Cognitive implications of white matter microstructural changes in individuals with low heart rate variability: a NODDI study DOI Creative Commons
Shaofan Jiang, Yingzhe Cheng, Ling Luo

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: May 9, 2025

Objective This study aimed to investigated the microstructural integrity of WM and relationship with cognitive domains cognition-related plasma biomarkers in low heart rate variability (HRV). Methods Our recruited 44 high HRV (Grouping by median HF). Diffusion Magnetic resonance imaging (MRI) was utilized for calculation neurite orientation dispersion density (NODDI) parameters, tract-based spatial statistics (TBSS) were employed explore differential clusters. The fibers covered these clusters defined as regions interest (ROI) extraction NODDI parameter values analysis their correlation biomarkers. Results TBSS unveiled specific cerebral exhibiting disparities within group group. These differences evident fractional isotropy (FISO; p < 0.05). extracted from ROIs ( 0.05) mainly manifested anterior brain corpus callosum. Further showed that abnormal white matter (WM) significant correlations CDR, RCFT-I, RCFT-D, attention, memory, language, varying degrees. Conclusion Patients exhibit distinctive patterns changes revealed FISO which indicate a decline integrity, between HRV-related worse performance may be attributed damage frontal-corpus callosum pathways.

Language: Английский

Protective Effects of Bifidobacterium Breve MCC1274 as a Novel Therapy for Alzheimer’s Disease DOI Open Access
Mona Abdelhamid, Scott Counts, Chunyu Zhou

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(3), P. 558 - 558

Published: Jan. 31, 2025

Alzheimer’s disease (AD) is the most common form of dementia and characterized by memory impairment that significantly interferes with daily life. Therapeutic options for AD substantively modify progression remain a critical unmet need. In this regard, gut microbiota crucial in maintaining human health regulating metabolism immune responses, increasing evidence suggests probiotics, particularly beneficial bacteria, can enhance cognitive functions. Recent studies have highlighted positive effects Bifidobacterium breve MCC1274 (B. MCC1274) on individuals mild (MCI) schizophrenia. Additionally, oral supplementation B. has been shown to effectively prevent decline AppNL–G–F mice. relation pathology, found reduce amyloid-β (Aβ) accumulation tau phosphorylation both wild-type (WT) It also decreases microglial activation increases levels synaptic proteins. review, we examine AD, exploring potential mechanisms action how probiotic strain may aid preventing or treating disease. Furthermore, discuss broader implications improving overall host provide insights into future research directions promising therapy.

Language: Английский

Citations

2
Epigenetic Mechanisms Underlying Sex Differences in Neurodegenerative Diseases DOI Creative Commons
Andrea Stoccoro

Biology, Journal Year: 2025, Volume and Issue: 14(1), P. 98 - 98

Published: Jan. 19, 2025

Neurodegenerative diseases are characterized by profound differences between females and males in terms of incidence, clinical presentation, disease progression. Furthermore, there is evidence suggesting that sensitivity to medical treatments may exist the two sexes. Although role sex hormones chromosomes driving differential susceptibility these well-established, molecular alterations underlying remain poorly understood. Epigenetic mechanisms, including DNA methylation, histone tail modifications, activity non-coding RNAs, strongly implicated pathogenesis neurodegenerative diseases. While it known epigenetic mechanisms play a crucial sexual differentiation distinct patterns characterize males, sex-specific have been largely overlooked studies aiming identify associated with This review aims provide an overview processes central nervous system, main three diseases, Alzheimer’s disease, Parkinson’s amyotrophic lateral sclerosis. Understanding sex-related essential for developing personalized interventions account unique landscapes each sex.

Language: Английский

Citations

1
Role of Tau and Amyloid-beta in autophagy gene dysregulation through oxidative stress DOI

Mehrnaz Haghi,

Raheleh Masoudi, Fatemeh Ataellahi

et al.

Tissue and Cell, Journal Year: 2025, Volume and Issue: unknown, P. 102765 - 102765

Published: Jan. 1, 2025

Language: Английский

Citations

1
Psychedelics in neuroinflammation: Mechanisms and therapeutic potential DOI

Júnia L. de Deus,

Juliana Marino Maia, Renato Nery Soriano

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111278 - 111278

Published: Jan. 1, 2025

Language: Английский

Citations

1
The potential link between the development of Alzheimer’s disease and osteoporosis DOI Creative Commons

Fariha Nasme,

Jyotirmaya Behera,

Prisha Tyagi

et al.

Biogerontology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Jan. 20, 2025

Language: Английский

Citations

0
Changes in the pH value of the human brain in Alzheimer’s disease pathology correlated with CD68-positive microglia: a community-based autopsy study in Beijing, China DOI Creative Commons
Xue Wang,

Xiangqi Shao,

Liang Yu

et al.

