miR-574-5p in epigenetic regulation and Toll-like receptor signaling DOI Creative Commons

James Y. Yang

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 26, 2024

miR-574-5p is an unusual microRNA (miRNA) that often upregulated or downregulated following exposure to irradiation toxic chemicals; bacterial, parasitic viral infection; and a variety of other disease conditions. Canonically, epigenetically regulates the expression many messenger RNAs (mRNAs) through miRNA-mediated posttranscriptional regulation, thereby affecting cellular physiology pathophysiology contributing pathogenesis progression diseases. However, recent studies have established in addition serving as fine-tuning repressor gene expression, also stimulates endogenous ligand for Toll-like receptor-8/7 (TLR8/7). Indeed, binding TLR8/7 triggers TLR signaling pathway, leading induction interferons, inflammatory cytokines autoimmune signaling. These findings suggest not only important epigenetic regulator but immune responses. Abnormal miR-574-5p-TLR8/7 has been shown be tightly associated with inflammation-related cancers number disorders. can serve potential biomarker Most importantly, promising therapeutic target treatment prevention human disorders, especially infectious diseases,

Language: Английский

Role of Non-coding RNAs in Rheumatoid Arthritis and Supervision Mechanism of Chinese Medicine DOI
Shu Li, Hong Fang,

Lei Wan

et al.

Chinese Journal of Integrative Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

0
Dysregulated circular RNAs in rheumatoid arthritis: Cellular roles and clinical prospects DOI
Mengshi Tang, Hongxing Li,

Siyuan Chang

et al.

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103774 - 103774

Published: Feb. 1, 2025

Language: Английский

Citations

0
circRNA/TLR interaction: key players in immune regulation and autoimmune diseases DOI
Chou‐Yi Hsu,

Alaa Khalaf Bediwi,

Ahmed Hussein Zwamel

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Novel insights into the crosstalk between non-coding RNA and apoptosis in rheumatoid arthritis: diagnostic functions and therapeutic applications DOI Creative Commons
Jianting Wen, Jian Liu,

Lei Wan

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: May 16, 2025

Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disorder and leading cause of disability worldwide, significantly impairing patients’ quality life. As current therapeutic options remain limited, there an urgent need for novel strategies, including the use medicinal plants, to delay development progression RA. Acute inflammation in RA often accompanied by impaired apoptosis, which contributes disease pathogenesis. With advances high-throughput sequencing technologies, increasing number non-coding RNAs (ncRNAs) have been identified extensively studied their roles both physiological pathological processes. Dysregulation these ncRNAs—particularly long (lncRNAs) circular (circRNAs)—has implicated various disorders, Given well-established association between apoptosis ncRNA expression RA, comprehensive understanding intricate interplay essential. In this study, we systematically explore complex interactions lncRNAs circRNAs regulating during pathogenesis Additionally, highlight emerging evidence, suggesting that ncRNA-mediated modulation can be achieved through herbal medicines, offering promising avenues treatment.

Language: Английский

Citations

0
Highlights on the Effects of Non-Coding RNAs in the Osteonecrosis of the Jaw DOI Open Access
Santino Caserta, Fabio Stagno, Sebastiano Gangemi

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1598 - 1598

Published: Jan. 27, 2024

Osteonecrosis of the jaw is progressive loss and destruction bone affecting maxilla or mandible in patients treated with antiresorptive antiangiogenic agents without receiving prior radiation therapy. The pathogenesis involves inflammatory pathway receptor activator nuclear factor NF-kB ligand macrophage colony-stimulating factor, essential for osteoclast precursors survival proliferation acting through its c-Fms. Evidence has shown role non-coding RNAs osteonecrosis this finding might be useful diagnosis since these small could considered as biomarkers apoptotic activity bone. Interestingly, it been proved that miR-29 miR-31-5p, on specific targets such CALCR RhoA, promote programmed-cell death consequently necrosis tissue. Specific long RNAs, instead, have detected both at reduced levels multiple myeloma osteonecrosis, associated suppression osteoblast differentiation, consequences progression lesions. Among genic material, circular capability to modify expression mRNAs responsible inhibition bisphosphonates osteoclastogenesis.

Language: Английский

Citations

3
The role of non‐coding RNAs in fibroblast‐like synoviocytes in rheumatoid arthritis DOI
Yuexiang Zheng, Xiaoyu Cai,

Fujia Ren

et al.

