The Gut–Immune–Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease DOI Open Access
Rebecca Katharina Masanetz, Jürgen Winkler, Beate Winner

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(19), P. 11111 - 11111

Published: Sept. 21, 2022

Inflammatory bowel disease (IBD) comprises Crohn's (CD) and ulcerative colitis (UC) is associated with neuropsychiatric symptoms like anxiety depression. Both conditions strongly worsen IBD burden. In the present review, we summarize current understanding of pathogenesis depression in IBD. We a stepwise cascade along gut-immune-brain axis initiated by evasion chronic intestinal inflammation to pass epithelial vascular barrier gut cause systemic inflammation. then different anatomical transmission routes gut-derived peripheral into central nervous system (CNS) highlight knowledge on neuroinflammatory changes CNS preclinical mouse models focus microglia, brain-resident macrophages. Subsequently, discuss how neuroinflammation can alter neuronal circuitry trigger anxiety. Finally, role microbiota will be reviewed. A more comprehensive interaction between gastrointestinal tract, immune accounting for similarities differences UC CD pave path improved prediction treatment comorbidities other inflammatory diseases.

Language: Английский

Brain–gut–microbiota axis in depression: A historical overview and future directions DOI Creative Commons
Lijia Chang, Wei Yan, Kenji Hashimoto

et al.

Brain Research Bulletin, Journal Year: 2022, Volume and Issue: 182, P. 44 - 56

Published: Feb. 11, 2022

Depression is the most common mental disorder and a leading cause of disability worldwide. Despite abundant research, precise mechanisms underlying pathophysiology depression remain elusive. Accumulating evidence from preclinical clinical studies suggests that alterations in gut microbiota, microbe-derived short-chain fatty acids, D-amino acids metabolites play key role via brain–gut–microbiota axis, including neural immune systems. Notably, axis might crucial susceptibility versus resilience rodents exposed to stress. Vagotomy reported block depression-like phenotypes after fecal microbiota transplantation "depression-related" microbiome, suggesting vagus nerve influences through axis. In this article, we review recent findings regarding discuss its potential as therapeutic target for depression.

Language: Английский

Citations

246
Dual Role of Indoles Derived From Intestinal Microbiota on Human Health DOI Creative Commons
Xuewei Ye, Haiyi Li, Komal Anjum

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: June 17, 2022

Endogenous indole and its derivatives (indoles), considered as promising N-substituted heterocyclic compounds, are tryptophan metabolites derived from intestinal microbiota exhibit a range of biological activities. Recent studies indicate that indoles contribute to maintaining the barrier human intestine, which exert anti-inflammatory activities mainly through activating AhR PXR receptors affect immune system’s function, significantly improving health (inflammatory bowel disease, hemorrhagic colitis, colorectal cancer) further promote (diabetes mellitus, central system inflammation, vascular regulation). However, revealed toxic influences cannot be ignored. Indoxyl sulfate, an derivative, performs nephrotoxicity cardiovascular toxicity. We addressed interaction between indoles’ effects on double-edged swords. This review provides scientific bases for correlation with diseases moreover highlights several directions subsequent indoles-related studies.

Language: Английский

Citations

125
Oral polyphenol-armored nanomedicine for targeted modulation of gut microbiota–brain interactions in colitis DOI Creative Commons

Huan He,

Qiaozhen Qin, Fang Xu

et al.

Science Advances, Journal Year: 2023, Volume and Issue: 9(21)

Published: May 26, 2023

Developing oral nanomedicines that suppress intestinal inflammation while modulating gut microbiota and brain interactions is essential for effectively treating inflammatory bowel disease. Here, we report an polyphenol-armored nanomedicine based on tumor necrosis factor-α (TNF-α)-small interfering RNA gallic acid-mediated graphene quantum dot (GAGQD)-encapsulated bovine serum albumin nanoparticle, with a chitosan tannin acid (CHI/TA) multilayer. Referred to "armor," the CHI/TA multilayer resists harsh environment of gastrointestinal tract adheres inflamed colon sites in targeted manner. TA provides antioxidative stress prebiotic activities modulate diverse microbiota. Moreover, GAGQD protected TNF-α-siRNA delivery. Unexpectedly, armored suppressed hyperactive immune responses modulated bacterial homeostasis mouse model acute colitis. Notably, alleviated anxiety- depression-like behaviors cognitive impairment mice This armor strategy sheds light effect microbiome-brain interactions.

