Comprehensive bioinformatics analysis identifies biomarkers for cardiovascular risk in end-stage renal diseases DOI Creative Commons
Fangfang Lu

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Objective End-stage renal disease (ESRD) can increase the risk of cardiovascular (CV). We aimed to investigate pathways and mechanisms associated with potential protective genes linked CV (CVP). Methods conducted a systematic bioinformatics analysis using publicly available datasets from Gene Expression Omnibus (GEO). Differentially expressed (DEGs) were identified in patients ESRD without arrhythmia stringent statistical criteria. Functional enrichment analyses performed Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) elucidate biological roles these DEGs. Receiver Operating Characteristic (ROC) curve was used evaluate diagnostic performance biomarkers for prediction. Results Our revealed distinct set DEGs compared those arrhythmia. GO KEGG pathway indicated that involved key processes relevant disorders function, including wound healing, platelet activation, fluid-level regulation. Moreover, this study four downregulated (ABLIM3, TREML1, VCL, AVPR1A) two upregulated (BHLHA15 FZD8), which exhibited significant alterations expression levels, some showing robust discriminatory power, as evidenced by high Area Under Curve (AUC) values ROC predicting risks. Conclusion This panel (including miRNA an unknown gene) plasma may serve promising patients. These findings provide foundation future validation studies at integrating into clinical practice improve stratification management ESRD.

Language: Английский

Update of Aging Hallmarks in Idiopathic Pulmonary Fibrosis DOI Creative Commons
Ana Lilia Torres-Machorro,

Ángeles García-Vicente,

Marco Espina-Ordoñez

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(3), P. 222 - 222

Published: Feb. 5, 2025

Idiopathic Pulmonary Fibrosis (IPF) is an epithelial-driven interstitial lung disease of unknown etiology characterized by the excessive proliferation fibroblast populations that synthesize large amounts extracellular matrix. In this devastating disorder, all aging hallmarks appear prematurely or are altered. This review highlights key findings about IPF characteristics recently recognized as aging, including mechanical alterations, inflammaging, dysbiosis, alternative splicing, and disabled macroautophagy. It also revisits classic which encompass stem cell exhaustion, cellular senescence, altered intercellular communication. Enhancing our understanding fundamental processes underlie in may facilitate development innovative experimental strategies to improve therapeutic outcomes.

Language: Английский

Citations

0
Recent progress in exosomal non-coding RNAs research related to idiopathic pulmonary fibrosis DOI Creative Commons
Wei Yuan,

Min Cheol Hong,

Huiming Zhu

et al.

Frontiers in Genetics, Journal Year: 2025, Volume and Issue: 16

Published: March 27, 2025

Idiopathic Pulmonary Fibrosis (IPF) is a progressive interstitial lung disease characterized by unknown etiology and limited therapeutic options. Recent studies implicate exosomal non-coding RNAs (ncRNAs) as crucial regulators in IPF. These ncRNAs, including long (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are involved cellular processes through various mechanisms of selective packaging, intercellular communication, signaling pathway integration. LncRNAs such LINC00470 PVT1 exhibit pro-fibrotic effects, while others like lnc-DC THRIL show inhibitory roles; some, UCA1 MALAT1, demonstrate bidirectional regulation. In miRNAs, agents (e.g., miR-486, miR-223) contrast with miRNAs miR-34a, miR-126), miR-21 miR-155 display dual functions. Similarly, circRNAs circ_0000479 circ_0026344 promote fibrosis, whereas circ_0000072 circ_0000410 act inhibitors, certain circ_002178 circ_0001246) exhibiting complex regulatory effects. Exosomal ncRNAs modulate key pathways, TGF-β Wnt/β-catenin, influencing IPF progression. Despite their potential, challenges remain exosome isolation, functional characterization clinical translation. Addressing these barriers innovative research strategies essential to leverage the management treatment This review comprehensively examines roles IPF, elucidates interactions, discusses future perspectives enhance understanding for this disease.

