The non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio as a predictive indicator of CKD risk in NAFLD patients: NHANES 2017–2020 DOI Creative Commons

Yong-Qiang Fan,

Hao Wang, Peipei Wang

et al.

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: Dec. 24, 2024

Background Non-alcoholic fatty liver disease (NAFLD) and chronic kidney (CKD) are both closely related to dyslipidemia. However, the relationship between dyslipidemia in patients with NAFLD CKD is not yet clear. The non-high-density lipoprotein cholesterol high-density ratio (NHHR) an innovative comprehensive lipid index. purpose of this study was investigate correlation NHHR risk or without fibrosis. Methods This used data from National Health Nutrition Examination Survey (NHANES) 2017 2020 for analysis, including a total 4,041 subjects diagnosed NAFLD. Among subjects, 3,315 individuals fibrosis 726 Weighted multivariate linear regression, weighted logistic restricted cubic spline (RCS) curves, subgroup analysis were evaluate Results Our findings indicate that fibrosis, highest tertile NHHR, as compared lowest tertile, inversely glomerular filtration rate (eGFR) ( β : −2.14, 95% CI: −3.97, −0.32, p < 0.05) positively (OR: 1.67, 1.12, 2.49, 0.05). No significant associations observed eGFR, urinary albumin creatinine (ACR) RCS revealed ACR, while U-shaped Conclusion In non-fibrotic NAFLD, significantly elevated associated increased shows CKD. fibrotic LD, underscore practical utility biomarker early stratification

Language: Английский

Revealing the anti-senescence effects and related mechanisms of flavonoid extracts from the buds of Wikstroemia chamaedaphne Meisn on D-galactose-induced PC12 cells based on network pharmacology and transcriptomics DOI Creative Commons
Xiu-Ying Zhao,

Wen-Qian Liu,

Liwei Zhang

et al.

Future Journal of Pharmaceutical Sciences, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 10, 2025

Abstract Background Natural products are an important source of drugs or lead compounds for the treatment senescence. The buds Wikstroemia chamaedaphne Meisn a traditional Chinese medicine to cure edema, schizophrenia and epilepsy. A flavonoid extract W. (FEW) was prepared from methanolic by our group previously, which including eight flavonoids with content (55.19 ± 0.32) %. In this study, anti-senescence effects related mechanisms FEW on D-galactose-induced PC12 cells were investigated first time. Results High doses D-galactose could induce cell senescence, whereas delay senescence decreasing SA-β-gal positivity, increasing SOD activity, reducing MDA levels, improving morphology, inhibiting cycle arrest down-regulating expression senescence-related proteins P16, P21 P53. Subsequently, potential underlying elucidated through integration network pharmacology transcriptomics. main signaling pathways involved found be cancer pathway, FOXO PI3k–Akt AGE–RAGE protein digestion uptake, etc. may pathway as revealed western blot experiments. Conclusion Our study that has effects. This suggest acts agent age-related neurological diseases.

Language: Английский

Citations

0
Elevated urinary phytoestrogens are associated with delayed biological aging: a cross-sectional analysis of NHANES data DOI Creative Commons
Jing Wang, Qi Cao, Minjie Gao

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 12, 2025

Dietary phytoestrogens have been suggested to provide protection against numerous age-related diseases. However, their effects on biological aging remain unclear. In this study, we cross-sectionally investigated the relationship between urinary phytoestrogen levels and indicators of using data from 7,981 adults who participated in National Health Nutrition Examination Survey 1999–2010. Urinary concentrations six phytoestrogens, including four isoflavones two enterolignans, were measured high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS) or HPLC-atmospheric pressure photoionization-tandem MS, standardized creatinine. Three age (BA), namely Klemera-Doubal method (KDM-BA), phenotypic (PA), homeostatic dysregulation (HD), derived 12 clinical biomarkers, advanced-BAs calculated quantify differences individuals' BAs chronological age, individuals with all positive defined as accelerated-aging. Weighted linear regression analysis showed that after adjusting for demographic lifestyle factors history chronic diseases, elevated total enterolignans significantly associated less advanced-KDM, advanced-PA, advanced-HD, whereas was advanced-KDM advanced-PA but not advanced-HD. logistic higher (highest Q4 vs. lowest Q1: OR = 0.60, 95%CI: 0.44, 0.80; P-trend 0.002) (Q4 0.59, 0.45, 0.76; < 0.001) lower odds accelerated-aging, significant 0.78, 1.08; 0.05). Subgroup analyses negative associations attenuated non-overweight/obese participants current cigarette smokers. conclusion, are related markers slower aging, suggesting an anti-aging effect dietary consumption, which warrants further investigations longitudinal interventional settings.