Molecular Brain, Journal Year: 2025, Volume and Issue: 18(1)

Published: Feb. 10, 2025

Abstract The microenvironment of the central nervous system is highly complex and plays a crucial role in maintaining function neurons, which influences Alzheimer’s disease (AD) progression. pH value brain critical aspect regulating various physiological processes. However, specific mechanisms this mechanism are not yet fully understood. To better understand relationship between AD, we analyzed frontal lobe AD pathology scores postmortem samples from 368 donors National Human Brain Bank for Development Function, 96 whom were diagnosed with pathology. Analysis revealed significant decrease patients, was strongly correlated β-amyloid plaques phosphorylated tau proteins. Here, elucidated differential protein expression level CD68-positive microglia control groups (t = 3.198, df 20, P 0.0045), its negatively (F 26.93, p 0.0006). Our findings that increased activation disrupted lysosomal homeostasis pathological tissue individuals may lead to pH.

Language: Английский

Citations

0
Plasma tryptophan levels are linked to hippocampal integrity and cognitive function in individuals with mild cognitive impairment DOI
Ali Azargoonjahromi

Brain Imaging and Behavior, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Language: Английский

Citations

0
Exploring Alzheimer's Disease Treatment: Established Therapies and Novel Strategies for Future Care DOI
Urvashi Soni, Kuldeep Singh, Divya Jain

et al.

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177520 - 177520

Published: March 1, 2025

Language: Английский

Citations

0
Strategic delivery of omega-3 fatty acids for modulating inflammatory neurodegenerative diseases DOI Creative Commons
Yixin Chen,

Roni Touboul,

Yao Chen

et al.

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: March 17, 2025

Early-life inflammatory events like infections and injuries may predispose the brain to Alzheimer's disease (AD) by disrupting neurodevelopment raising vulnerability. The association between early neuroinflammation subsequent neurodegeneration leading dementia remains unclear. We hypothesize that omega-3 (n-3) fatty acids (FA), especially eicosapentaenoic acid (EPA) docosahexaenoic (DHA), positively regulate neuro-immune cells, preserving their cell membrane structure metabolic homeostasis. Our study examined whether strategic delivery of n-3 FA via injectable triglycerides (TG) can influence microglial lipid metabolism prevent or delay AD progression. characterized treatment effects on modulating homeostasis in microglia during critical window development. preliminary studies determining indicate perinatal bolus TG injections suppressed activation gliosis-associated markers young mice predisposed (5xFAD) yielded sustained regulatory expression molecules, such as interleukin-6 (Il6) tumor necrosis factor-alpha (Tnfα), adult brains. A significant increase high-frequency ultrasonic vocalizations (USV) was observed P6 5xFAD received compared vehicle control, implicating enhanced active communication patterns. Improvement behavior deficits n-3-treated mice. Perinatal modified composition offspring, increasing key species, phospholipids (PL) lysophospholipids (lysoPL). Pro-inflammatory sphingolipids associated with neurodegeneration, including lactosylceramide, were significantly lower treated than those saline-treated establishes a proof principle for targeting immune mitigate pathogenesis, paving way future research into treatments related central nervous system (CNS) disorders.

Language: Английский

Citations

0
Post-traumatic stress disorder, metabolic syndrome, diabetic distress, and vitamin B1/benfotiamine DOI Open Access
Victoria Serhiyenko, O.М. Chemerys, V.І. Pankiv

et al.

INTERNATIONAL NEUROLOGICAL JOURNAL, Journal Year: 2025, Volume and Issue: 21(1), P. 96 - 107

Published: March 20, 2025

A person with post-traumatic stress disorder (PTSD) is more likely to develop metabolic syndrome (MetS), depression, and diabetic distress. It also raises the risk of cardiometabolic neurodegenerative diseases (NDD). At same time, type 2 diabetes mellitus MetS can cause development core neurosis-like psychiatric symptoms characteristic PTSD. Chronic associated cardiovascular diseases, diabetes, NDD. More people think that mitochondrial dysfunction, peripheral/central chronic low-grade inflammation (CLGI), oxidative are main causes these diseases. Pathophysiological processes link them together. To make things better for patients, interventions aim control CLGI may be better, following ideas precision medicine. Deficiency certain biofactors, in particular, vitamin B1, an increased MetS, Targeted effects on CLGI, stress, metabolism disorders suggest use antioxidants, particularly B1/benfotiamine (BFT), have a positive effect not only course comorbid but manifestations Exogenous or BFT, corrects thiamine status disorders. BFT exhibits potent animal models NDD, stress-induced anxiety, aggression, depression. Thus, considered potentially safe cost-effective drug treatment many central nervous system Despite its aspects, therapeutic potential remains limited, as beneficial require high doses over long period time. Dibenzoylthiamine, lipophilic form has been shown anti-inflammatory antioxidant at much lower than both vitro vivo. However, preclinical clinical studies needed sure viability dibenzoylthiamine. This review pays extra attention analysis features biological role mechanism action, especially impact glucose function, state neuroinflammation, how dibenzoylthiamine protect neurons. We conducted search Scopus, Science Direct (from Elsevier), PubMed, MEDLINE databases. The keywords used were “thiamine”, “benfotiamine”, “dibenzoylthiamine”, “post-traumatic disorder”, “metabolic syndrome”, “diabetic distress”, “diabetes mellitus”. manual bibliography publications pinpoint research results eluded online search.

Language: Английский

Citations

0