Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition DOI Creative Commons
Mina Yekani,

Masoumeh Dastgir,

Samaneh Fattahi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 8, 2025

Periodontitis (PD) is the most common oral infectious disease. The primary etiologic cause of onset and development PD dental plaque, which consists bacterial biofilm domiciled within a complex extracellular mass. In patients, there progressive breakdown periodontal ligament alveolar bone. more advanced stages, tooth loss occurs. progression this chronic inflammatory disease involves interactions among numerous microbial pathogens particularly, bacteria, host’s immune factors, various environmental factors. Due to persistent infection by periodonto-pathogenic an impairment both innate acquired immunity, leading tissue destruction. Chronic inflammation in may be associated with several systemic diseases, including cardiovascular conditions, respiratory issues, diabetes, neurological cancer, adverse pregnancy outcomes. Antibiotic treatment one effective strategies for treating cases, although emergence some resistant strains limit effectiveness antibiotics. review study, we discussed main bacteria PD, interaction response, pathogenesis antibiotic treatment. We also outlined resistance antibiotics these pathogens.

Language: Английский

Cariogenic Microbiota and Emerging Antibacterial Materials to Combat Dental Caries: A Literature Review DOI Creative Commons
Jingwei Cao, Qizhao Ma, Jia Shi

et al.

Pathogens, Journal Year: 2025, Volume and Issue: 14(2), P. 111 - 111

Published: Jan. 23, 2025

Dental caries is the most common oral disease in world and a chronic infectious disease. The cariogenic microbiome plays an important role process of caries. ecological imbalance microbiota leads to low pH, which causes Therefore, antibacterial materials have always been hot topic. Traditional such as cationic agents, metal ion some natural extract agents good effects. However, they can cause bacterial resistance poor biological safety when used for long-term purposes. Intelligent materials, pH-responsive nanozymes, photoresponsive piezoelectric living are emerging nano-strategies that respond microenvironment or other specific stimuli exert Compared with traditional these less prone resistanceand safety. This review summarizes characteristics materials. These accurately act on microenvironment, showing intelligent effects providing new ideas management.

Language: Английский

Citations

1
Re-Emergence of Bacteriophages and Their Products as Antibacterial Agents: An Overview DOI Open Access
Vipin Chandra Kalia, Sanjay K. S. Patel, Chunjie Gong

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(4), P. 1755 - 1755

Published: Feb. 19, 2025

Microbes possess diverse genetic and metabolic traits that help them withstand adverse conditions. Microbial pathogens cause significant economic losses around 7.7 million human deaths annually. While antibiotics have historically been a lifesaving treatment, their effectiveness is declining due to antibiotic-resistant strains, prompting the exploration of bacterial predation as an alternative. Bacteriophages (BPhs) reemerged antibacterial agents, offering advantages over antibiotics, such (i) high specificity, (ii) self-replication, (iii) strong killing capacity. This review explores BPh- enzyme-based strategies for infectious disease discussing phage-antibiotic synergy, risks BPh resistance, role quorum sensing in therapy.

Language: Английский

Citations

0
Advanced biomaterials for targeting mature biofilms in periodontitis therapy DOI
Jie Tao,

Yirong Sun,

Guoliang Wang

et al.

Bioactive Materials, Journal Year: 2025, Volume and Issue: 48, P. 474 - 492

Published: Feb. 27, 2025

Language: Английский

Citations

0
Is the oral pathogen, Porphyromona gingivalis, associated to colorectal cancer?: a systematic review DOI Creative Commons
Antonio Navarro‐Sánchez,

María Ángeles Nieto-Vitoria,

José A López-López

et al.