Language: Английский

Citations

75
Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease DOI Creative Commons
Colin F. Craig,

Rhiannon T. Filippone,

Rhian Stavely

et al.

Journal of Neuroinflammation, Journal Year: 2022, Volume and Issue: 19(1)

Published: Jan. 4, 2022

Abstract Patients with inflammatory bowel disease (IBD) suffer from depression at higher rates than the general population. An etiological trigger of depressive symptoms is theorised to be inflammation within central nervous system. It believed that heightened intestinal and dysfunction enteric system (ENS) contribute impaired permeability, which facilitates translocation enterotoxins into blood circulation. Consequently, these may compromise immunological physiological functioning distant non-intestinal tissues such as brain. In vivo models colitis provide evidence increased blood–brain barrier permeability enhanced (CNS) immune activity triggered by blood-borne mediators. Understanding immunological, physiological, structural changes associated IBD neuroinflammation aid in development more tailored suitable pharmaceutical treatment for IBD-associated depression.

Language: Английский

Citations

72
Role of Inflammatory Mechanisms in Major Depressive Disorder: From Etiology to Potential Pharmacological Targets DOI Creative Commons
Bruna R. Kouba, Laura A. Borba, Pedro Borges de Souza

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 423 - 423

Published: Feb. 28, 2024

The involvement of central and peripheral inflammation in the pathogenesis prognosis major depressive disorder (MDD) has been demonstrated. increase pro-inflammatory cytokines (interleukin (IL)-1β, IL-6, IL-18, TNF-α) individuals with depression may elicit neuroinflammatory processes inflammation, mechanisms that, turn, can contribute to gut microbiota dysbiosis. Together, neuroinflammation dysbiosis induce alterations tryptophan metabolism, culminating decreased serotonin synthesis, impairments neuroplasticity-related mechanisms, glutamate-mediated excitotoxicity. This review aims highlight inflammatory (neuroinflammation, dysbiosis) involved pathophysiology MDD explore novel anti-inflammatory therapeutic approaches for this psychiatric disturbance. Several lines evidence have indicated that addition antidepressants, physical exercise, probiotics, nutraceuticals (agmatine, ascorbic acid, vitamin D) possess effects their antidepressant properties. Further studies are necessary benefits these alternative therapies MDD.

Language: Английский

Citations

67
The gut-brain vascular axis in neuroinflammation DOI Creative Commons
Sara Carloni, María Rescigno

Seminars in Immunology, Journal Year: 2023, Volume and Issue: 69, P. 101802 - 101802

Published: July 7, 2023

The multifaceted microbiota characterizing our gut plays a crucial role in maintaining immune, metabolic and tissue homeostasis of the intestine as well distal organs, including central nervous system. Microbial dysbiosis is reported several inflammatory intestinal diseases characterized by impairment epithelial vascular barriers, defined leaky gut, it potential danger condition associated with development metabolic, neurodegenerative diseases. Recently, we pointed out strict connection between brain via novel axis. Here want to deepen knowledge on gut-brain axis, particular emphasis microbial dysbiosis, cerebral firm association axis will be summarized context protection, amelioration or boosting Alzheimer, Parkinson, Major depressive Anxiety disorders. Understanding relationship disease pathophysiology, mucosal barrier function host-microbe interaction foster use microbiome biomarker for health target therapeutic nutritional advances.

