Toxicological Sciences,
Journal Year:
2024,
Volume and Issue:
199(1), P. 149 - 159
Published: Feb. 17, 2024
Abstract
Large-scale
production
and
waste
of
plastic
materials
have
resulted
in
widespread
environmental
contamination
by
the
breakdown
product
bulk
to
micro-
nanoplastics
(MNPs).
The
small
size
these
particles
enables
their
suspension
air,
making
pulmonary
exposure
inevitable.
Previous
work
has
demonstrated
that
xenobiotic
nanoparticles
during
gestation
leads
maternal
vascular
impairments,
as
well
cardiovascular
dysfunction
within
fetus.
Few
studies
assessed
toxicological
consequences
nanoplastic
(NP)
exposure;
therefore,
objective
this
study
was
assess
fetal
health
after
a
single
polystyrene
NP
late
gestation.
We
hypothesized
acute
would
impair
function.
Pregnant
rats
were
exposed
nanopolystyrene
on
gestational
day
19
via
intratracheal
instillation.
24
h
later,
outcomes
evaluated.
Cardiovascular
function
dams
using
myography
ex
vivo
fetuses
measured
ultrasound.
Both
placental
weight
reduced
nanopolystyrene.
Increased
heart
aorta
evident
dams.
Maternal
led
radial
artery
uterus,
resistance
vessel
controls
blood
flow
fetoplacental
compartment.
Function
heart,
aorta,
umbilical
dysregulated.
Taken
together,
data
suggest
NPs
negatively
impacts
health,
highlighting
concern
MNPs
pregnancy
development.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(3), P. 2370 - 2383
Published: Jan. 8, 2024
Nanoplastics
(NPs)
pervade
daily
life,
posing
serious
threats
to
marine
ecosystems.
Despite
the
crucial
role
that
surface
charge
plays
in
NP
effects,
there
is
a
substantial
gap
our
understanding
of
how
influences
toxicity.
Herein,
by
exposing
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
283, P. 116818 - 116818
Published: July 30, 2024
Microplastics
(MPs)
have
been
detected
in
various
human
tissues.
However,
whether
MPs
can
accumulate
within
tumors
and
how
they
affect
the
tumor
immune
microenvironment
(TIME)
therapeutic
responses
remains
unclear.
This
study
aimed
to
determine
presence
of
their
potential
effects
on
TIME.
Sixty-one
samples
were
collected
for
analysis.
The
was
qualitatively
quantitatively
assessed
using
pyrolysis-gas
chromatography-mass
spectrometry.
26
examined.
Three
types
identified:
polystyrene,
polyvinyl
chloride,
polyethylene.
In
lung,
gastric,
colorectal,
cervical
tumors,
MP
detection
rates
80
%,
40
50
17
%
(7.1-545.9
ng/g),
respectively.
70
pancreatic
(18.4-427.1
ng/g)
but
not
esophageal
tumors.
cancer,
MP-infiltrated
TIME
exhibited
a
reduction
CD8
European Heart Journal,
Journal Year:
2024,
Volume and Issue:
45(38), P. 4099 - 4110
Published: Sept. 6, 2024
Abstract
Emerging
evidence
indicates
that
chemical
exposures
in
the
environment
are
overlooked
drivers
of
cardiovascular
diseases
(CVD).
Recent
suggests
micro-
and
nanoplastic
(MNP)
particles
derived
largely
from
or
mechanical
degradation
plastics
might
represent
a
novel
CVD
risk
factor.
Experimental
data
preclinical
models
suggest
MNPs
can
foster
oxidative
stress,
platelet
aggregation,
cell
senescence,
inflammatory
responses
endothelial
immune
cells
while
promoting
range
metabolic
alterations
lead
to
disease
premature
death.
In
humans,
various
plastics,
including
polyethylene
polyvinylchloride,
have
been
detected
atherosclerotic
plaques
other
tissues,
pericardia,
epicardial
adipose
pericardial
myocardia,
left
atrial
appendages.
measurable
levels
within
thrombi
seem
accumulate
preferentially
areas
vascular
lesions.
Their
presence
carotid
is
associated
with
subsequent
increased
incidence
events.
To
further
investigate
possible
causal
role
CVD,
future
studies
should
focus
on
large,
prospective
cohorts
assessing
exposure
individuals
plastic-related
pollution,
routes
absorption,
existence
putative
safety
limit,
correspondence
between
accumulation
timing
development,
pathophysiological
mechanisms
instigated
by
pertinent
concentrations
MNPs.
Data
such
would
allow
design
preventive,
even
therapeutic,
strategies.
Meanwhile,
existing
reducing
plastic
production
use
will
produce
benefits
for
human
health.
This
goal
could
be
achieved
through
UN
Global
Plastics
Treaty
currently
negotiation.
Toxicological Sciences,
Journal Year:
2024,
Volume and Issue:
199(1), P. 149 - 159
Published: Feb. 17, 2024
Abstract
Large-scale
production
and
waste
of
plastic
materials
have
resulted
in
widespread
environmental
contamination
by
the
breakdown
product
bulk
to
micro-
nanoplastics
(MNPs).
The
small
size
these
particles
enables
their
suspension
air,
making
pulmonary
exposure
inevitable.
Previous
work
has
demonstrated
that
xenobiotic
nanoparticles
during
gestation
leads
maternal
vascular
impairments,
as
well
cardiovascular
dysfunction
within
fetus.
Few
studies
assessed
toxicological
consequences
nanoplastic
(NP)
exposure;
therefore,
objective
this
study
was
assess
fetal
health
after
a
single
polystyrene
NP
late
gestation.
We
hypothesized
acute
would
impair
function.
Pregnant
rats
were
exposed
nanopolystyrene
on
gestational
day
19
via
intratracheal
instillation.
24
h
later,
outcomes
evaluated.
Cardiovascular
function
dams
using
myography
ex
vivo
fetuses
measured
ultrasound.
Both
placental
weight
reduced
nanopolystyrene.
Increased
heart
aorta
evident
dams.
Maternal
led
radial
artery
uterus,
resistance
vessel
controls
blood
flow
fetoplacental
compartment.
Function
heart,
aorta,
umbilical
dysregulated.
Taken
together,
data
suggest
NPs
negatively
impacts
health,
highlighting
concern
MNPs
pregnancy
development.