Language: Английский

Citations

0
Emerging roles of noncoding RNAs in idiopathic pulmonary fibrosis DOI Creative Commons
Haitao Wang, Kai Sun, Hao Peng

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 21, 2024

Abstract Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic lung disease with limited treatment options and efficacy. Evidence suggests that IPF arises from genetic, environmental, aging-related factors. The pathogenic mechanisms of primarily involve dysregulated repeated microinjuries to epithelial cells, abnormal fibroblast/myofibroblast activation, extracellular matrix (ECM) deposition, but thus far, the exact etiology remains unclear. Noncoding RNAs (ncRNAs) play regulatory roles in various biological processes have been implicated pathophysiology multiple diseases, including IPF. This review summarizes ncRNAs pathogenesis their potential as diagnostic therapeutic targets.

Language: Английский

Citations

2
Exosome nanovesicles: biomarkers and new strategies for treatment of human diseases DOI Creative Commons

Chuan Xu,

Chaoyang Jiang, Zhihui Li

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(8)

Published: July 15, 2024

Exosomes are nanoscale vesicles of cellular origin. One the main characteristics exosomes is their ability to carry a wide range biomolecules from parental cells, which important mediators intercellular communication and play an role in physiological pathological processes. have advantages biocompatibility, low immunogenicity, biodistribution. As researchers' understanding has increased, various strategies been proposed for use diagnosing treating diseases. Here, we provide overview biogenesis composition exosomes, describe relationship between disease progression, focus on as biomarkers early screening, monitoring, guiding therapy refractory diseases such tumors neurodegenerative We also summarize current applications especially engineered efficient drug delivery, targeted therapies, gene immune vaccines. Finally, challenges potential research directions clinical application discussed. In conclusion, emerging molecule that can be used diagnosis treatment diseases, combined with multidisciplinary innovative solutions, will applications.

Language: Английский

Citations

2
Extracellular Vesicles in Idiopathic Pulmonary Fibrosis: Pathogenesis, Biomarkers and Innovative Therapeutic Strategies DOI Creative Commons
Yanbin Yang, Mengen Lv, Qingsong Xu

et al.

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 12593 - 12614

Published: Nov. 1, 2024

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and irreversible interstitial lung disease caused by aberrant deposition of extracellular matrix in the lungs with significant morbidity mortality. The therapeutic choices for IPF remain limited. Extracellular vesicles (EVs), as messengers intercellular communication, are cell-secreted lipid bilayer nanoscale particles found body fluids, regulate epithelial phenotype profibrotic signaling pathways transporting bioactive cargo to recipients pathogenesis IPF. Furthermore, an increasing number studies suggests that EVs derived from stem cells can be employed cell-free approach IPF, given their intrinsic tissue-homing capabilities regeneration characteristics. This review highlights new sights potential diagnostic prognostic biomarkers, prospects novel drug delivery systems next-generation therapeutics against Notably, bringing engineering strategies holds great promise enhancing effect anti-pulmonary promoting clinical transformation.

Language: Английский

Citations

0
Comprehensive bioinformatics analysis identifies biomarkers for cardiovascular risk in end-stage renal diseases DOI Creative Commons
Fangfang Lu

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Abstract Objective End-stage renal disease (ESRD) can increase the risk of cardiovascular (CV). We aimed to investigate pathways and mechanisms associated with potential protective genes linked CV (CVP). Methods conducted a systematic bioinformatics analysis using publicly available datasets from Gene Expression Omnibus (GEO). Differentially expressed (DEGs) were identified in patients ESRD without arrhythmia stringent statistical criteria. Functional enrichment analyses performed Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) elucidate biological roles these DEGs. Receiver Operating Characteristic (ROC) curve was used evaluate diagnostic performance biomarkers for prediction. Results Our revealed distinct set DEGs compared those arrhythmia. GO KEGG pathway indicated that involved key processes relevant disorders function, including wound healing, platelet activation, fluid-level regulation. Moreover, this study four downregulated (ABLIM3, TREML1, VCL, AVPR1A) two upregulated (BHLHA15 FZD8), which exhibited significant alterations expression levels, some showing robust discriminatory power, as evidenced by high Area Under Curve (AUC) values ROC predicting risks. Conclusion This panel (including miRNA an unknown gene) plasma may serve promising patients. These findings provide foundation future validation studies at integrating into clinical practice improve stratification management ESRD.

Language: Английский

Citations

0