Cells,
Journal Year:
2025,
Volume and Issue:
14(3), P. 222 - 222
Published: Feb. 5, 2025
Idiopathic
Pulmonary
Fibrosis
(IPF)
is
an
epithelial-driven
interstitial
lung
disease
of
unknown
etiology
characterized
by
the
excessive
proliferation
fibroblast
populations
that
synthesize
large
amounts
extracellular
matrix.
In
this
devastating
disorder,
all
aging
hallmarks
appear
prematurely
or
are
altered.
This
review
highlights
key
findings
about
IPF
characteristics
recently
recognized
as
aging,
including
mechanical
alterations,
inflammaging,
dysbiosis,
alternative
splicing,
and
disabled
macroautophagy.
It
also
revisits
classic
which
encompass
stem
cell
exhaustion,
cellular
senescence,
altered
intercellular
communication.
Enhancing
our
understanding
fundamental
processes
underlie
in
may
facilitate
development
innovative
experimental
strategies
to
improve
therapeutic
outcomes.
Microorganisms,
Journal Year:
2024,
Volume and Issue:
12(4), P. 775 - 775
Published: April 11, 2024
Immune
system
aging
is
becoming
a
field
of
increasing
public
health
interest
because
prolonged
life
expectancy,
which
not
paralleled
by
an
increase
in
expectancy.
As
age
progresses,
innate
and
adaptive
immune
systems
undergo
changes,
are
defined,
respectively,
as
inflammaging
senescence.
A
wealth
available
data
demonstrates
that
these
two
conditions
closely
linked,
leading
to
greater
vulnerability
elderly
subjects
viral,
bacterial,
opportunistic
infections
well
lower
post-vaccination
protection.
To
face
this
novel
scenario,
in-depth
assessment
the
players
involved
changing
epidemiology
demanded
regarding
individual
concerted
involvement
cells
mediators
within
endogenous
exogenous
factors
co-morbidities.
This
review
provides
overall
updated
description
changes
affecting
system,
may
be
help
understanding
underlying
mechanisms
associated
with
main
age-associated
infectious
diseases.
Advances in Nutrition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 100376 - 100376
Published: Jan. 1, 2025
Aging
is
associated
with
the
decline
of
tissue
and
cellular
functions,
which
can
promote
development
age-related
diseases
like
cancer,
cardiovascular
disease,
neurodegeneration,
disorders
musculoskeletal
immune
systems.
Healthspan
length
time
an
individual
in
good
health
free
from
chronic
disabilities
aging.
Two
modifiable
factors
that
influence
healthspan,
healthy
aging,
prevent
diseases,
are
diet
microbiota
gastrointestinal
tract
(gut
microbiota).
This
review
will
discuss
how
dietary
phytochemicals
gut
work
concert
to
a
First
overview
provided
influences
aging
through
its
impact
on
barrier
integrity,
function,
mitochondria
function
oxidative
stress.
Next,
mechanisms
by
effect
health,
inflammation,
nurture
diverse
microbial
composition
discussed.
Lastly,
directly
producing
bioactive
metabolites
food
urolithin
A,
equol,
hesperetin
sulforaphane.
These
other
phytochemical
derived
may
healthspan
Importantly,
individual's
capacity
produce
promoting
cruciferous
vegetables,
berries,
nuts,
citrus
soy
products
be
dependent
specific
bacteria
present
gut.
BMC Medicine,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 6, 2025
High
systolic
blood
pressure
(HSBP)
can
cause
adverse
cardiovascular
events
and
is
therefore
associated
with
a
heavy
global
disease
burden.
However,
this
burden
poorly
understood
in
youth
young
adults.
We
aimed
to
explore
population
better
understand
the
evolving
trends
HSBP-related
burden,
which
crucial
for
effectively
controlling
mitigating
harmful
effects.
This
systematic
analysis
used
data
from
2021
Global
Burden
of
Disease
Study,
spanning
1990–2021.
Participants
were
aged
15–39
years
204
countries/territories.
analysed
by
region,
sex,
age,
temporal
trends.
The
primary
outcomes
disability-adjusted
life
(DALYs),
mortality
rates,
estimated
annual
percentage
change.
Globally,
number
deaths
among
adults
has
increased
36.11%
(95%
uncertainty
interval
[95%
UI],
20.96–52.37%),
whereas
DALYs
37.68%
UI,
22.69–53.65%);
however,
DALY
rates
have
remained
relatively
stable.
In
2021,
4.29
3.29–5.28)
263.37
201.40–324.46)
per
100,000
population,
respectively.
overall
was
higher
males
than
females,
increasing
decreasing
Regionally,
significant
improvements
observed
most
high-sociodemographic
index
(SDI)
regions,
including
high-income
Asia
Pacific
(deaths:
change,
−
72.65%;
DALYs:
69.30%)
Western
Europe
72.89%;
67.48%).
contrast,
middle-SDI
regions
had
highest
low-middle-SDI
rates.
Furthermore,
low-SDI
experienced
largest
increase
DALYs.
age;
addition,
proportion
or
due
ischaemic
heart
stroke
reaching
>
75%
those
25
age.
indicates
that
current
preventative
efforts
are
insufficient.
