The Medical and Ecological Problems,
Journal Year:
2024,
Volume and Issue:
28(3), P. 42 - 60
Published: Dec. 30, 2024
Airborne
microplastic
(NP)
and
nanoplastic
(MP)
pollution
has
emerged
as
a
pressing
environmental
concern
with
significant
implications
for
human
health.
While
MPs
are
present
both
indoors
outdoors,
indoor
concentrations
generally
higher
due
to
the
abrasion
of
household
materials,
furniture,
other
domestic
sources.
NPs,
when
inhaled,
accumulate
in
various
lung
regions,
exerting
toxic
effects
potentially
leading
respiratory
diseases.
This
systematic
review,
conducted
according
PRISMA
guidelines,
evaluates
recent
experimental
studies
on
pathogenic
impact
nanomicroplastics
(NMPs)
tissues
using
vivo
vitro
models.
The
review
included
10
analyzing
MP
accumulation
90
examining
pathogenetic
mechanisms
exposure.
Research
data
indicates
predominance
polymeric
fibers
such
polypropylene,
polyethylene
terephthalate,
polytetrafluoroethylene,
accounting
nearly
half
structures.
NMPs
exhibit
size-
composition-dependent
accumulation,
smaller
positively
charged
particles
showing
translocation
potential
systemic
circulation
organs.
highlights
synergistic
heavy
metals
pollutants,
interaction
pulmonary
surfactant,
role
exacerbating
Current
analysis
underscores
growing
interest
NMP-related
health
risks
identifies
knowledge
gaps,
including
need
standardization
NMP
toxicity
testing
further
exploration
biological
systems.
findings
emphasize
importance
mitigating
exposure
safeguard
pave
way
future
research
long-term
impacts
airborne
Cancers,
Journal Year:
2024,
Volume and Issue:
16(21), P. 3703 - 3703
Published: Nov. 1, 2024
Humans
cannot
avoid
plastic
exposure
due
to
its
ubiquitous
presence
in
the
natural
environment.
The
waste
generated
is
poorly
biodegradable
and
exists
form
of
MPs,
which
can
enter
human
body
primarily
through
digestive
tract,
respiratory
or
damaged
skin
accumulate
various
tissues
by
crossing
biological
membrane
barriers.
There
an
increasing
amount
research
on
health
effects
MPs.
Most
literature
reports
focus
impact
plastics
respiratory,
digestive,
reproductive,
hormonal,
nervous,
immune
systems,
as
well
metabolic
MPs
accumulation
leading
epidemics
obesity,
diabetes,
hypertension,
non-alcoholic
fatty
liver
disease.
xenobiotics,
undergo
ADMET
processes
body,
i.e.,
absorption,
distribution,
metabolism,
excretion,
are
not
fully
understood.
Of
particular
concern
carcinogenic
chemicals
added
during
manufacturing
adsorbed
from
environment,
such
chlorinated
paraffins,
phthalates,
phenols,
bisphenols,
be
released
when
absorbed
body.
continuous
increase
NMP
has
accelerated
SARS-CoV-2
pandemic
there
was
a
need
use
single-use
products
daily
life.
Therefore,
urgent
diagnose
problems
related
MP
detection.
Reproductive Biology and Endocrinology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Nov. 11, 2024
The
female
reproductive
system
can
face
serious
disorders
and
show
abnormalities
under
the
influence
of
environmental
pollutants.
Microplastics
(MPs)
nanoplastics
(NPs)
as
emerging
pollutants,
by
affecting
different
components
this
system,
may
make
fertility
a
challenge.
Animal
studies
have
demonstrated
that
exposure
to
these
substances
weakens
function
ovaries
causes
decrease
in
ovarian
reserve
capacity.
Also,
continuous
micro/nano
plastics
(MNPs)
leads
increased
levels
reactive
oxygen
species,
induction
oxidative
stress,
inflammatory
responses,
apoptosis
granulosa
cells,
reduction
number
follicles.
Furthermore,
interfering
with
hypothalamic-pituitary-ovarian
axis,
particles
disturb
normal
androgens
endocrine
balance
delay
growth
gonads.
Exposure
MNPs
accelerate
carcinogenesis
humans
animal
models.
determined
accumulate
placenta,
causing
metabolic
changes,
disrupting
development
fetus,
endangering
health
future
generations.
In
humans,
presence
micro/nanoplastics
placenta
tissue,
infant
feces,
breast
milk
has
been
reported.
These
directly
affect
mother
increasing
risk
premature
birth
other
pregnancy
complications.
This
review
aims
outline
hazardous
effects
on
fetal
discuss
results
experiments
human
research
focusing
cellular
molecular
pathways.
Humans
are
constantly
exposed
to
micro-
and
nanosized
plastics
(MNPs);
however,
there
is
still
limited
understanding
of
their
fate
within
the
body,
partially
due
limitations
with
current
analytical
techniques.
The
study
assessed
appropriateness
pyrolysis–gas
chromatography–mass
spectrometry
(Py-GC-MS)
analysis
for
quantification
a
range
polymers
in
human
blood.
An
extraction
protocol
that
reduced
matrix
interferences
(false
positives)
polyethylene
(PE)
polyvinyl
chloride
(PVC)
was
developed
validated.
Extraction
recoveries
ranged
7–109%,
although
surface-modified
polystyrene
(carboxylated)
increased
nanoparticle
from
17
52%.
Realistic
detection
limits
were
calculated
each
polymer,
accounting
suppression
recovery.
These
up
20
times
higher
than
nominal
Milli-Q
water.
Finally,
method
tested
pilot
Australian
population.
PE
but
present,
no
other
above
limits.
It
concluded
Py-GC-MS
currently
not
suitable
PVC
biological
matrices
presence
nonspecific
pyrolysis
products.
Furthermore,
while
it
plausible
detect
some
blood,
estimated
exposure
concentrations
needed
approaching
technique.
