Fluids and Barriers of the CNS, Journal Year: 2023, Volume and Issue: 20(1)
Published: April 20, 2023
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(12), P. 4667 - 4687
Published: Aug. 14, 2023
The blood–brain barrier (BBB) impairment plays a crucial role in the pathological processes of aging-accompanied neurological diseases (AAND). Meanwhile, circadian rhythms disruption and gut microbiota dysbiosis are associated with increased morbidity accelerated aging population. Importantly, also known to induce generation toxic metabolites pro-inflammatory cytokines, resulting BBB integrity. Collectively, this provides new perspective for exploring relationship among rhythms, microbes, diseases. In review, we focus on recent advances interplay between rhythm disturbances dysbiosis, their potential roles that occurs AAND. Based existing literature, discuss propose mechanisms underlying damage induced by dysregulated microbiota, which would serve as basis developing interventions protect population through targeting exploiting its links treating
Language: Английский
Citations
22
Journal of Neurochemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 26, 2024
Abstract Post‐stroke neuroinflammation is pivotal in brain repair, yet persistent inflammation can aggravate ischemic damage and hamper recovery. Following stroke, specific molecules released from cells attract activate central peripheral immune cells. These subsequently release diverse inflammatory within the brain, initiating a sequence of events, including activation transcription factors different cell types that modulate gene expression influence outcomes; interactive action various noncoding RNAs (ncRNAs) to regulate multiple biological processes inflammation, epitranscriptomic RNA modification controls processing, stability, translation; epigenetic changes DNA methylation, hydroxymethylation, histone modifications crucial managing genic response stroke. Interactions among these events further affect post‐stroke shape depth functional outcomes. We highlighted aspects this review postulate deciphering mechanisms for identifying therapeutic targets alleviate dysfunction enhance
Language: Английский
Citations
5
Genes, Journal Year: 2025, Volume and Issue: 16(1), P. 59 - 59
Published: Jan. 6, 2025
Recent advances in stroke genetics have substantially enhanced our understanding of the complex genetic architecture underlying cerebral infarction and other subtypes. As knowledge this field expands, healthcare providers must remain informed about these latest developments. This review aims to provide a comprehensive overview recent genetics, with focus on infarction, discuss their potential impact patient care future research directions. We reviewed literature focusing discussed Key developments include identification monogenic syndromes, such as autosomal dominant arteriopathy subcortical infarcts leukoencephalopathy, recessive leukoencephalopathy caused by mutations NOTCH3 HTRA1 genes, respectively. In addition, role RNF213 moyamoya disease cerebrovascular disorders, particularly East Asian populations, has been elucidated. The development polygenic risk scores for assessing predisposition demonstrated improve prediction beyond traditional factors. Genetic studies also elucidated distinct subtypes, including large artery atherosclerosis, small vessel disease, cardioembolic stroke. Furthermore, investigation epigenetic modifications influencing its outcomes revealed new avenues, while advancements pharmacogenomics highlight personalized treatment based individual profiles. These discoveries important clinical implications, improved stratification, targeted prevention strategies, novel therapeutic approaches.
Language: Английский
Citations
0
Brain Research, Journal Year: 2025, Volume and Issue: unknown, P. 149528 - 149528
Published: Feb. 1, 2025
Language: Английский
Citations
0
Steroids, Journal Year: 2025, Volume and Issue: 216, P. 109584 - 109584
Published: Feb. 28, 2025
Language: Английский
Citations
0
Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)
Published: March 5, 2025
Language: Английский
Citations
0
Advances in Biomarker Sciences and Technology, Journal Year: 2024, Volume and Issue: 6, P. 120 - 137
Published: Jan. 1, 2024
A stroke is a medical emergency characterized by the sudden interruption of blood flow to brain, leading cell death from oxygen deprivation. As cause mortality and long-term disability worldwide, strokes present growing socioeconomic challenge, exacerbated demographic shifts an increasing incidence in younger populations. Analyzing post-stroke conditions essential for predicting recovery trajectories guiding personalized treatments. The process crucial mitigating cognitive deficits improving quality life survivors their families. Epigenetic mechanisms are emerging as key influencers, with four significant modulators—miRNAs, lncRNAs, DNA methylation, histone modifications—being identified central modulating neuronal repair regeneration. However, this lack knowledge how major epigenetic signatures affect recovery. paper systematically reviews capacity miRNAs fine-tune neuroprotective responses broader regulatory functions lncRNAs. Additionally, we examine methylation patterns modifications correlate outcomes, presenting case precise therapies. In review, highlight that these modulators offer promising therapeutic targets enhancing provide novel insights into pathology treatment. We also comparative analysis challenges future perspectives each one. review sets forth trajectory research, underscoring development epigenetic-based therapeutics groundbreaking approach enhance neurorehabilitation improve patient prognoses.
Language: Английский
Citations
2
Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 253, P. 155085 - 155085
Published: Jan. 1, 2024
Language: Английский
Citations
1
Gene, Journal Year: 2023, Volume and Issue: 887, P. 147788 - 147788
Published: Sept. 10, 2023
Language: Английский
Citations
3
Journal of Stroke and Cerebrovascular Diseases, Journal Year: 2024, Volume and Issue: 33(5), P. 107585 - 107585
Published: Jan. 21, 2024
Language: Английский
Citations
0