Sirtuin Proteins and Memory: A Promising Target in Alzheimer’s Disease Therapy? DOI Open Access
Francesca Fernandez, Lyn R. Griffiths, Heidi G. Sutherland

et al.

Nutrients, Journal Year: 2024, Volume and Issue: 16(23), P. 4088 - 4088

Published: Nov. 27, 2024

Sirtuins (SIRTs), nicotine adenine dinucleotide (+)-dependent histone deacetylases, have emerged as critical regulators in many signalling pathways involved a wide range of biological processes. Currently, seven mammalian SIRTs been characterized and are found across number cellular compartments. There has considerable interest the role brain due to their plethora metabolic- age-related diseases, including involvement learning memory function physiological pathophysiological conditions. Although cognitive declines over course healthy ageing, neurological disorders Alzheimer's disease (AD) can be associated with progressive impairments. This review aimed report integrate recent advances understanding dysfunction context AD. We also reviewed use selective and/or natural SIRT activators potential therapeutic agents adjuvants for

Language: Английский

The duality of amyloid-β: its role in normal and Alzheimer’s disease states DOI Creative Commons
Ali Azargoonjahromi

Molecular Brain, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 17, 2024

Abstract Alzheimer’s disease (AD) is a degenerative neurological condition that gradually impairs cognitive abilities, disrupts memory retention, and impedes daily functioning by impacting the cells of brain. A key characteristic AD accumulation amyloid-beta (Aβ) plaques, which play pivotal roles in progression. These plaques initiate cascade events including neuroinflammation, synaptic dysfunction, tau pathology, oxidative stress, impaired protein clearance, mitochondrial disrupted calcium homeostasis. Aβ also closely associated with other hallmark features AD, underscoring its significance. generated through cleavage amyloid precursor (APP) plays dual role depending on processing pathway. The non-amyloidogenic pathway reduces production has neuroprotective anti-inflammatory effects, whereas amyloidogenic leads to peptides, Aβ40 Aβ42, contribute neurodegeneration toxic effects AD. Understanding multifaceted Aβ, particularly crucial for developing effective therapeutic strategies target metabolism, aggregation, clearance aim mitigating detrimental consequences disease. This review aims explore mechanisms functions under normal abnormal conditions, examining both beneficial effects.

Language: Английский

Citations

18
Polyphenols, Alkaloids, and Terpenoids Against Neurodegeneration: Evaluating the Neuroprotective Effects of Phytocompounds Through a Comprehensive Review of the Current Evidence DOI Creative Commons

Enzo Pereira de Lima,

Lucas Fornari Laurindo,

Vitor Cavallari Strozze Catharin

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(2), P. 124 - 124

Published: Feb. 13, 2025

Neurodegenerative diseases comprise a group of chronic, usually age-related, disorders characterized by progressive neuronal loss, deformation structure, or loss function, leading to substantially reduced quality life. They remain significant focus scientific and clinical interest due their increasing medical social importance. Most neurodegenerative present intracellular protein aggregation extracellular deposition (plaques), such as α-synuclein in Parkinson's disease amyloid beta (Aβ)/tau aggregates Alzheimer's. Conventional treatments for conditions incur high costs are related the development several adverse effects. In addition, many patients irresponsive them. For these reasons, there is growing tendency find new therapeutic approaches help patients. This review intends investigate some phytocompounds' effects on diseases. These generally increased oxidative stress inflammation, so phytocompounds can prevent treat To achieve our aim provide critical assessment current literature about phytochemicals targeting neurodegeneration, we reviewed reputable databases, including PubMed, EMBASE, COCHRANE, seeking trials that utilized against conditions. A few investigated humans, after screening, 13 were ultimately included following PRISMA guidelines. compounds include polyphenols (flavonoids luteolin quercetin, phenolic acids rosmarinic acid, ferulic caffeic other like resveratrol), alkaloids (such berberine, huperzine A, caffeine), terpenoids ginkgolides limonene). The gathered evidence underscores caffeine, ginkgolides, primarily anti-inflammatory, antioxidant, neuroprotective, counteracting neuroinflammation, oxidation, synaptic dysfunctions, which crucial aspects intervention various conditions, Alzheimer's dementias, depression, neuropsychiatric disorders. summary, they show use improvements cognition, memory, disinhibition, irritability/lability, aberrant behavior, hallucinations, mood

Language: Английский

Citations

5
Synaptic plasticity and neuroprotection: The molecular impact of flavonoids on neurodegenerative disease progression DOI

Spandana Rajendra Kopalli,

Tapan Behl,

Ashishkumar Kyada

et al.

Neuroscience, Journal Year: 2025, Volume and Issue: 569, P. 161 - 183

Published: Feb. 7, 2025

Language: Английский

Citations

1
Design, Synthesis, and Invitro Pharmacological Evaluation of Novel Resveratrol Surrogate Molecules against Alzheimer's Disease DOI
Arunkumar Subramanian,

Tamilanban Thamaraikani,

Vinoth Kumarasamy

et al.

