Diabetes
mellitus
is
a
multiple
etiology
syndrome,
caused
by
the
abscense
or
inability
of
insulin
to
properly
perform
its
functions
in
human
body.Among
complications,
diabetic
foot
one
most
frequent
and
harmful,
since
many
these
cases
eventually
advance
lower
limb
amputation.Among
consequences
this
surgical
measure,
several
impacts
on
patient's
life
were
identified,
such
as
socioeconomic,
involving
expensive
treatment,
prolonged
recurrent
hospitalizations,
physical
social
limitations,
which
may
lead
unemployment
reduced
productivity.Through
systematic
review
10
articles,
it
was
shown
that
prevalence
amputation
established
male
patients,
at
age
60
years
older,
widowed
divorced,
with
incomplete
formal
training
low
socio-demographic
status.According
review,
can
be
observed
factors
related
trauma,
improper
care,
inadequate
footwear,
skin
irritation
ulcers
are
responsible
for
development
foot.Moreover,
evidenced
that,
among
individuals
indicated
amputation,
them
already
knew
about
their
diabetes
diagnosis
more
than
five
others
only
found
have
after
formation
ulcers.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: July 1, 2024
The
applications
of
hydrogels
have
expanded
significantly
due
to
their
versatile,
highly
tunable
properties
and
breakthroughs
in
biomaterial
technologies.
In
this
review,
we
cover
the
major
achievements
potential
therapeutic
applications,
focusing
primarily
on
two
areas:
emerging
cell-based
therapies
promising
non-cell
modalities.
Within
context
cell
therapy,
discuss
capacity
overcome
existing
translational
challenges
faced
by
mainstream
therapy
paradigms,
provide
a
detailed
discussion
advantages
principal
design
considerations
for
boosting
efficacy
as
well
list
specific
examples
different
disease
scenarios.
We
then
explore
drug
delivery,
physical
intervention
therapies,
other
areas
(e.g.,
bioadhesives,
artificial
tissues,
biosensors),
emphasizing
utility
beyond
mere
delivery
vehicles.
Additionally,
complement
our
latest
progress
clinical
application
outline
future
research
directions,
particularly
terms
integration
with
advanced
biomanufacturing
This
review
aims
present
comprehensive
view
critical
insights
into
selection
both
tailored
meet
requirements
diverse
diseases
situations.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2771 - 2771
Published: Feb. 28, 2024
Early
gene
therapy
studies
held
great
promise
for
the
cure
of
heritable
diseases,
but
occurrence
various
genotoxic
events
led
to
a
pause
in
clinical
trials
and
more
guarded
approach
progress.
Recent
advances
genetic
engineering
technologies
have
reignited
interest,
leading
approval
first
product
targeting
mutations
2017.
Gene
(GT)
can
be
delivered
either
vivo
or
ex
vivo.
An
is
advantageous,
as
it
allows
characterization
gene-modified
cells
selection
desired
properties
before
patient
administration.
Autologous
also
used
during
this
process
which
eliminates
possibility
immune
rejection.
This
review
highlights
stages
therapy,
current
research
developments
that
increased
efficiency
safety
process,
comprehensive
summary
Human
Immunodeficiency
Virus
(HIV)
studies,
majority
employed
approach.
Retrovirology,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Jan. 23, 2024
Abstract
Chemokines
are
cytokines
whose
primary
role
is
cellular
activation
and
stimulation
of
leukocyte
migration.
They
perform
their
various
functions
by
interacting
with
G
protein-coupled
cell
surface
receptors
(GPCRs)
involved
in
the
regulation
many
biological
processes
such
as
apoptosis,
proliferation,
angiogenesis,
hematopoiesis
or
organogenesis.
contribute
to
maintenance
homeostasis
lymphocytes
coordinate
function
immune
system.
However,
chemokines
sometimes
hijacked
some
pathogens
infect
host
organism.
For
a
given
chemokine
receptor,
there
wide
structural,
organizational
conformational
diversity.
In
this
review,
we
describe
evidence
for
structural
variety
reported
receptor
CCR5,
how
variability
can
be
exploited
HIV-1
its
target
cells
what
therapeutic
solutions
currently
being
developed
overcome
problem.
