Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 319 - 341
Published: Sept. 13, 2024
Language: Английский
Cancer Cell International, Journal Year: 2024, Volume and Issue: 24(1)
Published: Feb. 28, 2024
Cancer chemoresistance is a problematic dilemma that significantly restrains numerous cancer management protocols. It can promote recurrence, spreading of cancer, and finally, mortality. Accordingly, enhancing the responsiveness cells towards chemotherapies could be vital approach to overcoming chemoresistance. Tumour express high level sphingosine kinase-1 (SphK1), which acts as protooncogenic factor responsible for synthesis sphingosine-1 phosphate (S1P). S1P released through Human ATP-binding cassette (ABC) transporter interact with other phosphosphingolipids components in interstitial fluid tumor microenvironment (TME), provoking communication, progression, invasion, metastasis. Also, associated several impacts, including anti-apoptotic behavior, metastasis, mesenchymal transition (EMT), angiogenesis, chemotherapy resistance. Recent reports addressed levels carcinomas, ovarian, prostate, colorectal, breast, HCC. Therefore, targeting S1P/SphK signaling pathway an emerging therapeutic efficiently attenuate In this review, we comprehensively discussed functions, metabolism, transport, signaling. bioinformatic framework, pointed out alterations SphK1 gene expression within different cancers their impact on patient survival, demonstrated protein-protein network SphK1, elaborating its sparse roles. Furthermore, made emphasis machineries resistance tight link S1P. We evaluated all publicly available inhibitors inhibition activity using molecular docking how reduce production might chemoresistance, course treatment prognosis.
Language: Английский
Citations
30
BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)
Published: Feb. 6, 2024
Recently, COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants, > 6 million deaths. Symptoms included strain complications, leading to pneumonia. SARS-CoV-2 attaches the ACE-2 receptor of host cell membrane enter. Targeting entry may effectively inhibit infection. Acid sphingomyelinase (ASMase) is a lysosomal protein that catalyzes conversion sphingolipid (sphingomyelin) ceramide. Ceramide molecules aggregate/assemble on plasma form "platforms" facilitate viral intake into cell. Impairing ASMase activity will eventually disrupt In this review, we identified metabolism sphingolipids, sphingolipids' role in signal transduction cascades, infection mechanisms. Also, outlined structure underlying mechanisms inhibiting 40 with aid inhibitors acid (FIASMAs). silico molecular docking analyses FIASMAs revealed dilazep (S = - 12.58 kcal/mol), emetine 11.65 pimozide 11.29 carvedilol 11.28 mebeverine 11.14 cepharanthine 11.06 hydroxyzin 10.96 astemizole 10.81 sertindole 10.55 bepridil 10.47 kcal/mol) have higher inhibition than candidate drug amiodarone 10.43 making them better options for inhibition.
Language: Английский
Citations
6
Pharmacological Research - Natural Products, Journal Year: 2025, Volume and Issue: unknown, P. 100208 - 100208
Published: March 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16
Published: April 25, 2025
Chemotherapeutic resistance is a major obstacle to chemotherapeutic failure. Cancer cell involves several mechanisms, including epithelial-to-mesenchymal transition (EMT), signaling pathway bypass, drug efflux activation, and impairment of entry. P-glycoproteins (P-gp) are an transporter that pumps drugs out cancer cells, resulting in resistance. Several types long noncoding RNA (lncRNAs) have been identified resistant ODRUL, MALAT1, ANRIL. The high expression level ODRUL related the induction ATP-binding cassette (ABC) gene expression, emergence doxorubicin osteosarcoma. lncRNAs observed be regulators transporters cells such as MALAT1 Targeting P-gp using natural products new strategy overcome improve sensitivity toward chemotherapies. This review validates inhibitory effects on activity silico molecular docking. In analysis showed Delphinidin Asparagoside-f most significant product inhibitors p-glycoprotein-1. These can reverse multi-drug induce chemotherapy based It important validate pre-elementary docking confirmed vitro vivo experimental data.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(24), P. 17162 - 17162
Published: Dec. 5, 2023
The global coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has become greatest worldwide public health threat of this century, which may predispose multi-organ failure (especially lung) and death despite numerous mild moderate symptoms. Recent studies have unraveled molecular clinical characteristics infectivity, pathogenicity, immune evasion SARS-CoV-2 thus improved development many different therapeutic strategies to combat COVID-19, including treatment prevention. Previous indicated that nitric oxide (NO) is an antimicrobial anti-inflammatory molecule with key roles in pulmonary vascular function context viral infections other states. This review summarized recent advances pathogenesis SARS-CoV-2, accordingly elaborated on potential application NO management patients COVID-19 through antiviral activities properties, mitigate propagation disease. Although there are some limits it might be a worthy candidate multiple stages prevention or therapy.
