Supplementation with Essential Amino Acids in the Early Stage of Carbohydrate Reintroduction after a Very-Low Energy Ketogenic Therapy (VLEKT) Improves Body Cell Mass, Muscle Strength and Inflammation. DOI Creative Commons
Giuseppe Annunziata, Ludovica Verde,

Vincenzo D’Orsi

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Abstract Background Although little is yet known about the long-term maintenance of very low-energy ketogenic therapy (VLEKT) effects on body composition, muscle strength and inflammation, it plausible to assume that changes may occur, particularly during steps following step, due loss protective ketones concomitant reintroduction carbohydrates. For this reason, present study aimed evaluate supplementation with 8 g per day essential amino acids (EAAs) these parameters. Methods A total 68 women reproductive age grade I obesity who had completed 45 days phase VLEKT (KeNuT protocol) 40 non-ketogenic KeNuT protocol (phase 3, fruit reintroduction) were included in study. Half them (n = 34) followed first step re-educational EAAs (Aminotrofic®: 4 twice daily). Anthropometric parameters, composition via bioelectrical impedance analysis high-sensitivity C-reactive protein (hs-CRP) levels assessed at baseline, pre- post both dietary interventions. Results At end (before EAA supplementation), two groups did not differ any parameters assessed. phase, supplemented group showed greater magnitudes reduction weight, waist circumference, fat mass (FM) hs-CRP (p < 0.001 for all) increase 0.001), angle cell (BCM) (%) 0.001). Conclusion These results underline usefulness transitional improve (specifically FM BCM), strength, inflammatory status.

Language: Английский

Lifestyle Modifications and Nonpharmacological Treatments in Hidradenitis Suppurativa DOI
Caitlyn B. Dagenet, Lauren Gawey, Jennifer L. Hsiao

et al.

Dermatologic Clinics, Journal Year: 2025, Volume and Issue: 43(2), P. 273 - 284

Published: Jan. 8, 2025

Language: Английский

Citations

1
Supplementation with essential amino acids in the early stage of carbohydrate reintroduction after a very-low energy ketogenic therapy (VLEKT) improves body cell mass, muscle strength and inflammation DOI Creative Commons
Giuseppe Annunziata, Ludovica Verde,

Vincenzo D’Orsi

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Jan. 23, 2025

Although little is yet known about the long-term maintenance of very low-energy ketogenic therapy (VLEKT) effects on body composition, muscle strength and inflammation, it plausible to assume that changes may occur, particularly during steps following step, due loss protective ketones concomitant reintroduction carbohydrates. For this reason, present study aimed evaluate supplementation with 8 g per day essential amino acids (EAAs) these parameters. A total 68 women reproductive age grade I obesity who had completed 45 days phase VLEKT (KeNuT protocol) 40 non-ketogenic KeNuT protocol (phase 3, fruit reintroduction) were included in study. Half them (n = 34) followed first step re-educational EAAs (Aminotrofic®: 4 twice daily). Anthropometric parameters, composition via bioelectrical impedance analysis high-sensitivity C-reactive protein (hs-CRP) levels assessed at baseline, pre- post both dietary interventions. At end (before EAA supplementation), two groups did not differ any parameters assessed. phase, supplemented group showed greater magnitudes reduction weight, waist circumference, fat mass (FM) hs-CRP (p < 0.001 for all) increase 0.001), angle cell (BCM) (%) 0.001). These results underline usefulness transitional improve (specifically FM BCM), strength, inflammatory status.

