Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism DOI Creative Commons
Shih‐Yen Lo,

Meng‐Jiun Lai,

Chee-Hing Yang

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1412 - 1412

Published: Sept. 3, 2024

Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide (RNR), SAM HD domain-containing protein 1 (SAMHD1), among others. DHFR is vital de novo synthesis purines deoxythymidine monophosphate, which necessary DNA synthesis. SAMHD1, a ubiquitously expressed deoxynucleotide triphosphohydrolase, converts dNTPs into deoxynucleosides inorganic triphosphates. This process counteracts primarily carried out by RNR deoxynucleoside kinases, most active during S phase cell cycle. intracellular levels can influence various viral infections. review provides concise summary interactions between different viruses genes involved in metabolism.

Language: Английский

SAMHD1 enhances HIV-1-induced apoptosis in monocytic cells via the mitochondrial pathway DOI Creative Commons
Hua Yang, Pak‐Hin Hinson Cheung, Li Wu

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

SUMMARY Sterile alpha motif (SAM) and histidine-aspartate (HD) domain-containing protein 1 (SAMHD1) inhibits HIV-1 replication in non-dividing cells by reducing the intracellular dNTP pool. SAMHD1 enhances spontaneous apoptosis cells, but its effects on HIV-1-induced underlying mechanisms remain unknown. Here we uncover a new mechanism which monocytic through mitochondrial pathway. We found that endogenous levels induced infection dividing THP-1 cells. Mechanistically, expression decreases membrane potential promotes cytochrome c release thereby enhancing apoptotic SAMHD1-enhanced is associated with increased of pro-apoptotic BCL-2-interacting killer (BIK) further demonstrated BIK contributes to during infection. Overall, our results reveal an unappreciated regulatory via pathway

Language: Английский

Citations

0
PA and PA-X: two key proteins from segment 3 of the influenza viruses DOI Creative Commons
Xin Zhang,

Yingying Tao,

Li Wu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: March 14, 2025

In recent years, the influenza viruses have posed an increasingly severe threat to public health. It is essential analyze virulence and pathogenesis of prevent control them, as well create antiviral drugs. Previous studies revealed that virus segment 3 codes for not only PA protein but also a novel protein, PA-X. one subunit polymerase plays critical role in its life cycle. presented endonuclease activity, transcription replication viral genome, virulence, degradation, host immune response by interacting with proteins, including PB2, PB1, factors, ANP32A, CHD6, HAX1, hCLE, HDAC6, MCM complex. mutations were involved replication, pathogenicity, transmission poultry, mammals, humans. PA-X open reading frame generated +1 ribosomal code shift at N-terminal amino acids possesses shutoff activity gene expression, regulating response, transmission. Therefore, ideal target development drugs against viruses. Baloxavir marboxil (BXM) Favipiravir are two very effective anti-influenza targeting domain A this review, we summarized structures, virulent determinants transmission, innate immunity, The information great value underlying mechanism developing strategies infection pandemic.

Language: Английский

Citations

0
Recent Insights into the Molecular Mechanisms of the Toll-like Receptor Response to Influenza Virus Infection DOI Open Access
Mohammad Enamul Hoque Kayesh, Michinori Kohara,

Kyoko Tsukiyama–Kohara

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(11), P. 5909 - 5909

Published: May 29, 2024

Influenza A viruses (IAVs) pose a significant global threat to human health. tightly controlled host immune response is critical avoid any detrimental effects of IAV infection. It investigate the association between Toll-like receptors (TLRs) and influenza virus. Because TLRs may act as double-edged sword, balanced TLR for overall benefit host. Consequently, thorough understanding essential targeting novel therapeutic prophylactic intervention. To date, limited number studies have assessed interactions. Therefore, further research on interactions in infection should be conducted determine their role host–virus disease causation or clearance Although virus vaccines are available, they efficacy, which enhanced improve efficacy. In this study, we discuss current status our strategies adopted by IAVs TLR-mediated surveillance, help devising new preventive strategies. Furthermore, recent advances use agonists vaccine adjuvants enhance efficacy discussed.

Language: Английский

Citations

3
Unveiling the Connection: Viral Infections and Genes in dNTP Metabolism DOI Creative Commons
Shih‐Yen Lo,

Meng‐Jiun Lai,

Chee-Hing Yang

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1412 - 1412

Published: Sept. 3, 2024

Deoxynucleoside triphosphates (dNTPs) are crucial for the replication and maintenance of genomic information within cells. The balance dNTP pool involves several cellular enzymes, including dihydrofolate reductase (DHFR), ribonucleotide (RNR), SAM HD domain-containing protein 1 (SAMHD1), among others. DHFR is vital de novo synthesis purines deoxythymidine monophosphate, which necessary DNA synthesis. SAMHD1, a ubiquitously expressed deoxynucleotide triphosphohydrolase, converts dNTPs into deoxynucleosides inorganic triphosphates. This process counteracts primarily carried out by RNR deoxynucleoside kinases, most active during S phase cell cycle. intracellular levels can influence various viral infections. review provides concise summary interactions between different viruses genes involved in metabolism.

Language: Английский

Citations

2