Black Sea Journal of Engineering and Science,
Journal Year:
2023,
Volume and Issue:
6(4), P. 540 - 549
Published: Sept. 29, 2023
Analgesics
are
one
of
the
most
widely
used
drug
groups
in
world.
Since
genotoxic
and
carcinogenic
effects
some
analgesic
drugs
have
been
detected,
studies
investigating
these
increased.
In
this
study,
Tenoxicam
Piroxicam
were
investigated
vitro
human
peripheral
lymphocytes
by
chromosomal
aberrations
(CAs)
micronucleus
(MN)
assays.
addition,
mitotic
index
(MI)
nuclear
division
(NDI)
values
also
determined.
As
a
result,
no
difference
abnormalities
was
observed
both
24
48
hours
treatment.
Micronucleus
frequency
increased
at
three
highest
concentrations
(0.94,
1.88
3.75
µg/mL)
compared
to
control.
significantly
decreased
MI
control
solvent
µg/mL
all
exposure
times.
showed
statistically
significant
increase
concentration
(10
μg/mL)
h
CA
On
other
hand,
effect
48-hour
It
concluded
that
tenoxicam
did
not
cause
toxic
any
except
MN
assay
results.
Mitotic
1.25,
2.5,
5
10
μg/mL.
Nuclear
results
change
for
agents.
conclusion,
agents
found
be
only
high
weak.
This
study
is
pioneering
as
there
previous
Tenoxicam.
These
need
supported
different
cell
vivo
Nanotoxicology,
Journal Year:
2023,
Volume and Issue:
17(6-7), P. 497 - 510
Published: Aug. 9, 2023
As
one
representative
of
nanometal
oxides,
titanium
dioxide
nanoparticles
(TiO2-NPs)
have
been
widely
used,
particularly
in
the
food
industry.
The
genotoxicity
TiO2-NPs
has
attracted
great
attention
over
years.
This
study
was
undertaken
to
investigate
chromosome
and
DNA
damage
effects
(0,
50,
150,
500
mg/kg
BW)
using
rodent
models.
After
a
comprehensive
characterization,
we
conducted
standard
battery
vivo
tests,
including
chromosomal
aberration
test
(CA),
micronucleus
(MN)
test,
comet
test.
results
all
these
tests
were
negative.
There
no
structural
or
numerical
abnormalities
mice
bone
marrow
cells,
increase
frequency
micronucleated
polychromatic
erythrocytes
elevation
%
tail
rat
hepatocytes.
indicated
that
did
not
cause
direct
impact
on
DNA.
These
findings
suggested
exhibit
provided
valuable
data
for
risk
assessment
purposes.
Advances in chemical and materials engineering book series,
Journal Year:
2024,
Volume and Issue:
unknown, P. 125 - 150
Published: Oct. 22, 2024
In
this
chapter,
the
authors
present
nanomaterials
for
biomedical
application
as
promising
technology
of
drug
delivery,
biosensors,
and
tissue
engineering.
Nanomaterials
have
revolutionized
field
applications
because
they
provide
sophisticated
solutions
engineering,
biosensing,
administration
through
treating
diagnosing
a
variety
human
ailments,
including
cancer,
heart
disease,
dental
conditions,
disorders
central
peripheral
nervous
systems.
play
crucial
role
in
achieving
sustainable
development
goals
by
offering
innovative
across
various
health
sectors.
author
discussion
attempts
to
indicate
revolutionary
impact
on
research
clinical
practice
an
extensive
recent
developments
problems
areas
applications:
Archives of Toxicology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 24, 2024
Abstract
Emerging
cellulose
nanomaterials
(CNMs)
may
have
commercial
impacts
in
multiple
sectors,
being
their
application
particularly
explored
the
food
sector.
Thus,
potential
adverse
effects
gastrointestinal
tract
should
be
evaluated
before
marketing.
This
work
aimed
to
assess
safety
of
two
CNMs
(CNF–TEMPO
and
CMF–ENZ)
through
investigation
cytotoxicity,
genotoxicity
(comet
micronucleus
assays),
capacity
induce
reactive
oxygen
species
human
intestinal
cells,
mutagenic
effect
using
Hprt
gene
mutation
assay.
Each
toxicity
endpoint
was
analysed
after
cells
exposure
a
concentration-range
each
CNM
or
its
digested
product,
obtained
by
standardized
static
vitro
digestion
method.
The
results
showed
an
absence
cytotoxic
up
highest
concentration
tested
(200
µg/mL
25
µg/mL,
for
non-digested
CNMs,
respectively).