Language: Английский

Citations

1
Beyond the skin: endocrine, psychological and nutritional aspects in women with hidradenitis suppurativa DOI Creative Commons
Anna Dattolo, Mónica Torres Sánchez, Evelyn Frías-Toral

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 10, 2025

Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory skin disorder that primarily affects body folds and the genital area, with higher prevalence in women across Europe. The pathogenesis of HS involves complex interplay intrinsic extrinsic factors, including genetics, immunity, hormones, environmental influences. frequently associated variety comorbidities, such metabolic, endocrine, gastrointestinal conditions, well mental health disorders. Although symptoms are generally similar both men women, female patients may experience exacerbations due to hormonal fluctuations during menstruation, pregnancy, breastfeeding, menopause. These changes require special consideration by clinicians when managing women. Due its nature frequent flare-ups, significantly impacts patients' quality life, affecting social interactions, emotional well-being, psychological health. Women sexual dysfunction, which further exacerbated burdens shame, loss femininity, diminished intimacy. This review highlights key aspects HS, extending beyond manifestations address psychological, nutritional population. It underscores importance multidisciplinary collaboration providing comprehensive care for this debilitating condition. Given limited largely off-label treatment options, holistic approach essential ensure an appropriate management.

Language: Английский

Citations

0
The Role of Sex in Body Composition Differences in Hidradenitis Suppurativa: Insights from Bioelectrical Impedance Analysis DOI Open Access
Zuzanna Piętowska,

Katarzyna Krefft-Trzciniecka,

Alicja Pakiet

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(8), P. 2760 - 2760

Published: April 17, 2025

Background: Hidradenitis suppurativa (HS) is a rare, debilitating, chronic inflammatory skin disease. This study aimed to investigate differences in body composition between patients with hidradenitis and healthy controls, particular focus on sex-specific disparities, while also exploring secondary associations muscle health quality of life. Methods: Body was measured using bioanalyzer compared HS individuals (n = 53) controls 50). Results: The mean BMI significantly higher the group than (median 29.6 vs. median 22.1; p < 0.001, effect size −0.581). had fat mass (mean 26.2 ± 22.7 16.3 6.0; −0.400), level visceral 9 2; −0.473), percentage total water 45.9 12.3 31.9 14.3; −0.508), skeletal index 8.9 7.3; −0.445), bone 3.2 2.5; −0.421); at same time, they lower predicted 19.8 47.3; −0.740) 38.2 7.8 42.3 5.5; 0.008, −0.263) comparison controls. characterized by metabolic age 65 21 years; −0.760) basal rate 1927 1489 kcal; −0.444). Conclusions: Patients exhibit distinctive pattern parameters when which may hold significant potential for enhancing diagnostic accuracy monitoring disease progression. highlighted composition, emphasizing need consider biological sex pathophysiology clinical evaluation HS. Further research needed explore utility analysis progression, therapeutic response, personalized management.

Language: Английский

Citations

0
The role of diet in managing hidradenitis suppurativa: a review of current evidence and future directions DOI
Nina Rossa Haddad

Archives of Dermatological Research, Journal Year: 2024, Volume and Issue: 316(8)

Published: Aug. 10, 2024

Language: Английский

Citations

1
Clinical Evaluation of Hovenia dulcis Extract Combinations for Effective Hangover Relief in Humans DOI Creative Commons
Ki Won Lee,

Guangpeng Xu,

Dong Hyun Paik

et al.

Foods, Journal Year: 2024, Volume and Issue: 13(24), P. 4021 - 4021

Published: Dec. 12, 2024

Alcohol consumption is associated with both short- and long-term adverse effects, including hangover symptoms. The objective of this study was to examine the potential benefits traditional beverages containing a combination Hovenia dulcis extract (HD) either Pueraria lobata (HDPB) or glutathione yeast (HDGB) in abbreviating alcohol intoxication mitigating A total 25 participants between ages 19 40 who had previously experienced were evaluated randomized, double-blind, crossover, placebo (PLA)-controlled clinical trial. Results showed that lower blood concentrations HDPB HDGB groups significantly than PLA group at 0.25 0.5 h, suggesting HD aids early metabolism (0 p < 0.05). Analysis hourly Acute Hangover Scale (AHS) all treatment reduced gastrointestinal disorder symptoms compared (p It can be confirmed improved by consuming drinks, apart from effect reducing acetaldehyde concentrations. Therefore, it predicted natural phytochemicals added safe for humans may help accelerate recovery