Frontiers in Genome Editing,
Journal Year:
2024,
Volume and Issue:
6
Published: Feb. 1, 2024
Genome
editing
using
the
CRISPR/Cas
system
has
revolutionized
field
of
genetic
engineering,
offering
unprecedented
opportunities
for
therapeutic
applications
in
vivo
.
Despite
numerous
ongoing
clinical
trials
focusing
on
ex
genome
editing,
recent
studies
emphasize
promise
gene
technology.
However,
it
is
worth
noting
that
complete
attainment
inherent
capabilities
therapy
humans
yet
to
be
accomplished.
Before
full
realization
potential,
crucial
achieve
enhanced
specificity
selectively
targeting
defective
cells
while
minimizing
harm
healthy
cells.
This
review
examines
emerging
studies,
CRISPR/Cas-based
pre-clinical
and
innovative
approaches
a
wide
range
diseases.
Furthermore,
we
cancer-specific
sequences
target
genes
associated
with
tumors,
shedding
light
diverse
strategies
employed
cancer
treatment.
We
highlight
various
challenges
explore
their
prospective
translatability
overcome
these
obstacles.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2621 - 2621
Published: Feb. 23, 2024
Combination
antiretroviral
therapy
(cART)
has
significantly
improved
the
prognosis
of
individuals
living
with
human
immunodeficiency
virus
(HIV).
Acquired
syndrome
transformed
from
a
fatal
disease
to
treatable
chronic
infection.
Currently,
effective
and
safe
anti-HIV
drugs
are
available.
Although
cART
can
reduce
viral
production
in
body
patient
below
detection
limit,
it
cannot
eliminate
HIV
provirus
integrated
into
host
cell
genome;
hence,
will
be
produced
again
after
discontinuation.
Therefore,
research
cure
(or
remission)
for
been
widely
conducted.
In
this
review,
we
focus
on
drug
development
targeting
cells
latently
infected
assess
progress
including
our
current
studies,
particularly
terms
“Shock
Kill”,
“Block
Lock”
strategies.
Drug Delivery and Translational Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 20, 2025
Abstract
Using
the
knowledge
from
decades
of
research
into
RNA-based
therapies,
COVID-19
pandemic
response
saw
rapid
design,
testing
and
production
first
ever
mRNA
vaccines
approved
for
human
use
in
clinic.
This
breakthrough
has
been
a
significant
milestone
RNA
therapeutics
vaccines,
driving
an
exponential
growth
field.
The
development
novel
targeting
high-threat
pathogens,
that
pose
substantial
risk
to
global
health,
could
transform
future
health
delivery.
In
this
review,
we
provide
detailed
overview
two
interference
(RNAi)
pathways
how
antiviral
RNAi
therapies
can
be
used
treat
acute
or
chronic
diseases
caused
by
viruses
SARS-CoV-2
HIV,
respectively.
We
also
insights
short-interfering
(siRNA)
delivery
systems,
with
focus
on
lipid
nanoparticles
functionalized
achieve
targeted
specific
sites
disease.
review
will
current
developments
HIV
siRNAs,
highlighting
strategies
advance
progression
siRNA
along
clinical
pathway.
Graphical
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(7), P. 3184 - 3184
Published: March 29, 2025
Antiretroviral
therapy
(ART)
has
significantly
improved
the
prognosis
of
human
immunodeficiency
virus
type
1
(HIV-1)
infection.
Although
ART
can
suppress
plasma
viremia
below
detectable
levels,
it
cannot
eradicate
HIV-1
DNA
(provirus)
integrated
into
host
cell
genome.
This
integration
often
results
in
unrepaired
damage
due
to
HIV-1-induced
inhibition
repair
pathways.
Furthermore,
infection
causes
telomere
attrition
chromosomes,
a
critical
factor
contributing
CD4+
T
senescence
and
apoptosis.
proteins
induce
damage,
block
replication,
activate
responses
across
various
organs.
In
this
review,
we
explore
multiple
aspects
intricate
interactions
between
genome
involved
depletion,
inflammaging,
clonal
expansion
infected
cells
long-term-treated
patients,
viral
latency.
We
discuss
molecular
mechanisms
that
contribute
comorbidities
HIV-1-infected
individuals
highlight
emerging
therapeutic
strategies
targeting
provirus.