Of
note,
cytotoxicity
control
limited
top
samples
(25
µg/mL)
subsequent
assays.
Application
battery
assays
that
CNF–TEMPO
CMF–ENZ
do
not
mutations
aneugenic/clastogenic
effects.
However,
due
observed
DNA
damage
induction,
genotoxic
cannot
excluded,
even
though
seems
attenuate
effect.
lowest
induced
chromosomal
Caco-2
leading
equivocal
outcome.
Ongoing
research
on
epigenotoxic
these
strengthen
lines
evidence
when
ingested,
paving
way
innovative
industry.
Advances in Clinical Toxicology,
Journal Year:
2023,
Volume and Issue:
8(4), P. 1 - 23
Published: Jan. 1, 2023
This
critical
review
focuses
on
Engineered
nanoparticles
(ENPs)
types,
properties,
toxicities,
applications,
and
future
scopes.
ENPs
are
specially
designed
chemical
substances
or
materials
with
a
particle
size
between
1
100
nm
in
at
least
one
dimension,
while
the
term
nanomaterials
(ENMs)
is
used
collectively
for
nanostructured
materials.
They
can
be
classified
into
different
classes
based
their
shapes,
sizes.
The
groups
include
fullerenes,
metal
NPs,
ceramic
polymeric
NPs.
NPs
possess
unique
physical
properties
due
to
high
surface
area
nanoscale
size.
like
carbon
nanotubes
(CNTs),
quantum
dots
(QDs),
nanocomposites,
metal-oxide
(TiO2,
ZnO,
iron
oxides),
fibrous
(NMs).
Exposure
such
ENP
increases
as
nanotechnology
advances,
though
it
an
emerging
field
wide
range
of
applications
interdisciplinary,
integrated
science
huge
potential.
Aims
present
comprehensive
nanotoxicity
human
health
impact
environment,
aspects
breakthrough
opportunities.
Nanowaste
new
challenging
research
topic
also
highlighted.
NPs’
intensive
use,
persistence,
retention
environment
need
evaluate
nanogenotoxicity
humans
other
organisms.
ENMs
therapeutic
targeted
drug
delivery,
toxicokinetic,
chemistry,
mechanism
cellular
interactions,
effect
chromosomes,
DNA
started
being
studied
by
researchers,
however,
not
fully
understood.
Nano
genotoxicity
assessment
should
done
thoroughly
following
regulatory
guidelines
order
safeguard
from
its
harmful
effects
cancer
reduce
fertility.
ENM
time
traced
keeping
mind
Eco
nanotoxicity,
bioaccumulation,
biomagnification
aquatic
forest
ecosystems.
utilized
knowing
all
useful
characteristics
inventions
care,
treatment,
anti-aging
(longevity),
aeronautics,
illuminating
diodes,
nanofertilizers
Artificial
Intelligence
(AI)-powered
robotics
noble
innovations
use.
Finally,
challenges
nanowaste
management
gaps
opportunities
highlighted
reflect
more
serious
action
advancement
nanoscience
novel
inventions.
Black Sea Journal of Engineering and Science,
Journal Year:
2023,
Volume and Issue:
6(4), P. 540 - 549
Published: Sept. 29, 2023
Analgesics
are
one
of
the
most
widely
used
drug
groups
in
world.
Since
genotoxic
and
carcinogenic
effects
some
analgesic
drugs
have
been
detected,
studies
investigating
these
increased.
In
this
study,
Tenoxicam
Piroxicam
were
investigated
vitro
human
peripheral
lymphocytes
by
chromosomal
aberrations
(CAs)
micronucleus
(MN)
assays.
addition,
mitotic
index
(MI)
nuclear
division
(NDI)
values
also
determined.
As
a
result,
no
difference
abnormalities
was
observed
both
24
48
hours
treatment.
Micronucleus
frequency
increased
at
three
highest
concentrations
(0.94,
1.88
3.75
µg/mL)
compared
to
control.
significantly
decreased
MI
control
solvent
µg/mL
all
exposure
times.
showed
statistically
significant
increase
concentration
(10
μg/mL)
h
CA
On
other
hand,
effect
48-hour
It
concluded
that
tenoxicam
did
not
cause
toxic
any
except
MN
assay
results.
Mitotic
1.25,
2.5,
5
10
μg/mL.
Nuclear
results
change
for
agents.
conclusion,
agents
found
be
only
high
weak.
This
study
is
pioneering
as
there
previous
Tenoxicam.
These
need
supported
different
cell
vivo
