Current Insights into the Roles of LncRNAs and CircRNAs in Pulpitis: A Narrative Review DOI Open Access

Dulce Martha Fuchen-Ramos,

Ana Gabriela Leija-Montoya, Javier González-Ramírez

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13603 - 13603

Published: Dec. 19, 2024

Pulpitis, an inflammation of the dental pulp, is generated by bacterial invasion through different ways as caries. In establishment and development this disease, biological processes are involved. Long non-coding RNAs (lncRNAs) circular (circRNAs) transcripts with regulatory capacity participating in functions have been implicated diseases. The aim narrative review to critically analyze available evidence on role lncRNAs circRNAs pulpitis discuss possible new research prospects. LncRNAs involved were explored, addressing their expression, molecular mechanisms, targets effects studied animal vitro models, well studies human patients. emerging key regulators diverse including apoptosis, proliferation, differentiation, oxidative stress, autophagy, ferroptosis, immune response. mechanisms performed these (ncRNAs) interactions miRNAs formation networks context pulpitis. Further more deeply analyzing participation will reveal potential applications ncRNAs biomarkers or use therapeutic strategies pulp inflammation.

Language: Английский

Non-Coding RNAs in Cancer: Structure, Function, and Clinical Application DOI Open Access
Éva Márton, Alexandra Varga,

Dóra Domoszlai

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(4), P. 579 - 579

Published: Feb. 8, 2025

We are on the brink of a paradigm shift in both theoretical and clinical oncology. Genomic transcriptomic profiling, alongside personalized approaches that account for individual patient variability, increasingly shaping discourse. Discussions future cancer medicine mainly dominated by potential non-coding RNAs (ncRNAs), which play prominent role progression metastasis formation regulating expression oncogenic or tumor suppressor proteins at transcriptional post-transcriptional levels; furthermore, their cell-free counterparts might be involved intercellular communication. Non-coding considered to promising biomarker candidates early diagnosis as well therapeutic agents. This review aims provide clarity amidst vast body literature focusing diverse species ncRNAs, exploring structure, origin, function, applications miRNAs, siRNAs, lncRNAs, circRNAs, snRNAs, snoRNAs, eRNAs, paRNAs, YRNAs, vtRNAs, piRNAs. discuss molecular methods used detection functional studies vitro vivo. also address challenges must overcome enter new era therapy will reshape

Language: Английский

Citations

1
The roles of lncRNAs in the development of drug resistance of oral cancers DOI Open Access
Wenjing Wang, Yi Liu, Jianan Wu

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117458 - 117458

Published: Oct. 15, 2024

Language: Английский

Citations

5
An unbiased lncRNAs dropout CRISPR-Cas9 screen reveals RP11-350G8.5 as a novel therapeutic target for Multiple Myeloma DOI Creative Commons
Katia Grillone, Serena Ascrizzi, Paolo Cremaschi

et al.

Blood, Journal Year: 2024, Volume and Issue: 144(16), P. 1705 - 1721

Published: Aug. 19, 2024

Language: Английский

Citations

4
Non-Coding RNA as a Biomarker in Lung Cancer DOI Creative Commons

C. Raman Suri,

Shashikant Swarnkar,

L.V.K.S. Bhaskar

et al.

Non-Coding RNA, Journal Year: 2024, Volume and Issue: 10(5), P. 50 - 50

Published: Sept. 30, 2024

Introduction: Lung cancer remains one of the most prevalent and deadly cancers globally, with high mortality rates largely due to late-stage diagnosis, aggressive progression, frequent recurrence. Despite advancements in diagnostic techniques therapeutic interventions, overall prognosis for lung patients continues be dismal. Method: Emerging research has identified non-coding RNAs (ncRNAs), including microRNAs, long RNAs, circular as critical regulators gene expression, significantly influencing biology. These ncRNAs play pivotal roles various aspects pathogenesis, tumor initiation, metastasis, resistance therapy. Results: We provide a comprehensive analysis current understanding cancer, emphasizing their potential biomarkers early prognostication, prediction response. explore biological functions ncRNAs, involvement key oncogenic pathways, molecular mechanisms by which they modulate expression cellular processes cancer. Furthermore, this review highlights recent advances ncRNA-based tools strategies, such miRNA mimics inhibitors, lncRNA-targeted therapies, circRNA-modulating approaches, offering promising avenues personalized medicine. Conclusion: Finally, we discuss challenges future directions ncRNA research, need large-scale validation studies development efficient delivery systems therapies. This underscores revolutionize management providing novel options that could improve patient outcomes.

