Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis DOI Creative Commons
Xin Su, Mi Bai,

Yaqiong Shang

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(12)

Published: Dec. 18, 2024

Abstract Acute kidney injury (AKI) is a significant global health issue, which often caused by cisplatin therapy and characterized mitochondrial dysfunction. Restoring homeostasis in tubular cells could exert therapeutic effects. Here, we investigated Slc25a21, carrier, as potential target for AKI intervention. Renal Slc25a21 expression negatively associated with function both patients cisplatin-induced murine models. Sustaining renal of slowed down progression reducing cellular apoptosis, necroptosis, the inflammatory response, likely through its regulation 2-oxoadipate conversion. highly expressed proximal epithelial cells, down-regulation contributes to compromised biogenesis integrity, well impaired oxidative phosphorylation. Mechanistically, reduced disrupts transport, affecting related metabolites influx tricarboxylic acid cycle. These findings demonstrate previously unappreciated metabolic suggest that targeting sustaining be novel strategy AKI.

Language: Английский

Principle role of the (pro)renin receptor system in cardiovascular and metabolic diseases: An update DOI

Mengzhi Zhu,

Xiaoli Yi, Shanshan Song

et al.

Cellular Signalling, Journal Year: 2024, Volume and Issue: 124, P. 111417 - 111417

Published: Sept. 23, 2024

Language: Английский

Citations

3
The role of JNK signaling pathway in organ fibrosis DOI Creative Commons

Zhouhui Yao,

Yandan Lu,

Pingping Wang

et al.

Journal of Advanced Research, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 1, 2024

Language: Английский

Citations

2
Aminopeptidasic Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events DOI Open Access

Noelia Rísquez Chica,

Elisa Pereira,

Francisco Manzano

et al.

Published: July 24, 2024

Background: Diagnosis of acute kidney injury (AKI) relies on serum creatinine (SCr) changes. This study investigated if urinary aminopeptidases are early and predictive biomarkers cardiac surgery associated-AKI (CSA-AKI). Methods: Glutamyl aminopeptidase (GluAp), alanyl (AlaAp), dipeptidyl peptidase-4 (DPP4), proteinuria, albuminuria, N-acetyl-β-D-glucosaminidase (NAG) neutrophile gelatinase-associated lipocalin (NGAL) were measured in urine samples from 44 patients at arrival Intensity Care Unit (ICU) after surgery. Sensitivity, specificity, positive negative value for diagnosis stages 1, 2 3 AKI analyzed the highest quartile each marker. We also studied relationship with SCr surgery, 6- 12-months glomerular filtration rate (GFR) other long-term events over next 5 years. Results: GluAp diagnosed maximal number that developed stage or AKI, increasing diagnostic sensitivity 0 to 75 %. Besides, DPP4 was related decrease GFR Conclusions: Urinary a potential tool CSA-AKI, being most effective marker diagnosing ICU admission. serve as GFR.

Language: Английский

Citations

1
Targeting programmed cell death in diabetic kidney disease: from molecular mechanisms to pharmacotherapy DOI Creative Commons

Fengzhao Liu,

Zhenyu Yang, Jixin Li

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Dec. 20, 2024

Abstract Diabetic kidney disease (DKD), one of the most prevalent microvascular complications diabetes, arises from dysregulated glucose and lipid metabolism induced by hyperglycemia, resulting in deterioration renal cells such as podocytes tubular epithelial cells. Programmed cell death (PCD), comprising apoptosis, autophagy, ferroptosis, pyroptosis, necroptosis, represents a spectrum demise processes intricately governed genetic mechanisms vivo. Under physiological conditions, PCD facilitates turnover cellular populations serves protective mechanism to eliminate impaired or cells, thereby preserving tissue homeostasis amidst hyperglycemic stress. However, existing research predominantly elucidates individual modes death, neglecting intricate interplay mutual modulation observed among various forms PCD. In this comprehensive review, we delineate diverse regulatory governing elucidate crosstalk dynamics distinct pathways. Furthermore, review recent advancements understanding pathogenesis explore their implications DKD. Additionally, potential natural products derived primarily botanical sources therapeutic agents, highlighting multifaceted effects on modulating crosstalk, proposing novel strategies for DKD treatment.

Language: Английский

Citations

1
Aminopeptidasic Enzymes as Early Biomarkers of Cardiac Surgery-Associated Acute Kidney Injury and Long-Term Events DOI Creative Commons

Noelia Rísquez Chica,

Elisa Pereira,

Francisco Manzano

et al.

Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1049 - 1049

Published: Aug. 24, 2024

Background: Diagnosis of acute kidney injury (AKI) relies on serum creatinine (SCr) changes. This study investigated if urinary aminopeptidases are early and predictive biomarkers cardiac surgery-associated AKI (CSA-AKI). Methods: Glutamyl aminopeptidase (GluAp), alanyl (AlaAp), dipeptidyl peptidase-4 (DPP4), proteinuria, albuminuria, N-acetyl-β-D-glucosaminidase (NAG), neutrophile gelatinase-associated lipocalin (NGAL) were measured in urine samples from 44 patients at arrival the intensive care unit (ICU) after surgery. Sensitivity, specificity, positive negative value for diagnosis stages 1, 2, 3 analyzed highest quartile each marker. We also studied relationship with SCr surgery, 6- 12-month glomerular filtration rates (GFRs), other long-term events over next 5 years. Results: GluAp diagnosed maximal number that developed stage 2 or AKI, increasing diagnostic sensitivity 0% to 75%. In addition, DPP4 related decrease GFR 6 12 months Conclusions: Urinary a potential tool CSA-AKI, being most effective marker diagnosing ICU admission. serve as GFR.

Language: Английский

Citations

0
Slc25a21 in cisplatin-induced acute kidney injury: a new target for renal tubular epithelial protection by regulating mitochondrial metabolic homeostasis DOI Creative Commons
Xin Su, Mi Bai,

Yaqiong Shang

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(12)

Published: Dec. 18, 2024

Abstract Acute kidney injury (AKI) is a significant global health issue, which often caused by cisplatin therapy and characterized mitochondrial dysfunction. Restoring homeostasis in tubular cells could exert therapeutic effects. Here, we investigated Slc25a21, carrier, as potential target for AKI intervention. Renal Slc25a21 expression negatively associated with function both patients cisplatin-induced murine models. Sustaining renal of slowed down progression reducing cellular apoptosis, necroptosis, the inflammatory response, likely through its regulation 2-oxoadipate conversion. highly expressed proximal epithelial cells, down-regulation contributes to compromised biogenesis integrity, well impaired oxidative phosphorylation. Mechanistically, reduced disrupts transport, affecting related metabolites influx tricarboxylic acid cycle. These findings demonstrate previously unappreciated metabolic suggest that targeting sustaining be novel strategy AKI.

Language: Английский

Citations

0