The role of miR-152 in urological tumors: potential biomarkers and therapeutic targets DOI Creative Commons
Xin Li,

Biao Qian,

Xu Chen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Urological malignant tumors pose a significant threat to human health, with high incidence rate each year. Prostate cancer, bladder and renal cell carcinoma are among the most prevalent extensively researched urological malignancies. Despite advancements in research, prognosis for these remains unfavorable due late detection, postoperative recurrence, treatment resistance. A thorough investigation into their pathogenesis is crucial early diagnosis treatment. Recent studies have highlighted close association between microRNAs (miRNAs) cancer progression. miRNAs small non-coding RNAs composed of 19-23 nucleotides that regulate gene expression by binding 3’ untranslated region (3’UTR) target mRNAs, impacting key cellular processes such as proliferation, differentiation, apoptosis, migration. Dysregulation can disrupt oncogenes tumor suppressor genes, contributing development. Among various studied, miR-152 has garnered attention its role Several indicated dysregulation cancers, warranting comprehensive review evidence. This focuses on function prostate carcinoma, elucidating mechanisms progression exploring potential therapeutic biomarker

Language: Английский

Regulation of the HIF switch in human endothelial and cancer cells DOI Creative Commons
Jakub Sławski, Maciej Jaśkiewicz, Anna Barton

et al.

European Journal of Cell Biology, Journal Year: 2024, Volume and Issue: 103(2), P. 151386 - 151386

Published: Jan. 21, 2024

Hypoxia-inducible factors (HIFs) are transcription that reprogram the transcriptome for cells to survive hypoxic insults and oxidative stress. They important during embryonic development utilize glycolysis when oxygen levels extremely low. This metabolic change facilitates normal cell survival as well cancer survival. The key feature in is transition between acute hypoxia chronic hypoxia, this regulated by HIF-1 expression HIF-2/HIF-3 expression. observed many human cancers endothelial referred HIF Switch. Here we discuss mechanisms involved Switch which include mRNA protein of alpha chains HIFs. A major continuing effort field directed towards determining differences tumor utilization pathway, how could lead potential therapeutic approaches.

Language: Английский

Citations

10
The functional regulation between extracellular vesicles and the DNA damage responses DOI
Jin‐Yi Han, Kexin Xu, Ting Xu

et al.

Mutation Research/Reviews in Mutation Research, Journal Year: 2025, Volume and Issue: 795, P. 108532 - 108532

Published: Jan. 1, 2025

Language: Английский

Citations

1
Hypoxia and intrinsic radiosensitivity: Exploring mechanisms in radiation resistance of cancers and biomarkers for enhanced treatment strategies DOI
Elham Khakshour,

Mohammad Amin Shahram,

Reza Chaman

et al.

Journal of Radiation Research and Applied Sciences, Journal Year: 2025, Volume and Issue: 18(2), P. 101450 - 101450

Published: April 3, 2025

Language: Английский

Citations

0
Unravelling the role of extracellular vesicles in cervical cancer: Mechanisms of progression, resistance, and emerging therapeutic strategies DOI Creative Commons
Michelle van der Merwe, Kathryn H. Myburgh, Cathie Garnis

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149467 - 149467

Published: April 1, 2025

Language: Английский

Citations

0
5-aminolevulinic acid photodynamic therapy inhibits the viability, invasion, and migration of cervical cancer SiHa cells by regulating the miR-152-3p/JAK1/STAT1 axis DOI Creative Commons
Xiaochuan Wang, Liangheng Xu, Jingjing Chen

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2024, Volume and Issue: 49, P. 104283 - 104283

Published: July 18, 2024

Cervical cancer ranks the fourth most prevalent type of worldwide, characterized by a notably low survival rate, particularly in its metastatic stage. Despite 5-aminolevulinic acid photodynamic therapy (ALA-PDT) demonstrating potential anti-tumor effects against cervical cancer, intricate mechanisms underlying efficacy necessitate further investigation. Here, study aims to elucidate impact ALA-PDT on cell viability, invasion and migration, alongside delineating molecular mechanisms. SiHa cells were subjected ALA red light irradiation, we then measured ALA-PDT's functions using various assays. The interaction between miR-152-3p JAK1 was explored through bioinformatics analyses validated dual-luciferase reporter Post-transfection with vectors, cellular re-evaluated. tumor suppression investigated transplantation experiment vivo. markedly suppressed impacting critical markers proliferation, apoptosis, epithelial-mesenchymal transition(EMT). And these echoed inhibition miR-152-3p. identified as direct target miR-152-3p, found regulate expression levels consequently influencing JAK1/STAT1 signaling pathway. Augmentation pathway mitigated anti-cancer ALA-PDT, whereas overexpression diminished effects. In vivo demonstrated that growth modulated miR-152-3p/JAK1/STAT1 expression. inhibits invasion, migration modulating axis, offering promising therapeutic avenue for combating invasive cancer.

