Admission Random Blood Glucose, Fasting Blood Glucose, Stress Hyperglycemia Ratio, and Functional Outcomes in Patients With Acute Ischemic Stroke Treated With Intravenous Thrombolysis

Frontiers in Aging Neuroscience, Journal Year: 2022, Volume and Issue: 14

Published: Feb. 8, 2022

Stress hyperglycemia ratio (SHR), calculated as glucose/glycated hemoglobin, has recently been developed for assessing stress and could provide prognostic information various diseases. However, calculating SHR using random blood glucose (RBG) drawn on admission or fasting (FBG) lead to different results. This study intends evaluate the association between functional outcomes in patients with acute ischemic stroke (AIS) recombinant tissue plasminogen activator (r-tPA) intravenous thrombolysis.Data from 230 AIS following thrombolytic therapy r-tPA Third Affiliated Hospital of Wenzhou Medical University April 2016 2019 were retrospectively reviewed. SHR1 was defined [RBG (mmol/L)]/[HbA1c (%)] SHR2 [FBG (%)]. The included early neurological improvement (ENI), poor function a modified Rankin Scale score (mRS) 3-6, all-cause death 3 months. Multivariable logistic regression performed estimate adverse outcomes.After adjustment possible confounders, though higher tend have risk outcome unlikely develop ENI, these did not reach statistical significance. In contrast, independently associated (per 0.1-point increases: odds ratios (OR) = 1.383 95% CI [1.147-1.668]). Further adjusted body mass index (BMI), triglyceride-glucose (TyG), diabetes slightly strengthen (both 1 2) outcomes. subgroup analysis, elevated is OR 1.246 [1.041-1.492]) non-diabetic individuals attenuated non-cardioembolic AIS.SHR expected replace concentration novel generation indicator potential therapeutic target.

Language: Английский

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Association of neutrophil to lymphocyte ratio, platelet to lymphocyte ratio, and monocyte to lymphocyte ratio with depression: A cross-sectional analysis of the NHANES data

Journal of Affective Disorders, Journal Year: 2022, Volume and Issue: 315, P. 168 - 173

Published: Aug. 4, 2022

Language: Английский

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Association Between the Children's Dietary Inflammatory Index (C-DII) and Markers of Inflammation and Oxidative Stress Among Children and Adolescents: NHANES 2015-2018

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: May 27, 2022

To explore the association of Children's Dietary Inflammatory Index (C-DII) scores with inflammation and markers inflammatory factors in children adolescents.Data on dietary nutrient intake, (ferritin, alkaline phosphatase, C-reactive protein (CRP), absolute neutrophil cell count lymphocyte count) oxidative stress (serum bilirubin, albumin, iron) were available for participants aged 6-19 years (n = 1281). Each participant's C-DII score was calculated based a 24-h diet recall. Generalized linear models applied to examine associations between stress, while adjusting covariates. Restricted cubic splines used dose-response indicators stress. Akaike's Information Criterionwas compare performance non-linear models.After potential confounders, quantile regression results showed that when comparing quartile 4 (most pro-inflammatory) 1 anti-inflammatory), lymphocytes, ferritin, CRP statistically significant differences serum albumin iron (P < 0.05). The relationship indicators. Overweight/obese adolescents who ate high pro-inflammatory more likely have higher levels cytokines 0.002).The index is associated chronic A resulted increased concentrations these markers, implying early interventions implications reducing adolescents.

