The value of intratumoral microbiota in the diagnosis and prognosis of tumors

Cell Biochemistry and Function, Journal Year: 2024, Volume and Issue: 42(3)

Published: April 1, 2024

Abstract Intratumoral microbiota (ITM) are microorganisms present in tumor cells. ITM participate development by affecting cells directly and the microenvironment (TME), indirectly. Alterations instigate changes DNA, activate oncogenic pathways, induce inflammatory responses, disrupt normal immune activity, facilitate secretion of effectors leading to progression, metastasis, or diminished therapeutic effects. varies significantly different types cancer disease states. The presence certain serves as a predictor various Thus, predicts tumorigenesis, grade, treatment efficacy, prognosis, making it potential biomarker. study aimed determine mechanisms which affects development, especially through TME; highlight significant enhancing diagnosis prognosis; outline future directions for research, with focus on innovative markers.

Language: Английский

---

Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 917 - 917

Published: July 27, 2024

Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores interplay between intratumoral microbiota, tumor metabolism, major types GI (including esophageal, gastric, liver, pancreatic, colorectal cancers), summarizing recent studies elucidating clinical implications future directions. Recent research revealed altered microbial signatures within tumors, impacting progression, immune responses, outcomes. Dysbiosis-induced alterations in including glycolysis, fatty acid amino play critical roles cancer progression therapeutic resistance. The integration molecular mechanisms potential biomarkers into this further enhances prognostic significance microbiota composition opportunities targeting microbiota-mediated metabolism. Despite advancements, challenges remain dynamic interactions microenvironment (TME). Future directions, advanced omics technologies prospective studies, offer promising avenues precision oncology personalized interventions cancer. Overall, integrating microbiota-based approaches management holds promise improving patient outcomes survival.

Language: Английский

---

Could intratumoural microbiota be key to unlocking treatment responses in hepatocellular carcinoma?

European Journal of Cancer, Journal Year: 2024, Volume and Issue: 216, P. 115195 - 115195

Published: Dec. 21, 2024

Hepatocellular carcinoma (HCC) is the third cause of cancer-related mortality worldwide. Current treatments include surgery and immunotherapy with variable response. Despite aggressive treatment, disease progression remains biggest contributor to mortality. Thus, there an urgent unmet need improve current through a better understanding HCC tumourigenesis. The gut microbiota has been intensively examined in context HCC, evidence showing modulation potential modulate tumourigenesis prognosis. In addition, recent literature suggests presence intratumoural that may exert significant impacts on development solid tumours including HCC. By drawing parallels between hepatic/tumoural microbiota, we explore present review how hepatic established, its impact tumourigenesis, be key improving particular, highlight bacteria have discovered tumours, they affect tumour immune microenvironment We then therapies target microbiota. With deeper different involved can targeted, hope spark future research validating as avenue for treatment responses

Language: Английский

---

Mechanism-guided fine-tuned microbiome potentiates anti-tumor immunity in HCC

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 19, 2023

Microbiome, including bacteria, fungi, and viruses, plays a crucial role in shaping distal proximal anti-tumor immunity. Mounting evidence showed that commensal microbiome critically modulates immunophenotyping of hepatocellular carcinoma (HCC), leading cause cancer-related death. However, their surveillance HCC is still poorly understood. Herein, we spotlighted growing interests how the influences progression immunotherapeutic responses via changing local tumor microenvironment (TME) upon translocating to sites through different “cell-type niches”. Moreover, summarized not only associations but also deep insight into mechanisms extrinsic microbiomes interplay with hosts shape immune regulate TME responses. Collectively, provided rationale for mechanism-guided fine-tuned be neoadjuvant immunotherapy near future.

Language: Английский

---

Etiology-Dependent Microbiome Differences in Hepatocellular Carcinoma Development

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13510 - 13510

Published: Dec. 17, 2024

Chronic liver disease is characterised by persistent inflammation, tissue damage, and regeneration, which leads to steatosis, fibrosis, and, lastly, cirrhosis hepatocellular carcinoma (HCC). HCC, the most prevalent form of primary cancer, one leading causes cancer-related mortality worldwide. The gut microbiota plays a fundamental role in human physiology, disturbances its critical balance are widely recognised as contributors various pathological conditions, including chronic diseases, both infectious non-infectious nature. Growing interest research has recently shifted focus towards study intratumoural microbiota, referred “oncobiome”, can significantly impact development progression HCC. In this review, we discuss existing provide an overview influence on viral hepatitis, particularly shaping caused hepatitis B C viruses. We also explore microbial dysbiosis contribution silent dangerous non-alcoholic fatty disease. Additionally, address alcohol interaction with tracing pathway from inflammation cancer. review emphasises common etiologies carcinoma.

Language: Английский

---