Language: Английский

Citations

4
Long Non-Coding RNAs in Ovarian Cancer: Mechanistic Insights and Clinical Applications DOI Open Access

Sneha Basu,

Revathy Nadhan, Danny N. Dhanasekaran

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(3), P. 472 - 472

Published: Jan. 30, 2025

Background/Objectives: Ovarian cancer is a leading cause of gynecological mortality worldwide, often diagnosed at advanced stages due to vague symptoms and the lack effective early detection methods. Long non-coding RNAs (lncRNAs) have emerged as key regulators in biology, influencing cellular processes such proliferation, apoptosis, chemoresistance. This review explores multifaceted roles lncRNAs ovarian pathogenesis their potential biomarkers therapeutic targets. Methods: A comprehensive literature was conducted analyze structural functional characteristics contributions biology. includes regulatory mechanisms, interactions with signaling pathways, implications for resistance. Advanced bioinformatics omics approaches were also evaluated lncRNA research. Results: The highlights dual role oncogenes tumor suppressors, modulating cell invasion, angiogenesis. Specific lncRNAs, HOTAIR GAS5, demonstrate significant diagnostic Emerging technologies, single-cell sequencing, provide valuable insights into microenvironment heterogeneity expression. Conclusions: LncRNAs hold transformative advancing diagnosis, prognosis, treatment. Targeting or associated pathways offers promising strategies overcome therapy resistance enhance personalized medicine. Continued research integrating will be essential unlock full clinical management.

Language: Английский

Citations

0
MicroRNAs as behind-the-scenes molecules in breast cancer metastasis and their therapeutic role through novel microRNA-based delivery strategies DOI

Mohamed J. Saadh,

Ashok Kumar Bishoyi, Suhas Ballal

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149272 - 149272

Published: Jan. 1, 2025

Language: Английский

Citations

0
Mechanisms behind the LncRNAs-mediated regulation of paclitaxel (PTX) resistance in human malignancies DOI
Ali G. Alkhathami,

Harikumar Pallathadka,

Sejal Shah

et al.

Experimental Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 114434 - 114434

Published: Feb. 1, 2025

Language: Английский

Citations

0
The Relevance of the Accurate Annotation of Micro and Long Non-Coding RNA Interactions for the Development of Therapies DOI Open Access
Simona Panni

Genes, Journal Year: 2025, Volume and Issue: 16(3), P. 262 - 262

Published: Feb. 24, 2025

A large fraction of the human genome is transcribed in RNA molecules that do not encode for proteins but have a crucial role regulating almost every level gene expression and, thus, define specific phenotype each cell. These non-coding RNAs include well-characterized microRNAs and thousands less-defined longer transcripts, named long RNAs. Both types markedly affect onset progression numerous pathologies, ranging from cancer to vascular neuro-degenerative diseases. In recent years, substantial effort has been made design drugs targeting ncRNAs, promising advancements produced micro-RNA mimics inhibitors. Each ncRNA controls several targets, overall effect its inhibition or overexpression depends on function set genes it regulates. Therefore, selecting most appropriate target, predicting final outcome ncRNA-based therapies, utilize detailed accurate knowledge their functional interactions. this review, I recapitulate principal resources which collect information microRNA lncRNA networks, focusing non-homogeneity data result disparate approaches. highlight identifiers interaction evidence standardization helping user filter integrate derived different databases reliable web regulative relations.

Language: Английский

Citations

0
Improvement of carboplatin chemosensitivity in lung cancer cells by siRNA-mediated downregulation of DLGAP1-AS2 expression DOI Creative Commons
Sania Ghobadi Alamdari, Reza Mohammadzadeh, Mohammad Amini

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 7, 2025

Despite being one of the primary and most effective treatments for advanced stages lung cancer, chemotherapy drugs like carboplatin have limitations due to their adverse side effects development drug resistance in cancer cells. However, recent studies shown promising results using small interfering RNAs (siRNAs) as a therapeutic agent treatment. Hence, this study aimed investigate potential combining siRNA-DLGAP1-AS2 with human cell lines. The viability cells was assessed MTT assay, apoptosis induction examined through Annexin V/Pi staining. Additionally, effect combination on cycle arrest colony formation studied. Furthermore, expression Bax, Bcl-2, MMP-2, MMP-9, GCLC, CD44 evaluated. Our functional analysis revealed that inhibiting DLGAP1-AS2 increased sensitivity carboplatin. Moreover, our demonstrated inhibition transfection treatment had tumor-suppressive function, progression proliferation A549 Therefore, it can be concluded targeting specific siRNA holds promise valuable approach cancer.

Language: Английский

Citations

0
MicroRNAs in the Diagnosis of Digestive Diseases: A Comprehensive Review DOI Open Access

Mirela Livia Popa,

Cristian Ichim,

Paula Anderco

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(6), P. 2054 - 2054

Published: March 18, 2025

MicroRNAs (miRNAs) have emerged as crucial regulators in digestive pathologies, including inflammatory bowel disease (miR-31, miR-155, and miR-21), colorectal cancer (miR-21, miR-598, miR-494), non-alcoholic fatty liver miR-192, miR-122). Their capacity to modulate gene expression at the post-transcriptional level makes them highly promising candidates for biomarkers therapeutic interventions. However, despite considerable progress, their clinical application remains challenging. Research has shown that miRNA is dynamic, varying across patients, stages, different intestinal regions. dual function both oncogenes tumor suppressors further complicates use, targeting miRNAs may yield unpredictable effects. Additionally, while miRNA-based therapies hold great potential, significant hurdles persist, off-target effects, immune activation, inefficiencies delivery methods. The intricate interplay between gut microbiota adds another layer of complexity, influencing mechanisms treatment responses. This review examined role emphasizing diagnostic potential. While they offer new avenues management, unresolved challenges underscore need research refine application.

Language: Английский

Citations

0