Language: Английский

Citations

0
Calycosin treats acute myocardial infarction via NLRP3 inflammasome: Bioinformatics, network pharmacology and experimental validation DOI
Huajing Yuan,

Quancheng Han,

Hui Yu

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177621 - 177621

Published: April 1, 2025

Language: Английский

Citations

0
Association between methyl donor nutrients’ dietary intake with phenotypic aging among US adults: a cross-sectional study from NHANES 2005–2018 DOI Creative Commons
Yong Li, Da Peng,

Zhiyong Yu

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 12, 2025

This study investigates the association between dietary methyl donor nutrients intake and phenotypic aging. cross-sectional comprised 27,211 adult participants from NHANES 2005-2018. The methyl-donor nutritional quality index (MNQI) was calculated by assessing of seven nutrients: protein, folate, choline, riboflavin, vitamin B6, B12, zinc. Phenotypic age acceleration (PhenoAge.Accel) using biochemical markers to assess biological Weighted generalized linear regression models were utilized associations MNQI PhenoAge.Accel, impact different demographic health characteristics evaluated through interaction effect tests. After adjusting for various potential confounding factors, a significant negative found PhenoAge.Accel (β = - 0.66; 95% CI 0.91, 0.40; P < 0.0001), indicating that an increase in is associated with slowdown PhenoAge.Accel. Furthermore, subgroup analysis indicated stronger negatively males 0.94; 1.36, 0.52) interactions (Pinteraction 0.02). In populations, PhenoAge Accel, suggesting choosing high-quality foods can help develop effective strategies enhance healthy longevity.

Language: Английский

Citations

0
Delaying liver aging: Analysis of structural and functional alterations DOI
Yuqin Yao,

Qiong-Yue Cao,

Zheng Li

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(15)

Published: April 17, 2025

This article is based on a recent bibliometric analysis of research progress liver aging. The notable for its extraordinary ability to rejuvenate, thereby safeguarding and maintaining the organism's integrity. With advancing age, there noteworthy reduction in both liver's size blood circulation. Furthermore, wide range physiological alterations driven by aging may foster development illnesses. Previous studies indicate that linked impaired lipid metabolism abnormal gene expression associated with chronic inflammation. Factors such as mitochondrial dysfunction telomere shortening accumulate, which result increased hepatic steatosis, impacts regeneration, metabolism, other functions. Knowing structural functional changes could help elderly adults delay Increasing public awareness anti-aging interventions essential. Besides use dietary supplements, lifestyle, including habits physical exercise routines, are most efficacious means decelerate process liver. highlights advances mechanism summarizes promising intervention options preventing related diseases.

Language: Английский

Citations

0
The association between dietary quality and biological aging: two-mediation analysis DOI Creative Commons
Lang Zeng, Wu Yiting, Fengping Zhang

et al.

Aging Clinical and Experimental Research, Journal Year: 2025, Volume and Issue: 37(1)

Published: April 21, 2025

Language: Английский

Citations

0
Oxidative stress and inflammation mediate the association between Life's Crucial 9 and biological ageing: A secondary analysis of two observational studies DOI Creative Commons
Haoran Wang, Jingwen Zhang, Jing Ning

et al.