International Journal of Rheumatic Diseases, Journal Year: 2024, Volume and Issue: 27(10)

Published: Oct. 1, 2024

Abstract Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast‐like synoviocytes (FLSs) constitute the majority of cells in tissue, playing a crucial role onset RA. Dysregulation FLSs function critical strategy treating joint damage associated with Non‐coding RNAs, class RNA molecules that do not encode proteins, participate development various diseases. This article aims to review progress study long non‐coding microRNAs, circular RNAs FLSs. are involved pathogenesis RA, directly or indirectly regulating FLSs' proliferation, migration, invasion, apoptosis, responses. Furthermore, also influence DNA methylation osteogenic differentiation Therefore, hold promise as biomarkers for diagnosing Targeting locally represents potential future therapies

Language: Английский

Citations

2
Current situation and trend of non-coding RNA in rheumatoid arthritis: a review and bibliometric analysis DOI Creative Commons
Zehong Wei,

Huaiyu Li,

Senhao Lv

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 16, 2024

Background Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease that affects multiple joints and has adverse effects on various organs throughout the body, often leading to poor prognosis. Recent studies have shown significant progress in research of non-coding RNAs (ncRNAs) RA. Therefore, this study aims comprehensively assess current status trends ncRNAs RA through bibliometric analysis. Methods This retrieved articles relevant from Science Citation Index Expanded Database Web Core Collection between January 1st, 2003, July 31st, 2023. The were screened based inclusion criteria. VOSviewer CiteSpace are utilized for visual Results A total 1697 publications included study, there was noticeable increase annual China, United States, Kingdom most productive countries field, contributing 43.81%, 13.09%, 3.87% publications. Anhui Medical University Lu Qianjin identified as influential institution author. Frontiers In Immunology stood out prolific journal, while Arthritis & Rheumatology co-cited journal. Additionally, related “circular RNA”, “oxidative stress”, “proliferation”, “migration” emerged new hotspots field. Conclusion we summarized publication characteristics ncRNA countries, institutions, authors, journals, hot topics, trends.

Language: Английский

Citations

2
Circulating microRNAs as biomarkers of chronic kidney disease and its association with renal and cardiovascular outcomes in non-dialysis patients DOI Open Access
Olalla Ramil‐Gómez, Ana Teresa de Abreu Ramos‐Cerqueira, Sara Reis Moura

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 12, 2024

Abstract Chronic kidney disease (CKD) affects over 10% of the population worldwide and entails a significant risk for cardiovascular (CVD), leading to 500-fold increase in mortality advanced stages. Still, pathophysiological mechanisms underlying kidney-heart intercommunication remain largely unknown. In recent years, microRNAs (miRNAs) emerged as important key regulators gene expression that may serve biomarkers several diseases, however, their role crosstalk CKD remains underexplored. this study, we evaluated miRNA panel plasma samples from non-dialysis patients explored association with main comorbidities outcomes 5-year follow-up. Results show miR-30c-5p miR-132-3p were downregulated presenting power discriminate state. Importantly, only was early glomerular filtration rate (GFR) categories, being able these non-diseased individuals. Concerning outcomes, miR-199a-5p found be associated an increased frequency CVD. When analyzing major time, upregulation at baseline mortality, while miR-324-3p who progressed more stages disease. These findings highlight involvement novel circulating miRNAs onset progression, identify, first enrollment crosstalk, paving way establishment new therapeutic targets its outcomes.

Language: Английский

Citations

0
miR-574-5p in epigenetic regulation and Toll-like receptor signaling DOI Creative Commons

James Y. Yang

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 26, 2024

miR-574-5p is an unusual microRNA (miRNA) that often upregulated or downregulated following exposure to irradiation toxic chemicals; bacterial, parasitic viral infection; and a variety of other disease conditions. Canonically, epigenetically regulates the expression many messenger RNAs (mRNAs) through miRNA-mediated posttranscriptional regulation, thereby affecting cellular physiology pathophysiology contributing pathogenesis progression diseases. However, recent studies have established in addition serving as fine-tuning repressor gene expression, also stimulates endogenous ligand for Toll-like receptor-8/7 (TLR8/7). Indeed, binding TLR8/7 triggers TLR signaling pathway, leading induction interferons, inflammatory cytokines autoimmune signaling. These findings suggest not only important epigenetic regulator but immune responses. Abnormal miR-574-5p-TLR8/7 has been shown be tightly associated with inflammation-related cancers number disorders. can serve potential biomarker Most importantly, promising therapeutic target treatment prevention human disorders, especially infectious diseases,

Language: Английский

Citations

0