Language: Английский

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The Association of the Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, Lymphocyte-to-Monocyte Ratio and Systemic Inflammation Response Index with Short-Term Functional Outcome in Patients with Acute Ischemic Stroke

Journal of Inflammation Research, Journal Year: 2023, Volume and Issue: Volume 16, P. 3619 - 3630

Published: Aug. 1, 2023

The aim of this study was to explore the relationship between functional prognosis and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), lymphocyte-to-monocyte (LMR) systemic inflammatory response index (SIRI) in patients with acute ischemic stroke (AIS) at discharge.A total 861 AIS were enrolled January 2019 December 2021. Blood cell counts collected on admission. Logistic regression analysis performed assess NLR, PLR, LMR, SIRI adverse outcomes (modified Rankin scale score 3-6) discharge. We also used receiver operating characteristic (ROC) curves estimate overall ability LMR judge short-term outcomes. Associations length hospital stay analyzed by Spearman correlation test.A 194 (22.5%) had poor Multivariate logistic showed that NLR (odds [OR], 1.060; 95% confidence interval [CI] 1.004-1.120, P=0.037), PLR (OR, 1.003; CI 1.000-1.005, P=0.018), 0.872; 0.774-0.981, P=0.023) 1.099; 1.020-1.184, P=0.013) independent factors for outcome. odds ratios highest versus lowest quartiles 2.495 (95% 1.394-4.466), 1.959 1.138-3.373) 1.866 1.106-3.146), respectively. quartile 2.300 1.331-3.975). areas under curve (AUCs) discriminate 0.644, 0.587, 0.628, 0.651, related (P<0.05).NLR, associated outcome discharge patients. hospitalization days AIS.

Language: Английский

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Association between Systemic Immune-Inflammation Index and Systemic Inflammation Response Index and Outcomes of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis

Annals of Indian Academy of Neurology, Journal Year: 2023, Volume and Issue: 26(5), P. 655 - 662

Published: July 20, 2023

Systemic immune-inflammation index (SII) and systemic inflammation response (SIRS) are being increasingly used to predict outcomes of various diseases. However, its utility for acute ischemic stroke (AIS) has not been established. Through this first systematic review meta-analysis, we aimed collate data on the prognostic ability SII SIRI predicting functional mortality after AIS. PubMed, CENTRAL, Scopus, Embase, Web Science were searched up January 5, 2023, studies reporting association between or Adjusted pooled in a random-effects model. Meta-regression was conducted variable cut-offs. Twelve included. Pooled analysis showed that high associated with poor AIS (OR: 2.35 95% CI: 1.77, 3.10 I2 = 44% P < 0.00001). an increasing effect size higher cut-off SII. Similarly, meta-analysis demonstrated patients at increased risk 1.69 1.08, 2.65 78% 0.02). No noted different cut-offs meta-regression. Data scarce but suggestive SIRI. can be patients. derive strong conclusions. Limited number important limitations need overcome by future studies.

Language: Английский

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The association between platelet-related parameters and nonalcoholic fatty liver disease in a metabolically healthy nonobese population

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 13, 2024

Abstract Nonalcoholic fatty liver disease (NAFLD) is the most common chronic characterized by subclinical inflammation and related to obesity metabolic syndrome (MS), but it also frequently observed in nonobese populations. We aimed evaluate relationship between white blood cell count-to-mean platelet volume ratio (WBC/MPV), platelet-to-lymphocyte count (PLR) lymphocyte-monocyte (LMR) association with NAFLD, considering presence of MS. Additionally, we investigate whether these parameters exhibited similar correlations dysfunction-associated steatotic (MASLD) as NAFLD. This cross-sectional study included subjects who underwent a comprehensive health evaluation, including tests abdominal ultrasonography. Subgroup analyses were conducted based on Out total 5929 (3271 males, mean age 49.7 ± 10.6 years), 2253 (38.0%) had WBC/MPV was significantly higher, PLR lower In analysis restricted (BMI < 25 kg/m 2 ) population without MS, both independently associated NAFLD: (adjusted OR 3.366; 95% CI 2.238–5.066) 0.997; 0.996–0.999). When assessing risk NAFLD quartiles, adjusted for lowest quartile compared highest 2.055 (95% 1.626–2.602) 0.660 0.523–0.832) nonobese, metabolically healthy group. The levels Furthermore, MASLD, an WBC/MPV, LMR identified, results even after adjusting confounding variables. conclusion, present demonstrated significant platelet-related parameters, especially subjects.