Language: Английский
Citations
8
Polyhedron, Journal Year: 2024, Volume and Issue: 255, P. 116954 - 116954
Published: March 30, 2024
Language: Английский
Citations
2
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: Jan. 15, 2024
Abstract A comprehensive investigation into the green synthesis of metal oxide nanoparticles (NPs) has garnered significant attention due to its commendable reliability, sustainability, and environmentally friendly attributes. Green methods play a crucial role in mitigating adverse effects associated with conventional approaches employed for nanostructure preparation. This research endeavors examine impact ginger plant extract-assisted oxides NPs on serum ferritin levels anemic diabetic patients vitro, focusing specifically α-Fe 2 O 3 ZnO NPs. Sixty volunteers anemia (35–50 years) thirty healthy were enrolled as controls. The assessment was conducted using VIDAS Ferritin (FER) assay. Photoluminescence (PL) spectroscopy measurements performed elucidate intrinsic extrinsic transitions these NPs, affirming successful formation α-structured iron oxide. Density functional theory (DFT) calculations carried out at B3LYP/6-311++G(d,2p) level investigate geometry optimization molecular electrostatic potential maps Furthermore, TD-DFT explore their frontier orbitals various quantum chemical parameters. binding affinity interaction types active site human H-Chain (PDB ID: 2FHA) target determined help docking. Results unveiled crystalline structure α-structure . Analysis dipole moment values demonstrated that (total (D) = 5.80 µ) exhibited superior reactivity, biological activity, stronger interactions diverse force fields compared (D 2.65 µ). Molecular docking H-chain provided evidence robust hydrogen bond metal-acceptor bonds between protein. finding could have great NPs-ferritin therapeutic protein, however, further studies toxicity are required. Graphical abstract
Language: Английский
Citations
1
Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15
Published: Oct. 9, 2024
Background The coronavirus disease (COVID-19) pandemic has presented unprecedented stressors and difficulties for healthcare professionals. This study explored the prevalence of generalized anxiety disorders burnout among radiology practitioners interns in various hospitals Saudi Arabia after end COVID-19 global public health emergency. Methods A cross-sectional survey 230 was conducted between October November 2023. utilized Generalized Anxiety Disorder 7-item (GAD-7) scale Maslach Burnout Inventory-Human Services Survey Medical Personnel (MBI-HSS-MP) 22-item questionnaire, employing a non-probability convenience sampling method. average scores individual components constituting GAD-7 each were calculated, statistical analyses using Mann-Whitney U Kruskal-Wallis H nonparametric tests. Results Of 382 interns, (60.2%) responded to survey. Notably, 42.6% participants reported experiencing GAD. Regarding burnout, 82.3% at moderate-to-high risk emotional exhaustion, 93.5% depersonalization, 52.1% personal achievement. 31–40 years age group showed significantly higher rates (p = 0.001) compared with other groups. Those more than three experience had notably exhaustion 0.002) nearly significant increase depersonalization 0.051) those less experience. Discussion Our revealed that experienced GAD, majority facing burnout. Furthermore, our research indicates decline GAD levels peak period. It also both incidence severity surpassing pre-pandemic comparable cohort. These findings emphasize pressing challenges workers, especially
Language: Английский
Citations
1
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: July 29, 2024
Rhinoviruses (RVs) cause upper respiratory tract infections and pneumonia in children adults. These non-enveloped viruses contain viral coats of four capsid proteins: VP1, VP2, VP3, VP4. The canyon on VP1 used cell surface receptor ICAM-1 as the site attachment for internalization viruses. To date, there has been no drug or vaccine available against RVs. In this study, bioactive natural compounds rosemary (Salvia rosmarinus L.), which are known their pharmacological potential, were considered to target protein. A total 30 taken ligands proteins. PkCSM tool was detect adherence Lipinski's rule five ADMET properties selected ligands. Further, CB-Dock molecular docking studies between protein Based profiling results, phenethyl amine (4 methoxy benzyl) lead compound. comparative study performed compound two antiviral drugs, Placonaril Nitazoxanide, investigate higher potential over synthetic drugs. also targets but failed clinical trials while Nitazoxanide examined rhinoviruses. It discovered from that exhibited less toxicity comparison other tested drugs More research is needed determine its make it a good medication
Language: Английский
Citations
0
Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107776 - 107776
Published: Sept. 3, 2024
Language: Английский
Citations
0