Language: Английский

Citations

1
The role of extracellular vesicles in the pathogenesis of gynecological cancer DOI Creative Commons

Madhura Chatterjee,

Saurabh Gupta, Tanmoy Mukherjee

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 26, 2024

Gynecological cancer, the most common form of cancers in women worldwide, initiates reproductive organs females. More often, treatment measures, i.e. surgery, radiation, and medical oncology are found to be unsuccessful gynecological tumors. Emerging evidence indicates that extracellular vesicles (EVs) play a significant role pathogenesis by distinct mechanisms. The present review highlights how EVs contribute progression different types such as cervical endometrial ovarian vaginal uterine sarcoma, gestational trophoblastic disease (GTD), vulvar cancer. primary focus is understand EVs’ cargo alters phenotypic response recipient cells, thereby contributing disease, thus can considered prognostic diagnostic biomarker. A brief discussion on diagnosis prognosis cancer also highlighted. Targeting biogenesis EVs, their inside cargo, uptake cells could potential therapeutic approach beside conventional means.

Language: Английский

Citations

1
The signature of extracellular vesicles in hypoxic breast cancer and their therapeutic engineering DOI Creative Commons
Beiqing Zhu,

Kehao Xiang,

Tanghua Li

et al.

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 21, 2024

Abstract Breast cancer (BC) currently ranks second in the global incidence rate. Hypoxia is a common phenomenon BC. Under hypoxic conditions, cells tumor microenvironment (TME) secrete numerous extracellular vesicles (EVs) to achieve intercellular communication and alter metabolism of primary metastatic tumors that shape TME. In addition, emerging studies have indicated hypoxia can promote resistance treatment. Engineered EVs are expected become carriers for treatment due their high biocompatibility, low immunogenicity, drug delivery efficiency, ease modification. this review, we summarize mechanisms TME distant metastasis BC under conditions. Additionally, highlight potential applications engineered mitigating malignant phenotypes hypoxia.

Language: Английский

Citations

1
5-Aminolevulinic Acid Photodynamic Therapy Inhibits the Viability, Invasion, and Migration of Cervical Cancer Siha Cells by Regulating the Mir-152-3p/Jak1/Stat1 Axis DOI
Chunping Ao, Xiaochuan Wang, Liangheng Xu

et al.

Published: Jan. 1, 2024

Download This Paper Open PDF in Browser Add to My Library Share: Permalink Using these links will ensure access this page indefinitely Copy URL DOI

Language: Английский

Citations

0
RNA biomarkers in cancer therapeutics: The promise of personalized oncology DOI
Hector Katifelis, Maria Gazouli

Advances in clinical chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 179 - 219

Published: Jan. 1, 2024

Language: Английский

Citations

0
The role of miR-152 in urological tumors: potential biomarkers and therapeutic targets DOI Creative Commons
Xin Li,

Biao Qian,

Xu Chen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Nov. 13, 2024

Urological malignant tumors pose a significant threat to human health, with high incidence rate each year. Prostate cancer, bladder and renal cell carcinoma are among the most prevalent extensively researched urological malignancies. Despite advancements in research, prognosis for these remains unfavorable due late detection, postoperative recurrence, treatment resistance. A thorough investigation into their pathogenesis is crucial early diagnosis treatment. Recent studies have highlighted close association between microRNAs (miRNAs) cancer progression. miRNAs small non-coding RNAs composed of 19-23 nucleotides that regulate gene expression by binding 3’ untranslated region (3’UTR) target mRNAs, impacting key cellular processes such as proliferation, differentiation, apoptosis, migration. Dysregulation can disrupt oncogenes tumor suppressor genes, contributing development. Among various studied, miR-152 has garnered attention its role Several indicated dysregulation cancers, warranting comprehensive review evidence. This focuses on function prostate carcinoma, elucidating mechanisms progression exploring potential therapeutic biomarker

Language: Английский

Citations

0