (TME), associated products wield regulatory influence, directing modulation cancer cell properties impacting immune system functionality. grasp a more profound insight into cancer, further underlying mechanisms is necessary. In this review, we delve intricate associations with specific on elucidating significant contribution onset advancement Notably, provide detailed exploration therapeutic advances facilitated by microbiota, offering insights recent developments burgeoning field.

Language: Английский

Citations

14
Akkermansia muciniphila: A potential target and pending issues for oncotherapy DOI Creative Commons
Xu Zhao, Juanjuan Zhao, Dongmei Li

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 196, P. 106916 - 106916

Published: Sept. 9, 2023

In the wake of development metagenomic, metabolomic, and metatranscriptomic approaches, intricate interactions between host various microbes are now being progressively understood. Numerous studies have demonstrated evident changes in gut microbiota during process a variety diseases, such as diabetes, obesity, aging, cancers. Notably, is viewed potential source novel therapeutics. Currently, Next-generation probiotics (NGPs) gaining popularity therapeutic agents that alter affect cancer development. Akkermansia muciniphila (A. muciniphila), representative commensal bacterium, has received substantial attention over past decade promising NGP. The components metabolites A. can directly or indirectly tumorigenesis, particular through its effects on antitumor immunosurveillance, including stimulation pattern recognition receptors (PRRs), which also leads to better outcomes situations, prevention curation this article, we systematically summarize role tumorigenesis (involving gastrointestinal non-gastrointestinal cancers) tumor therapy. particular, carefully discuss some critical scientific issues need be solved for future using beneficial bacterium treatment, might provide bright clues assistance application drugs targeting clinical oncotherapy.

Language: Английский

Citations

22
Aggregatibacter actinomycetemcomitans: From the Oral Cavity to the Heart Valves DOI Creative Commons
Jasminka Talapko, Martina Juzbašić,

Tomislav Meštrović

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(7), P. 1451 - 1451

Published: July 17, 2024

Aggregatibacter actinomycetemcomitans (A. actinomycetecomitans) is a Gram-negative bacterial species that an essential component of the oral microbiota. Due to its aggregative properties, it plays role in pathogenesis human diseases. The presence surface proteins Fim, Briae, and microvesicles enables bacterium adhere epithelial tooth’s surface. leukotoxin A (LtxA), which important pathogenicity bacterium, has been associated with both periodontitis etiology rheumatoid arthritis (RA). A. actinomycetecomitans also several other systemic diseases complications, such as endocarditis different abscesses. In addition A, possesses virulence factors, including bacteriocins, chemotaxis inhibitory cytotoxic Fc-binding proteins, immunosuppressive lipopolysaccharide collagenase, fibroblast antibiotic resistance determinants, adhesins, invasive factors inhibit function polymorphonuclear leukocytes. ability induce macrophages secrete interleukins IL-1, IL-1β, tumor necrosis factor (TNF) considerable importance. primary etiologic periodontal disease biofilm colonized by anaerobic bacteria. Among these, occupies place facultative bacterium. addition, many contribute potential cause cancer. This article provides overview association various diseases, oncogenic potential, treatment options for infections caused actinomycetecomitans.

Language: Английский

Citations

6
Intratumoral microorganisms in tumors of the digestive system DOI Creative Commons

Mengjuan Xuan,

Xinyu Gu,

Yingru Liu

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 25, 2024

Abstract Tumors of the digestive system pose a significant threat to human health and longevity. These tumors are associated with high morbidity mortality rates, leading heavy economic burden on healthcare systems. Several intratumoral microorganisms present in tumors, their sources abundance display heterogeneity depending specific tumor subtype. microbes have complex precise function neoplasm. They can facilitate growth through various mechanisms, such as inducing DNA damage, influencing antitumor immune response, promoting degradation chemotherapy drugs. Therefore, these be targeted inhibit progression for improving overall patient prognosis. This review focuses current research progress how they influence initiation, progression, prognosis tumors. Furthermore, primary constituents microbiome delineated. Finally, we summarize application potential diagnosis, treatment, prediction

Language: Английский

Citations

2
Microbiome—Stealth Regulator of Breast Homeostasis and Cancer Metastasis DOI Open Access
Saori Furuta

Cancers, Journal Year: 2024, Volume and Issue: 16(17), P. 3040 - 3040

Published: Aug. 31, 2024

Cumulative evidence attests to the essential roles of commensal microbes in physiology hosts. Although microbiome has been a major research subject since time Luis Pasteur and William Russell over 140 years ago, recent findings that certain intracellular bacteria contribute pathophysiology healthy vs. diseased tissues have brought field new era investigation. Particularly, breast cancer research, breast-tumor-resident are now deemed be players tumor initiation progression. This is resurrection Russel's bacterial cause theory, which was fact abandoned 100 ago. review will introduce some exemplify carcinogenesis metastasis provide mechanistic explanations for these phenomena. Such information would able justify utility as biomarkers disease progression therapeutic targets.

Language: Английский

Citations

2
Human anaerobic microbiome: a promising and innovative tool in cancer prevention and treatment by targeting pyruvate metabolism DOI
Hari Om, Umesh Chand, Pramod Kumar Kushawaha

et al.

