Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 14, 2024
Comprehensive
Summary
As
one
of
the
famous
traditional
Chinese
herbal
medicines,
Fritillariae
Cirrhosae
Bulbus
(FCB)
is
widely
used
in
prevention
and
treatment
respiratory
diseases
has
best
curative
effect
among
known
fritillarias
medicines.
Due
to
variety,
complex
sources,
similar
appearance
shape,
it
difficult
distinguish
FCB
with
high
(h‐FCB)
from
other
common
(c‐FCB)
market.
In
this
paper,
a
very
simple
chemiresistor
identify
three
commonly
drugs.
The
sensors
are
fabricated
by
anisotropic
electrically
conductive
metal‐organic
framework
(cMOF)
thin
film
Cu
3
(HHTP)
2
(Cu‐HHTP
[001]
Cu‐HHTP
[100]
)
as
active
materials
owing
their
ability
detect
specific
groups
volatile
organic
compounds
(volatolomics)
functional
motifs
chemiresistor.
result,
show
orientation‐dependence
identification
FCB.
‐
based
sensor
shows
highest
response
(344.17%)
0.5
g
h‐FCB
powder
volatiles
its
c‐FCB
which
much
higher
than
(135.50%).
Ultimately,
can
realize
an
accuracy
97.2%
real‐time
manner.
Plants,
Journal Year:
2025,
Volume and Issue:
14(4), P. 523 - 523
Published: Feb. 8, 2025
Broussonetia
papyrifera
(L.)
L'Hér.
ex
Vent.,
a
dioecious
tree
species
that
belongs
to
the
Moraceae
family,
is
perennial
plant
found
extensively
throughout
China.
Its
leaves
are
rich
in
essential
trace
elements
such
as
copper,
molybdenum,
manganese,
and
iron,
well
various
biologically
active
compounds,
including
amino
acids,
polysaccharides,
proteins,
flavonoids,
phenylpropanoids,
other
polyphenolic
compounds.
These
compounds
exhibit
significant
pharmacological
effects,
antioxidant,
lipid-lowering,
heat-clearing,
detoxifying,
blood-cooling,
diuretic,
immunomodulatory
activities.
In
recent
years,
B.
has
gained
attention
for
its
medicinal
potential;
however,
breeding
efforts,
especially
those
aimed
at
increasing
flavonoid
content,
have
lagged.
This
study
reviews
progress
research
on
ingredients
of
papyrifera,
with
focus
identification
methods,
classification
criteria,
enrichment
technologies
components.
The
biosynthesis
structural
genes
transcription
factors
flavonoids
been
investigated
papyrifera.
effects
secondary
metabolites
were
systematically
examined,
aiming
offer
strategies
enhancing
content
promoting
value.
The Plant Journal,
Journal Year:
2025,
Volume and Issue:
121(5)
Published: March 1, 2025
SUMMARY
Fritillaria
unibracteata
var.
wabuensis
is
an
important
resource
plant
for
the
famous
traditional
Chinese
medicine
Fritillariae
cirrhosae
bulbus
(“Chuanbeimu”
in
Chinese).
F.
dried
bulbs
of
several
species
from
genus,
with
isosteroidal
alkaloids
components
assumed
as
bioactive
ingredients.
However,
biosynthesis
pathway
remains
elusive.
Here,
we
adopted
a
material
to
identify
genes
involved
alkaloids.
We
first
constructed
multi‐tissue
metabolome
and
transcriptome
dataset
.
Interestingly,
imperialine‐3‐β‐
d
‐glucoside,
glycoalkaloid,
was
found
be
major
tissue‐specific
accumulated
alkaloid.
Through
phylogenetic
co‐expression
analysis,
identified
two
UDP‐glucosyltransferases
UGT73
family
catalyzing
3‐
O
‐glucosylation
steroidal
alkaloids:
imperialine
‐glucosyltransferase
(FuwI3GT)
can
use
both
alkaloid
solanidine
substrates,
while
(FuwS3GT)
only
substrate.
further
approved
that
W201
residue
FuwI3GT
determined
its
substrate
preference
Overall,
our
results
enzymes
paved
way
fully
elucidate
species.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
12
Published: Jan. 20, 2022
Bulbus
fritillariae
cirrhosae
(BFC)
is
one
of
the
most
used
Chinese
medicines
for
lung
disease,
and
exerts
antitussive,
expectorant,
anti-inflammatory,
anti-asthmatic,
antioxidant
effects,
which
an
ideal
therapeutic
drug
respiratory
diseases
such
as
ARDS,
COPD,
asthma,
cancer,
pulmonary
tuberculosis.
Through
this
review,
it
found
that
mechanism
BFC
on
exhibits
characteristics
multi-components,
multi-targets,
multi-signaling
pathways.
In
particular,
potential
in
terms
intervention
"cytokine
storm",
STAT,
NF-κB,
MAPK
signaling
pathways,
well
renin-angiotensin
system
(RAS)
ACE
involved
in.
storm"
SARS-CoV-2
infection
there
intense
inflammatory
response.
ACE2
regulates
RAS
by
degradation
Ang
II
produced
ACE,
associated
with
SARS-CoV-2.
For
COVID-19,
may
be
a
drug?
This
review
summarized
research
progress
diseases,
discussed
development
potentiality
treatment
explained
chemical
diversity
biological
significance
alkaloids
BFC,
clarified
material
basis,
molecular
targets,
pathways
diseases.
We
hope
can
provide
insights
discovery
anti-COVID-19.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: Nov. 30, 2022
Fritillaria
cirrhosa
D.
Don
and
F.
thunbergii
Miq.
belong
to
the
genus
within
Liliaceae
family.
They
are
used
in
traditional
Chinese
medicines
that
often
administered
clinical
settings
as
they
have
notable
effects
on
cough,
bronchitis,
pneumonia,
lung
injury,
cancer,
other
diseases.
In
this
review,
we
focus
history,
origin,
similarities,
differences
efficacy,
chemical
composition,
pharmacological
outcomes
of
drugs
obtained
from
(FRC)
(FRT).
We
list
various
valuable
FRC
FRT,
including
antitussive,
expectorant,
anti-inflammatory,
antioxidant,
anticancer
effects.
Thus,
review
offers
a
basis
for
medical
application
further
research
into
impacts
these
two
drugs.
believe
new
derived
phytoconstituents
specific
therapeutic
properties
can
be
developed
future.