Language: Английский

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Association between immune-inflammation-based prognostic index and depression: An exploratory cross-sectional analysis of NHANES data

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 362, P. 75 - 85

Published: June 27, 2024

Language: Английский

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Higher fibrinogen and neutrophil-to-lymphocyte ratio are associated with the early poor response to intravenous thrombolysis in acute ischemic stroke

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 22, 2024

Background Inflammation and platelet activation play pivotal roles in acute ischemic stroke (AIS) pathogenesis. Early response to thrombolysis is a vital indicator for the long-term prognosis of AIS. However, correlation between fibrinogen or neutrophil-to-lymphocyte ratio (NLR) early intravenous patients with AIS remains unclear. Methods undergoing were enrolled January 2018 May 2023. Blood cell counts sampled before thrombolysis. A good was defined as National Institutes Health Stroke Scale (NIHSS) score decreased ≥4 complete recovery 24 h after treatment. poor any increase NIHSS decrease &lt;4 at treatment compared that admission. Logistic regression analysis performed explore relationship level NLR response. Receiver operating characteristic (ROC) used assess ability discriminate responders. Results Among 700 recruited patients, 268 (38.29%) diagnosed response, 432 (61.71%) binary logistic model indicated an elevated (odds [OR], 1.693; 95% confidence interval [CI] 1.325–2.122, P &lt; 0.001) (OR, 1.253; CI, 1.210–2.005, = independent factors The area under curve (AUC) values level, combined 0.708, 0.605, 0.728, respectively. Conclusions Our research indicates levels admission can be prognostic factor predict

Language: Английский

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Neutrophil to albumin ratio: a biomarker in non-alcoholic fatty liver disease and with liver fibrosis

Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11

Published: April 8, 2024

Objective Given the high prevalence of non-alcoholic fatty liver disease (NAFLD) and its potential to progress fibrosis, it is crucial identify presence NAFLD in patients guide their subsequent management. However, current availability non-invasive biomarkers for remains limited. Therefore, further investigation needed develop NAFLD. Methods A retrospective analysis was conducted on 11,883 admitted Healthcare Center, Union Hospital, Tongji Medical College, Huazhong University Science Technology, from January 2016 December 2019 divided into non-NAFLD groups. Anthropometric laboratory examination data were collected. The correlations between variables evaluated using student’s t-test or Mann–Whitney U test binary logistic regression analysis. predictive ability these assessed areas under curves (AUCs) receiver operating characteristics. Results Among included patients, 3,872 (32.58%) diagnosed with NAFLD, 386 (9.97%) individuals having fibrosis. Patients exhibited a higher proportion males, elevated body mass index (BMI), increased likelihood hypertension, diabetes mellitus, atherosclerosis. Logistic identified neutrophil albumin ratio (NAR) as most promising novel inflammation biomarkers, highest AUC value 0.701, cut-off 0.797, sensitivity 69.40%, specificity 66.00% identifying risk Moreover, NAR demonstrated superior at an 0.795, 71.30%, 73.60% when reached 1.285. Conclusion These findings highlight that inflammatory biomarker, NAR, convenient easily accessible predictor

Language: Английский

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Systemic immune-inflammation index is associated with white matter hyperintensity volume

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: May 5, 2022

Systemic immune-inflammation index (SII) is a novel inflammatory marker based on the composition ratio of blood cell counts. In this study, we evaluated association between SII and cerebral small vessel disease (cSVD) in health check-up participants. We participants from our registry 2006 2013. The was calculated using following formula: = (platelet count × neutrophil count)/lymphocyte count. cSVD assessed by considering white matter hyperintensity (WMH) volume, lacunes, microbleeds (CMBs). A total 3187 were assessed. multivariable linear regression analysis, significantly related to WMH volume [β 0.120, 95% confidence interval (CI) 0.050-0.189]. However, lacunes CMBs showed no statistical significance with SII. subgroup analysis age, associated only aged ≥ 60 years (β 0.225, CI 0.068-0.381). conclusion, high cSVD. Since more pronounced than or CMBs, might be closer inflammation-related pathological mechanisms.

Language: Английский

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