Therefore,
targeted
measures
needed
counter
diseases
reduce
disparities
across
sexes.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 390 - 390
Published: Feb. 24, 2024
Aging
populations
worldwide
are
placing
age-related
diseases
at
the
forefront
of
research
agenda.
The
therapeutic
potential
natural
substances,
especially
propolis
and
its
components,
has
led
to
these
products
being
promising
agents
for
alleviating
several
cellular
molecular-level
changes
associated
with
diseases.
With
this
in
mind,
scientists
have
introduced
a
contextual
framework
guide
future
aging
research,
called
hallmarks
aging.
This
encompasses
various
mechanisms
including
genomic
instability,
epigenetic
changes,
mitochondrial
dysfunction,
inflammation,
impaired
nutrient
sensing,
altered
intercellular
communication.
Propolis,
rich
array
bioactive
compounds,
functions
as
potent
functional
food,
modulating
metabolism,
gut
microbiota,
immune
response,
offering
significant
health
benefits.
Studies
emphasize
propolis'
properties,
such
antitumor,
cardioprotective,
neuroprotective
effects,
well
ability
mitigate
oxidative
stress,
DNA
damage,
pathogenic
bacteria
growth.
article
underscores
current
scientific
evidence
supporting
role
controlling
molecular
characteristics
linked
hallmarks,
hypothesizing
geroscience
research.
aim
is
discover
novel
strategies
improve
quality
life
older
individuals,
addressing
existing
deficits
perspectives
area.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(28)
Published: Feb. 28, 2024
Musculoskeletal
diseases
and
injuries
are
among
the
leading
causes
of
pain
morbidity
worldwide.
Broad
efforts
have
focused
on
developing
pro-regenerative
biomaterials
to
treat
musculoskeletal
conditions;
however,
these
approaches
yet
make
a
significant
clinical
impact.
Recent
studies
demonstrated
that
immune
system
is
central
in
orchestrating
tissue
repair
targeting
responses
can
improve
biomaterial
therapeutic
outcomes.
However,
aging
critical
factor
negatively
affecting
function.
Hence,
understanding
how
age
affects
response
essential
for
improving
therapies.
This
review
focuses
intersection
repair.
The
article
introduces
general
impacts
physiology,
system,
biomaterials.
Then,
it
explains
adaptive
guides
injury
implants
cartilage,
muscle,
bone
discusses
processes
each
type.
concludes
by
highlighting
future
directions
development
translation
personalized
immunomodulatory
Immunology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 21, 2025
ABSTRACT
In
a
super‐aging
society,
the
increase
in
elderly
population
is
closely
tied
to
rise
infectious
diseases
due
factors
such
as
weakened
immune
systems
and
decreased
vaccine
efficacy
older
adults.
Various
opportunistic
pathogens
commonly
encountered
everyday
life
can
cause
infections
when
an
individual's
defence
aging.
These
underscore
importance
of
preventive
measures
against
pathogenic
aging
elderly.
The
response
acts
mechanism
foreign
substances,
including
abnormal
cells.
Specifically,
innate
body's
first
line
defence,
offering
rapid
nonspecific
pathogens.
Advances
study
immunity's
regulatory
functions
both
non‐immune
cells
have
broadened
our
understanding
responses'
impact
on
health.
This
includes
focus
effectors
like
antimicrobial
peptides
(AMPs)
their
potential
implications
for
health
longevity.
review
summarises
common
principles
evolutionary
adaptations
immunity
via
AMPs,
mammals
invertebrates.
Especially,
this
discusses
conserved
mechanisms
regulating
AMP
production
role
AMPs
modulating
from
invertebrate
human.
Therefore,
it
highlights
addressing
through
AMPs.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 359 - 359
Published: Feb. 4, 2025
The
investigation
of
biomarkers
for
metabolic
diseases
such
as
type
2
diabetes
mellitus
(T2DM)
and
dysfunction-associated
steatohepatitis
(MASH)
reveals
their
potential
advancing
disease
treatment
addressing
notable
overlap.
connection
between
MASH,
obesity,
T2DM
highlights
the
need
an
integrative
management
approach
mechanisms
like
insulin
resistance
chronic
inflammation.
Obesity
contributes
significantly
to
development
MASH
through
lipid
dysregulation,
resistance,
Selective
biomarker
targeting
offers
a
valuable
strategy
detecting
these
comorbidities.
Biomarkers
CRP,
IL-6,
TNF-α
serve
indicators
inflammation,
while
HOMA-IR,
fasting
insulin,
HbA1c
are
essential
evaluating
resistance.
Additionally,
triglycerides,
LDL,
HDL
crucial
comprehending
dysregulation.
Despite
growing
importance
digital
biomarkers,
challenges
in
research
methodologies
sample
variability
persist,
necessitating
further
studies
validate
diagnostic
tools
improve
health
interventions.
Future
opportunities
include
developing
non-invasive
panels,
using
multiomics,
machine
learning
enhance
prognoses
accuracy
therapeutic
outcomes.