BMC Cancer, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 4, 2025

The association between the oral pathogen Porphyromonas gingivalis (PG) and gut microbiota in colorectal cancer (CRC) patients has been explored with inconsistent results. This study aims to systematically assess this potential association. A systematic review was conducted across three databases (Pubmed, Embase Web of Science) from inception up January 2023 updated until November 2024. Inclusion criteria were observational studies examining PG adults CRC compared healthy controls. Exclusion without control group individuals, other designs or full-text access. Two reviewers independently selected extracted data following a pre-registered protocol. Disagreements resolved by consensus third reviewer. Risk bias (RoB) assessed using Newcastle-Ottawa Scale (NOS). Results summarized flow diagram, tables, narrative descriptions. Meta-analysis not feasible, so Fisher's method for combining p-values sign test used as alternative integration methods. Finally, 18 studies, 23 analysis units included, providing total sample 4,373 participants (48.0% cases 52.0%controls), 38.2% men 61.8% women, similar distribution among mean (SD) age 63.3 (4.382) years old 57.0 (7.753) Most analyzed presence feces (70.0%) collected before colonoscopy (55.0%) classified good quality RoB assessment. suggested an effect (Fisher's test, p = .000006) some evidence towards positive controls (Sign .039). suggest that is associated patients. Lack information calculate size prevented performance meta-analysis. Future research should aim standardized protocols statistical approaches. No funding received work. protocol registered International Prospective Register Systematic Reviews (PROSPERO) on (registration number: CRD42023399382).

Language: Английский

Citations

0
Bacteriophage-Based Therapies in Oral Cancer: A New Frontier in Oncology DOI Creative Commons

Vishnu Priya Panneerselvam,

Leela Kagithakara Vajravelu,

Rahul Harikumar Lathakumari

et al.

Cancer Pathogenesis and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Acquired CRISPR spacers and rhamnose-glucose polysaccharide defects confer resistance to Streptococcus mutans phage ɸAPCM01 DOI Creative Commons

Lee Wall,

Daniel Wall

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 7, 2025

Abstract Streptococcus mutans is a major cause of dental caries worldwide. Targeted therapeutic strategies to eradicate S. include oral phage rinses. In this study, we investigated how resistance develops in . As model phage, used ɸAPCM01, which known infect serotype e strain. We isolated and sequenced the genomes 15 spontaneous resistant mutants found that 10 had acquired novel CRISPR spacers targeting with total 18 new identified. Additionally, eight strains contained mutations rhamnose-glucose polysaccharide (RGP) biosynthetic genes, three also spacers. Only rgp exhibited defects absorption, supporting role these cell surface glycans as receptor. Mutations rgpF newly identified gene rgpX led severe division impaired biofilm formation, latter shared by rgpD mutant. Thus, confer but impose fitness costs, limiting pathogenic potential. Surprisingly, ɸAPCM01 was capable binding injecting its genome into UA159, c However, UA159 infection due an unknown post-entry defense mechanism. Consequently, has potential both serotypes associated caries. Repositories The sequence DPC6143 deposited at NCBI accession number NZ_CP172847.1.

Language: Английский

Citations

0
Microbiological and molecular aspects of periodontitis pathogenesis: an infection-induced inflammatory condition DOI Creative Commons
Mina Yekani,

Masoumeh Dastgir,

Samaneh Fattahi

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 8, 2025

Periodontitis (PD) is the most common oral infectious disease. The primary etiologic cause of onset and development PD dental plaque, which consists bacterial biofilm domiciled within a complex extracellular mass. In patients, there progressive breakdown periodontal ligament alveolar bone. more advanced stages, tooth loss occurs. progression this chronic inflammatory disease involves interactions among numerous microbial pathogens particularly, bacteria, host’s immune factors, various environmental factors. Due to persistent infection by periodonto-pathogenic an impairment both innate acquired immunity, leading tissue destruction. Chronic inflammation in may be associated with several systemic diseases, including cardiovascular conditions, respiratory issues, diabetes, neurological cancer, adverse pregnancy outcomes. Antibiotic treatment one effective strategies for treating cases, although emergence some resistant strains limit effectiveness antibiotics. review study, we discussed main bacteria PD, interaction response, pathogenesis antibiotic treatment. We also outlined resistance antibiotics these pathogens.

Language: Английский

Citations

0