Light-eye-body axis: exploring the network from retinal illumination to systemic regulation DOI Creative Commons
Yi Zeng, Rong Rong,

Mengling You

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(4), P. 1496 - 1523

Published: Dec. 31, 2024

The human body is an intricate system, where diverse and complex signaling among different organs sustains physiological activities. eye, as a primary organ for information acquisition, not only plays crucial role in visual perception but also, increasing evidence suggests, exerts broad influence on the entire through circuits upon receiving light signals which called non-image-forming vision. However, extent mechanisms of light's impact eyes remain insufficiently explored. There also dearth comprehensive reviews elucidating interplay between light, systemic connections to body. Herein, we propose concept light-eye-body axis systematically encapsulate extensive effects received by retina We reviewed visual-neural structure basis axis, summarized mechanism regulate whole current research status challenges within pathological processes involved axis. Future should aim expand explore its deeper mechanisms. Understanding investigating will contribute improving lighting conditions optimize health guide establishment phototherapy standards clinical practice.

Language: Английский

Liver fibrosis: More than meets the eye DOI Creative Commons
Amedeo Lonardo

Annals of Hepatology, Journal Year: 2024, Volume and Issue: 29(4), P. 101479 - 101479

Published: Feb. 10, 2024

Language: Английский

Citations

5
Exploring the hepatic-ophthalmic axis through immune modulation and cellular dynamics in diabetic retinopathy and non-alcoholic fatty liver disease DOI Creative Commons
Shuyan Zhang, Jiajun Wu, Leilei Wang

et al.

Human Genomics, Journal Year: 2025, Volume and Issue: 19(1)

Published: Feb. 26, 2025

Dysfunctions within the liver system are intricately linked to progression of diabetic retinopathy (DR) and non-alcoholic fatty disease (NAFLD). This study leverages systematic analysis elucidate complex cross-talk communication pathways among diverse cell populations implicated in pathogenesis DR NAFLD. Single-cell RNA sequencing data for proliferative (PDR) NAFLD were retrieved from Gene Expression Omnibus (GEO) database. Differential gene expression was conducted followed by pseudo-time delineate dynamic changes core cells differentially expressed genes (DEGs). CellChat employed predict intercellular signaling pathways. Additionally, set enrichment variation analyses (GSEA GSVA) performed uncover key functional enrichments. Our comparative two datasets focused on T cells, macrophages endothelial revealing SYNE2 as a notable DEG. Notably, common including PYHIN1, SLC38A1, ETS1 (T cells), PPFIBP1, LIFR, HSPG2 (endothelial MSR1 (macrophages), emerged top 50 DEGs across these types. The CD45 pathway pivotal macrophages, exerting profound effects other both PDR Moreover, GSEA GSVA underscored their involvement cellular communication, immune modulation, energy metabolism, mitotic processes. comprehensive investigation advances our understanding intricate biological processes underpinning research underscores imperative exploring immune-related interactions, shedding light novel therapeutic avenues contexts.

Language: Английский

Citations

0
Metabolic Dysfunction-Associated Steatotic Liver Disease Induced by Microplastics: An Endpoint in the Liver–Eye Axis DOI Open Access
Ivan Šoša,

Loredana Labinac,

Manuela Perković

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(7), P. 2837 - 2837

Published: March 21, 2025

There is a significant, rather than just anecdotal, connection between the liver and eyes. This evident in noticeable cases such as jaundice, where sclera has yellow tint. But this can be seen through even more subtle indicators, molecules known hepatokines. relationship not merely anecdotal; some studies, it referred to “liver–eye axis”. Ubiquitous environmental contaminants, microplastics (MPs), enter bloodstream human body conjunctival sac, nasolacrimal duct, upper respiratory tract mucosa. Once absorbed, these substances accumulate various organs cause harm. Toxic from surface of eye lead local oxidative damage by inducing apoptosis corneal cells, irregularly shaped microparticles exacerbate effect. Even other toxicants ocular may absorbed into distributed throughout body. Environmental toxicology presents challenge because many pollutants same route that used certain medications. Previous research indicated accumulation MPs play major role development chronic disease humans. It crucial investigate whether buildup potential fibrosis, or simply consequence conditions cirrhosis portal hypertension.

Language: Английский

Citations

0
Prunella vulgaris Polyphenols Alleviate Liver Injury-Uveitis Comorbidity by Regulating Acylcarnitine via the S100A9-PP2A-AMPK Pathway DOI
Jingchen Xie,

Suhui Xiong,

Jiahui Yu

et al.

Phytomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 156675 - 156675

Published: March 1, 2025

Language: Английский

Citations

0
Thinking outside the box: unconventional artificial intelligence algorithms in the detection and management of liver cirrhosis DOI Creative Commons
Ahmed Hashim, Bernardo Stefanini, Fabio Piscaglia

et al.