Language: Английский

Citations

1
The Impact of Diet on Hidradenitis Suppurativa Severity: A Cross-Sectional Case–Control Study DOI Creative Commons

Ferhan Kesik,

Sibel Doğan, Mehmet Fisunoğlu

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(12), P. 2107 - 2107

Published: Dec. 23, 2024

Background and Objectives: Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease primarily affecting hair follicles, characterized by painful nodules, abscesses, sinus tract formation. Recent evidence suggests that weight management nutritional factors may influence HS symptoms. This cross-sectional case–control study aimed to assess the impact of body composition on severity. Materials Methods: We included 50 patients with matched controls comparable in mass index (BMI), sex, age. The data collected 3-day food records, frequency questionnaire, 24 h physical activity Mediterranean Diet Adherence Screener (MEDAS) scores, composition, anthropometric measurements. macronutrient micronutrient intake, as well dietary glycemic (GI), were analyzed. severity was assessed using Hurley staging system International Suppurativa Severity Score System (IHS4). Results: exhibited significantly lower adherence diet higher GI compared controls. Their intake also reduced, while consumption junk food, dairy products, nightshade vegetables more frequent. MEDAS scores levels negatively correlated IHS4 measurements, energy, protein, total fat, showed positive correlations. stage positively visceral fat. In multiple regression analysis, score emerged primary variable associated Conclusions: These findings suggest an increased diet, GI, maintaining ideal affect management. Long-term studies are warranted corroborate our findings.

Language: Английский

Citations

1
Le patologie dermo-endocrine: quali ormoni e quali le possibili terapie DOI
Ludovica Verde, Giuseppe Annunziata, Silvia Savastano

et al.

L Endocrinologo, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 19, 2024

Citations

0
Integrative approaches in the management of hidradenitis suppurativa DOI

Sarah Hermak,

Hadar Lev‐Tov

Journal of the American Academy of Dermatology, Journal Year: 2024, Volume and Issue: 91(6), P. S42 - S45

Published: Dec. 1, 2024

Language: Английский

Citations

0
Unlocking the Mechanisms of Hidradenitis Suppurativa: Inflammation and miRNA Insights DOI Creative Commons

Emily Ames,

Maggie Sanders,

M.‐C. Jacobs

et al.

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2024, Volume and Issue: Volume 17, P. 2829 - 2846

Published: Dec. 1, 2024

Abstract: Inflammatory skin diseases impose a significant burden on patients and healthcare systems worldwide. Among these, hidradenitis suppurativa (HS) is particularly notable for its chronic recurrent nature. Recurrent nodules, abscesses, scarring in apocrine gland-rich areas characterize the disease, including groin, axillae, perianal regions. Despite considerable physical psychological impact, precise mechanisms driving HS remain elusive. Recent advancements understanding inflammatory processes involved have highlighted TNF-alpha, IL-1β, IL-17/IL-23 pathways, which play crucial roles initiating perpetuating disease. Moreover, specific microRNAs (miRNAs), such as miR-24-1-5p, miR146a-5p, mirR-26a-5p, miR-206, miR-338-3p, miR-338-5p, are these processes. Dysregulation of miRNAs contributes to aberrant cytokine expression persistent inflammation, foreseeably exacerbating disease progression. This narrative review hypothesizes that miRNA dysregulation triggers contributing HS's clinical manifestations We explore implicated miRNAs' potential biomarkers earlier detection novel therapeutic targets. Identifying offers new opportunities more accurate diagnosis, potentially allowing clinicians intervene before severe occur. Furthermore, strategies modulate could target pathways HS, leading personalized effective treatments. also discusses future research directions enhance management HS. A better involvement avenues management, ultimately improving patient outcomes quality life. Keywords: sebaceous glands, immunosuppressant drugs,

Language: Английский

Citations

0