The journal of nutrition health & aging, Journal Year: 2025, Volume and Issue: 29(7), P. 100575 - 100575

Published: May 6, 2025

Language: Английский

Citations

0
The association between frailty index and abdominal aortic calcification in the middle-aged and older US adults: NHANES 2013–2014 DOI Creative Commons
Zhengjun Zhang,

Peng Wu,

Shaobin Yang

et al.

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: May 7, 2025

Background Abdominal aortic calcification (AAC) is one of the earliest observed forms atherosclerotic and crucial for early cardiovascular risk prediction. Frailty, a global clinical public health challenge, associated with increased risks mortality, functional decline, loss independence. However, relationship between Frailty Index (FI) AAC among middle-aged older adults has yet to be explored. Methods This study analyzed data from 2013 2014 National Health Nutrition Examination Survey (NHANES) cohort, focusing on individuals aged ≥ 40 years. The FI was calculated using 49-item model assess frailty status participants were stratified into three groups: non-frail (FI ≤ 0.15), pre-frail (0.15 &lt; 0.25), frail &gt; 0.25). measured by dual-energy X-ray absorptiometry quantified Kauppila scores. Severe defined as an score 6. investigated multivariable logistic regression, sensitivity analyses, smoothing curve fitting. Subgroup analyses interaction tests conducted stability this association across different populations. Results A total 2,572 enrolled in study. Following adjustment potential confounders, exhibited statistically significant positive both (β = 2.64, 95%CI 1.20–4.08) (OR 6.36, 1.48–27.41). Similar trends ( P trend 0.05) when categorical variable. Smooth fitting subgroup analysis used investigate baseline Z-score AAC. Interestingly, we found that linearly related occurrence severe AAC, while it nonlinearly score. FI-Z positively likelihood before breakpoint K 0.78), but not after breakpoint. stable subgroups (all 0.05). Conclusion Our indicated correlation may serve biomarker subclinical atherosclerosis detection US adults.

Language: Английский

Citations

0
The association of smoking on the increased risk of osteoporotic fracture: Results from a cross-sectional study and two-sample Mendelian randomization DOI Creative Commons
Min Fang, Zhi Xia,

Xueyao Rong

et al.

Tobacco Induced Diseases, Journal Year: 2024, Volume and Issue: 22(June), P. 1 - 11

Published: June 27, 2024

1. Marti-Aguado D, Clemente-Sanchez A, Bataller R. Cigarette smoking and liver diseases. J Hepatol. 2022;77(1):191-205. doi:10.1016/j.jhep.2022.01.016 CrossRef Google Scholar

Language: Английский

Citations

3
Correlation of dietary flavonoid intake with chronic bronchitis, emphysema, and asthma in U.S. adults: A large, national, cross-sectional study DOI Creative Commons
Mengshi Sun, Qin Ding

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(10), P. e0309310 - e0309310

Published: Oct. 21, 2024

Objective To explore the relationship between dietary flavonoids and bronchitis, emphysema asthma. Method A total of 11743 United States adults were extracted from National Health Nutrition Examination Survey (NHANES) in 2007–2008, 2009–2010 2017–2018. Of these, 47.7% male 52.3% female. Dietary flavonoid intake assessed using FDNNS 24-hour recall data. Inclusion demographics (gender, age, education, family income), behavioral factors (BMI, smoking, drinking status, diet), chronic disease information (diabetes, hypertension) as covariates to eliminate confounding. Stepwise logistic regression was used analyze association risk respiratory disease. Weighted quantile sum (WQS) 29 Restricted cubic spline dose-response Results results showed that higher men associated with a lower CB asthma (OR CB: 0.55(0.31–0.97); OR asthma: 0.72(0.52–0.99)), WQS mixed health effect for tract response fractions 0.97(0.94–0.99); emphysema: 0.95(0.90–0.99)). Glycitein had highest contribution 26.2% emphysema; Eriodictyol 32.13% asthma, respectively. The RCS health. maximum dose ingesting gain benefits is 1500 mg/d. Conclusion Higher adult U.S. men. Also components have an overall on may potential effects system. mg/day be Tolerable Upper Intake Level adults.

Language: Английский

Citations

2