The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair DOI Creative Commons
Sandra Díaz del Moral, Nicole Wagner, Kay‐Dietrich Wagner

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2078 - 2078

Published: Dec. 17, 2024

The Wilms’ tumor suppressor WT1 is essential for the development of heart, among other organs such as kidneys and gonads. Wt1 gene encodes a zinc finger transcription factor that regulates proliferation, cellular differentiation processes, apoptosis. also involved in cardiac homeostasis repair. In adulthood, WT1-expression levels are lower compared to those observed through development, expression restricted few cell types. However, its systemic deletion adult mice lethal, demonstrating presence key organ maintenance. response injury, epicardium re-activates WT1, but little known about roles it plays cardiomyocytes, which main type affected after myocardial infarction. fact cardiomyocytes exhibit low proliferation rate heart mammals highlights need explore new approaches regeneration. aim this review emphasize functions carried out by

Language: Английский

Small-molecule fluorescent probes for imaging and diagnosing ischemia-reperfusion injury DOI

Qingyuan Guo,

An Liu,

Yinghui Huang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110943 - 110943

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies DOI Creative Commons
Chen Chen, Guo-Hua Dai, Maoxia Fan

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 6, 2025

Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to global public health. It can result in myocardial cell damage and death due impaired mitochondrial endoplasmic reticulum (ER) functions. These two organelles are important regulators of death. In recent years, research shifted from isolated studies individual more integrative approach, with particular focus on their membrane contact sites-Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs). dynamic microdomains play crucial role regulating material exchange signal transduction between mitochondria. This review comprehensively describes intricate structure MAMs multifaceted roles cellular pathophysiological processes. Particular was directed at far-reaching effects key pathological events including calcium homeostasis, dysfunction, ER stress, oxidative autophagy ischemic heart (IHD). The potential treatment targets regulatory mechanisms were discussed summarized, providing novel directions approaches for improving ischemia-related diseases.

Language: Английский

Citations

0
The role of circ_0050908 in acute myocardial infarction (AMI) and its predictive value for AMI DOI Creative Commons
Song Quan, Fang Li, Rong Zhu

et al.

Journal of Cardiothoracic Surgery, Journal Year: 2025, Volume and Issue: 20(1)

Published: May 29, 2025

Language: Английский

Citations

0
Heavy mechanical force decelerates orthodontic tooth movement via Piezo1-induced mitochondrial calcium down-regulation DOI Creative Commons

Ye Zhu,

Xuehuan Meng,

Qiming Zhai

et al.

Genes & Diseases, Journal Year: 2024, Volume and Issue: 12(2), P. 101434 - 101434

Published: Sept. 15, 2024

Orthodontic tooth movement (OTM) depends on periodontal ligament cells (PDLCs), which sense biomechanical stimuli and initiate alveolar bone remodeling. Light (optimal) forces accelerate OTM, whereas heavy decelerate it. However, the mechanisms by PDLCs affect osteoclastic activities under different mechanical (MFs) remain unclear. This study demonstrates that mechanosensitive ion channel Piezo1-mediated Ca

Language: Английский

Citations

0
The Wilms’ Tumor Suppressor WT1 in Cardiomyocytes: Implications for Cardiac Homeostasis and Repair DOI Creative Commons
Sandra Díaz del Moral, Nicole Wagner, Kay‐Dietrich Wagner

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(24), P. 2078 - 2078

Published: Dec. 17, 2024

The Wilms’ tumor suppressor WT1 is essential for the development of heart, among other organs such as kidneys and gonads. Wt1 gene encodes a zinc finger transcription factor that regulates proliferation, cellular differentiation processes, apoptosis. also involved in cardiac homeostasis repair. In adulthood, WT1-expression levels are lower compared to those observed through development, expression restricted few cell types. However, its systemic deletion adult mice lethal, demonstrating presence key organ maintenance. response injury, epicardium re-activates WT1, but little known about roles it plays cardiomyocytes, which main type affected after myocardial infarction. fact cardiomyocytes exhibit low proliferation rate heart mammals highlights need explore new approaches regeneration. aim this review emphasize functions carried out by

Language: Английский

Citations

0