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: 21(9)

Published: June 20, 2024

Abstract A series of resveratrol surrogate molecules were designed, synthesized and biologically evaluated for inhibition acetylcholinesterase (AChE) butyrylcholinesterase (BChE) along with anti‐oxidant activity as potential novel multifunctional agents against Alzheimer's disease (AD). Six compounds by reacting (E)‐4‐(3,5‐Dimethoxystyryl) aniline benzaldehyde some selected derivatives in the presence ethanol a few drops glacial acetic acid which followed general scheme involved formation Schiff bases. The spectral analysis data including FT‐IR, 1 H‐NMR, 13 C‐NMR, Mass spectroscopy results found to be good agreement newly (Resveratrol Surrogate Molecules 1–6). their dual cholinesterase inhibitory activities, cytotoxic effect, potential. showed that compound RSM5 potent AChE BChE. In, addition cytotoxicity is less within desirable limit indicating safety RSM5. Also, it possesses substantial qualifies an anti‐AD agent. Taken together, these findings demonstrate molecule had most properties could promising lead future development drugs treatments.

Language: Английский

Citations

5
Safety Assessment of Resveratrol Surrogate Molecule 5 (RSM5): Acute and Sub-acute Oral Toxicity Studies in BALB/c Mice DOI Creative Commons
Arunkumar Subramanian,

T. Tamilanban,

Amar Daud Iskandar Abdullah

et al.

Toxicology Reports, Journal Year: 2025, Volume and Issue: 14, P. 101956 - 101956

Published: Feb. 14, 2025

Language: Английский

Citations

0
Anti-Neuroinflammatory Eremophilane Sesquiterpenoids from Marine-Derived Fungus Phoma sp. DXH009 DOI Creative Commons
Guanyu Yang, Mengfan Qin,

Mingbin Chen

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(3), P. 94 - 94

Published: Feb. 20, 2025

Three new eremophilane sesquiterpenoids (1–3), together with six known analogues, were isolated from the marine-derived fungus Phoma sp. DXH009. Their structures elucidated through detailed NMR and MS spectroscopic analysis, absolute configurations of 1–4 determined by conformational analysis quantum chemical TDDFT-ECD calculation. anti-neuroinflammatory activities evaluated using lipopolysaccharide (LPS)-induced BV2 microglial cells. The results indicated that compound 5 (dihydrosporogen AO-1) exhibited significant inhibitory effects on production nitric oxide (NO) levels (EC50 = 3.11 μM) less cytotoxicity, leading to a reversal effect in inducing microphage polarization LPS-treated These correlated suppressions canonical NF-κB pathway as well expression key neuroinflammatory markers, including COX2, TNF-α, IL-6, IL-1β. Correspondingly, treating LPS-induced mice efficiently ameliorated neuroinflammation tissues cortex hippocampus. findings suggest sesquiterpenoid could be potential candidate for development drugs.

Language: Английский

Citations

0
Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment DOI
Ali Azargoonjahromi

Brain Imaging and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Natural products in neurodegenerative diseases: recent advances and future outlook DOI Creative Commons

Lutfun Nahar,

Rawiwan Charoensup,

Kulyash Kalieva

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: March 19, 2025

Neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Huntington’s are on the rise pose significant challenges due to lack of effective treatments. This review critically examines neuroprotective effects various natural products derived from plants, marine organisms, fungi. Natural have long been used in traditional medicine gaining attention modern drug discovery for their unique properties. The explains how these can protect neurons by influencing key biological pathways involved neurodegeneration. It discusses mechanisms including antioxidant effects, anti-inflammatory actions, modulation cellular signalling, support mitochondrial function. A systematic literature search was conducted minimize bias ensure rigorous study selection. Preclinical studies using animal models cell cultures show that secondary metabolites like polyphenols, alkaloids, terpenoids significantly reduce neuronal damage. Some clinical trials shown promising results. However, bioavailability, standardization, dosage must be addressed translate findings into practice. also evaluates potential synergy combining with conventional treatments, offering a complementary therapeutic approach. represent avenue developing innovative treatments neurodegenerative diseases. highlights research gaps proposes future directions. Future should focus overcoming existing refining improve efficacy safety settings. application knowledge has enhance quality life individuals affected

Language: Английский

Citations

0
Mitophagy in Alzheimer's disease and other metabolic disorders: a focus on mitochondrial-targeted therapeutics DOI

Shadt Skawratananond,

Daniel X Xiong,

Charlie Zhang

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102732 - 102732

Published: March 1, 2025

Language: Английский

Citations

0
Clinical Insights on Caloric Restriction Mimetics for Mitigating Brain Aging and Related Neurodegeneration DOI Creative Commons

Anchal Trisal,

Abhishek Kumar Singh

Cellular and Molecular Neurobiology, Journal Year: 2024, Volume and Issue: 44(1)

Published: Oct. 16, 2024

Aging, an inevitable physiological process leading to a progressive decline in bodily functions, has been abundantly researched domain with studies attempting slow it down and reduce its debilitating effects. Investigations into the cellular molecular pathways associated aging have allowed formulation of therapeutic strategies. Of these, caloric restriction (CR) implicated for role promoting healthy by modulating key targets like Insulin/IGF-1, mTOR, sirtuins. However, CR requires dedication commitment strict regimen which poses difficulty maintaining consistency. To maneuver around cumbersome diets, Caloric Restriction Mimetics (CRMs) emerged as promising alternatives mimicking beneficial effects CR. This review elucidates foundations enabling CRMs rapamycin, metformin, resveratrol, spermidine, many more function suitable anti-aging molecules. Moreover, explores clinical trials (retrieved from clinicaltrials.gov database) aimed at demonstrating efficacy effective candidates against age-related neurodegenerative diseases such Alzheimer's disease Parkinson's disease.

Language: Английский

Citations

2