Cancer Immunology Immunotherapy, Journal Year: 2023, Volume and Issue: 72(12), P. 3919 - 3930

Published: Oct. 26, 2023

Language: Английский

Citations

4
The intratumoral microbiota: a new horizon in cancer immunology DOI Creative Commons
Wei Liu, Yuming Li, Ping Wu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: July 29, 2024

Over the past decade, advancements in high-throughput sequencing technologies have led to a qualitative leap our understanding of role microbiota human diseases, particularly oncology. Despite low biomass intratumoral microbiota, it remains crucial component tumor immune microenvironment, displaying significant heterogeneity across different tissues and individual patients. Although immunotherapy has emerged major strategy for treating tumors, patient responses these treatments vary widely. Increasing evidence suggests that interactions between system can modulate host responses, thereby influencing effectiveness immunotherapy. Therefore, is critical gain deep how shapes regulates microenvironment. Here, we summarize latest on cancer immunity, exploring potential mechanisms through which functions are influenced by within outside gut barrier. We also discuss impact response its clinical applications, highlighting future research directions challenges this field. anticipate valuable insights into immunity provided review will foster development microbiota-based therapies.

Language: Английский

Citations

1
Could intratumoural microbiota be key to unlocking treatment responses in hepatocellular carcinoma? DOI Creative Commons

Kin Lam Yu,

Sj Shen

European Journal of Cancer, Journal Year: 2024, Volume and Issue: 216, P. 115195 - 115195

Published: Dec. 21, 2024

Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality worldwide. Current treatments include surgery and immunotherapy with variable response. Despite aggressive treatment, disease progression remains biggest contributor to mortality. Thus, there an urgent unmet need improve current through a better understanding HCC tumourigenesis. The gut microbiota has been intensively examined in context HCC, evidence showing modulation potential modulate tumourigenesis prognosis. In addition, recent literature suggests presence intratumoural that may exert significant impacts on development solid tumours including HCC. By drawing parallels between hepatic/tumoural microbiota, we explore present review how hepatic established, its impact tumourigenesis, be key improving particular, highlight bacteria have discovered tumours, they affect tumour immune microenvironment We then therapies target microbiota. With deeper different involved can targeted, hope spark future research validating as avenue for treatment responses

Language: Английский

Citations

1
Intratumoral Microbiome of Adenoid Cystic Carcinomas and Comparison with other Head and Neck Cancers DOI Open Access
Tatiana V. Karpinets, Yoshitsugu Mitani, Chia‐Chi Chang

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 30, 2024

ABSTRACT Background Adenoid cystic carcinoma (ACC) is a rare, slow growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution microenvironment in ACC remains limited. Methods We investigated intratumoral microbiome 50 tumors 33 adjacent normal tissues using 16S rRNA gene sequencing. This allowed us to characterize bacterial communities within explore potential associations between community structure, patient’s characteristics, tumor molecular features obtained through RNA Results Bacterial composition displayed significant differences compared salivary tissue exhibited diverse levels species richness. identified two main microbial subtypes ACC: oral-like gut-like. Oral-like microbiomes, characterized by higher diversity abundance genera like Neisseria, Leptotrichia, Actinomyces, Streptococcus, Rothia , Veillonella (commonly found healthy oral cavities), were associated with less ACC-II subtype improved patient outcomes. Notably, we same cancer squamous cell carcinomas. In both cancers, they part shared more microbiome, phenotype, better survival. Conversely, gut-like microbiomes ACC, featuring low colonization gut mucus layer-degrading Bacteroides, Akkermansia, Blautia, Bifidobacterium Enterococcus poorer Elevated Bacteroides thetaiotaomicron independently significantly worse survival, regardless other factors. Furthermore, this association positively correlated biosynthesis glycan-based membrane components. Conclusions Our study uncovers specific as pan-cancer biomarkers for favorable cancers. These findings highlight pivotal role influencing prognosis disease biology.

Language: Английский

Citations

0
Intratumoral Microbiome of Adenoid Cystic Carcinomas and Comparison with Other Head and Neck Cancers DOI Creative Commons
Tatiana V. Karpinets, Yoshitsugu Mitani, Chia‐Chi Chang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 16, 2024

Abstract Background: Adenoid cystic carcinoma (ACC) is a rare, usually slow-growing yet aggressive head and neck malignancy. Despite its clinical significance, our understanding of the cellular evolution microenvironment in ACC remains limited. Methods: We investigated intratumoral microbiomes 50 tumor tissues 33 adjacent normal using 16S rRNA gene sequencing. This allowed us to characterize bacterial communities within explore potential associations between community structure, patient characteristics, molecular features obtained through RNA Results: The composition was significantly different from that salivary tissue, exhibited diverse levels species richness. identified two main microbial subtypes ACC: oral-like gut-like. Oral-like microbiomes, characterized by increased diversity abundance Neisseria, Leptotrichia, Actinomyces, Streptococcus, Rothia, Veillonella (commonly found healthy oral cavities), were associated with less ACC-II subtype improved outcomes. Notably, we same genera cancer squamous cell carcinomas. In both cancers, they part shared more microbiome, phenotype, better survival. Conversely, gut-like which feature low colonization gut mucus layer-degrading species, such as Bacteroides, Akkermansia, Blautia, Bifidobacterium, Enterococcus , poorer Elevated Bacteroides thetaiotaomicron independently worse survival, regardless other factors. Furthermore, these positively correlated biosynthesis glycan-based membrane components. Conclusions: Our study specific pancancer biomarkers for favorable cancers. These findings highlight pivotal role microbiome influencing prognosis disease biology.

Language: Английский

Citations

0