Language: Английский

Citations

59
The Tryptophan-Kynurenine Metabolic System Is Suppressed in Cuprizone-Induced Model of Demyelination Simulating Progressive Multiple Sclerosis DOI Creative Commons
Helga Polyák, Zsolt Galla, Nikolett Nánási

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(3), P. 945 - 945

Published: March 20, 2023

Progressive multiple sclerosis (MS) is a chronic disease with unique pattern, which histologically classified into the subpial type 3 lesions in autopsy. The lesion also homologous to that of cuprizone (CPZ) toxin-induced animal models demyelination. Aberration tryptophan (TRP)-kynurenine (KYN) metabolic system has been observed patients MS; nevertheless, KYN metabolite profile progressive MS remains inconclusive. In this study, C57Bl/6J male mice were treated 0.2% CPZ toxin for 5 weeks and then underwent 4 recovery. We measured levels serotonin, TRP, metabolites plasma brain samples at 1, 3, demyelination, 7 9 remyelination periods by ultra-high-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) after body weight measurement immunohistochemical analysis confirm development UHPLC-MS/MS measurements demonstrated significant reduction kynurenic acid, 3-hydoxykynurenine (3-HK), xanthurenic acid 3-HK, anthranilic week 5. Here, we show CPZ-induced mouse model Thus, potentially serves as biomarker thus opens new path toward planning personalized treatment, frequently obscured immunologic components deterioration.

Language: Английский

Citations

51
Role of Probiotics in Depression: Connecting Dots of Gut-Brain-Axis Through Hypothalamic-Pituitary Adrenal Axis and Tryptophan/Kynurenic Pathway involving Indoleamine-2,3-dioxygenase DOI
Sneha Tiwari, Vijay Paramanik

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

Citations

2
Targeting neuroinflammation by polyphenols: A promising therapeutic approach against inflammation-associated depression DOI Open Access
Mohammed Abu Tayab, Mohammad Nazmul Islam, Kazi Ashfak Ahmed Chowdhury

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2022, Volume and Issue: 147, P. 112668 - 112668

Published: Jan. 29, 2022

Depression is the most prevalent and debilitating mental disorder that affects a substantial number of people globally, hindering all aspects their lives leading to high suicides each year. Despite availability an array antidepressant medications, taking these medications does not relieve depressive symptoms in considerable patients, implying incomplete understanding pathomechanisms involved development depression. Besides that, subset those non-responsive patients exhibits increased systemic central inflammatory response, which has collectively led evolvement theory Indeed, peripherally generated mediators, as well insults within brain, can activate brain's resident immune cells, resulting neuroinflammatory response interferes with multitude neurobiological domains implicated pathogenesis Polyphenols, group plant-derived bioactive molecules, have been shown exert neuroprotective functions on brain by influencing neuropathological mechanisms, including neuroinflammation. From perspectives, this review mechanistically provides overview roles sustained depression elucidates therapeutic potential flavonoid nonflavonoid polyphenols modulating mediators signaling cascades promoting other neurophysiological underlying inflammation-associated symptoms. Therefore, given significant anti-neuroinflammatory effects, could be promising effective adjunctive therapy for treatment neuropsychiatric associated inflammation-related

Language: Английский

Citations

64
Molecular Basis Underlying the Therapeutic Potential of Vitamin D for the Treatment of Depression and Anxiety DOI Open Access
Bruna R. Kouba, Anderson Camargo, Joana Gil‐Mohapel

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(13), P. 7077 - 7077

Published: June 25, 2022

Major depressive disorder and anxiety disorders are common disabling conditions that affect millions of people worldwide. Despite being different disorders, symptoms depression frequently overlap in individuals, making them difficult to diagnose treat adequately. Therefore, compounds capable exerting beneficial effects against both special interest. Noteworthily, vitamin D deficiency has been associated with an increased risk developing anxiety, individuals these psychiatric have low serum levels this vitamin. Indeed, the last few years, gained attention for its many functions go beyond on calcium-phosphorus metabolism. Particularly, antioxidant, anti-inflammatory, pro-neurogenic, neuromodulatory properties seem contribute antidepressant anxiolytic effects. review, we highlight main mechanisms may underlie potential D. In addition, discuss preclinical clinical studies support therapeutic management disorders.

Language: Английский

Citations

40