Expert Review of Gastroenterology & Hepatology, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Keywords: CirrhosisArtificial IntelligenceECGslit-lampeye fundushepatic encephalopathyLarge language modelCNN

Language: Английский

Citations

0
The potential role of adipokines and hepatokines in age-related ocular diseases DOI Creative Commons
Stavroula Almpanidou, Ilias D. Vachliotis, A. Goulas

et al.

Metabolism Open, Journal Year: 2025, Volume and Issue: unknown, P. 100365 - 100365

Published: April 1, 2025

Language: Английский

Citations

0
Detection of Retinal Microvascular Changes with Optical Coherence Tomography Angiography in Patients with Acute Leukemia Without Retinopathy DOI Creative Commons
Miao Zhou,

Kinji Hashimoto,

Duo Wei

et al.

Ophthalmology and Therapy, Journal Year: 2024, Volume and Issue: 13(5), P. 1145 - 1157

Published: Feb. 28, 2024

Acute leukemia often affects microcirculation perfusion. This study aimed to investigate retinal microvascular changes in patients with acute without retinopathy during clinical remission using optical coherence tomography angiography (OCTA) and determine the correlation of these systemic laboratory values. Thirty-eight from no (NLR group) 36 age-matched healthy individuals (control were included this cross-sectional study. OCTA parameters, including central foveal thickness (CFT), avascular zone (FAZ) area, FAZ perimeter, acircularity index (AI), density (FD300), vessel densities (VDs) superficial capillary plexus (SCP), deep (DCP), choriocapillaris analyzed a 6 × mm2 macular scan. Correlation multiple linear regression analyses conducted identify potential characteristics associated metrics. AI (P = 0.034) FD300 < 0.001) differed significantly between NLR control groups. The VD SCP parafovea DCP both 0.011) perifovea lower group than group. In analysis, reduced perifoveal was correlated increased international normalized ratio (standardized beta [STD β] − 0.356; P 0.047). Macular can be observed antecedent clinically visible lesions. Hematological disturbances may impairments preclinical leukemic retinopathy.

Language: Английский

Citations

2
Retinopathy in Metabolic Dysfunction-Associated Steatotic Liver Disease DOI Creative Commons
Myrsini Orfanidou, Stergios A. Pοlyzos

Medicina, Journal Year: 2024, Volume and Issue: 61(1), P. 38 - 38

Published: Dec. 30, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystemic disease, i.e., influencing various organ systems beyond the and, thus, contributing to comorbidities. Characterized by excessive fat accumulation in hepatocytes, MASLD frequently linked metabolic syndrome components, such as obesity, insulin resistance, dyslipidemia, and hypertension. Therefore, exploring intricate connection between other systems, including eyes, seems be essential. In this context, retinopathy has been investigated for its potential association with MASLD, since both conditions share common pathogenetic pathways. Chronic low-grade inflammation, oxidative stress, endothelial dysfunction are only some of those mechanisms progression possibly, determining bidirectional interplay retinal pathology. This narrative review aims summarize data concerning multisystemicity primarily focusing on eyes particularly, retinopathy. Identifying possible may emphasize need early screening integrated management approaches that address interconnected components within framework systemic disease. Further research necessary delineate precise develop targeted interventions mitigate impact aiming reduce overall burden improve patient outcomes.

Language: Английский

Citations

2
Research progress on pharmacological effects against liver and eye diseases of flavonoids present in Chrysanthum indicum L., Chrysanthemum morifolium Ramat., Buddleja officinalis Maxim. and Sophora japonica L. DOI

Suhui Xiong,

Jingchen Xie,

Feng Xiang

et al.

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 338, P. 119094 - 119094

Published: Nov. 10, 2024

Language: Английский

Citations

1
A novel approach: exploring the potential of retinal thickness and microvascular alterations for diagnosing cirrhosis DOI Creative Commons

Y Li,

Jie Zou, Xiaobing Jin

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 28, 2024

Abstract Background: The objective of this study was to investigate the correlation between fundus alterations and cirrhosis through use optical coherence tomography angiography (OCTA). Methods: This involved 17 patients with (34 eyes) healthy controls (HCs; 34 eyes). OCTA data were segmented into various layers regions categorized according subzones Early Treatment Diabetic Retinopathy Study for comparison. Results: Patients had a lower full retinal thickness (RT) in IS, OS, ON than did (HCs) (P < 0.001), RT also IN central (p<0.05). Additionally, inner layer IT, OT 0.05), outer IN, HCs 0.05). ROC curve IS region showed greater sensitivity pathological changes associated disease, an AUC 0.9324 (95% CI: 0.8665-0.9983). Furthermore, compared HCs, exhibited significantly superficial vessel density (SVD) 0.001) SVD IT 0.9429 0.8928–0.9930), indicating good diagnostic sensitivity. Conclusion: specific subregions macular retina those HCs. measurement could be valuable aid imaging patients.

Language: Английский

Citations

0