Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Dec. 8, 2022
Adult
neurogenesis
is
the
process
of
differentiation
neural
stem
cells
(NSCs)
into
neurons
and
glial
in
certain
areas
adult
brain.
Defects
can
lead
to
neurodegenerative
diseases,
mental
disorders,
other
maladies.
This
directionally
regulated
by
transcription
factors,
Wnt
Notch
pathway,
extracellular
matrix,
various
growth
factors.
External
factors
like
stress,
physical
exercise,
diet,
medications,
etc.,
affect
gut
microbiota.
The
microbiota
may
NSCs
through
vagal,
immune
chemical
pathways,
pathways.
Traditional
Chinese
medicine
(TCM)
has
been
proven
proliferation
regulate
abundance
metabolites
produced
intestinal
microorganisms.
However,
underlying
mechanisms
which
these
are
not
fully
understood.
In
this
review,
we
describe
recent
evidence
on
role
neurogenesis.
Moreover,
hypothesize
characteristics
microbiota-gut-brain
axis
based
bacterial
phyla,
including
microbiota’s
metabolites,
neuronal
pathways
while
providing
an
outlook
TCM’s
potential
effects
regulating
Deleted Journal,
Journal Year:
2023,
Volume and Issue:
13(1), P. 414 - 420
Published: April 14, 2023
Parkinson's
disease
(PD)
is
a
common
neurodegenerative
disorder
with
no
cure.
Astragalus
membranaceus
used
in
Chinese
culture
as
food
supplement
to
boost
immunity.
The
present
study
aimed
explore
the
neuroprotective
effects
of
total
flavonoids
extracted
from
A.
(TFA)
and
their
protective
mechanisms.
TFA
offered
neuroprotection
against
1-methyl-4-phenyl-1,2,3,6
-tetrahydropyridine
(MPTP)
mouse
model
Parkinsonism,
by
improving
behavior
performance
gait
analysis
pole
test,
inhibiting
decline
tyrosine
hydroxylase
(TH)
positive
neurons
TH
protein
expression
Substantia
Nigra
mice.
also
prevented
1-methyl-4-
phenylpyridinium
(MPP+)-induced
neurotoxicity
SH-SY5Y
cells,
increasing
GSH
GSH/GSSG
ratio,
reducing
reactive
oxygen
species.
In
addition,
were
associated
its
ability
restore
MPTP/MPP+-induced
downregulation
SLC7A11
glutathione
peroxidase
4
(GPX-4).
conclusion,
we
demonstrated
that
exerted
significant
MPTP/MPP+
induced
neurodegeneration
ferroptosis
through
regulation
SLC7A11/GPX-4
axis,
suggesting
use
possible
prevention
PD.
iMetaOmics.,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 11, 2025
Abstract
Epidemiological
studies
suggest
a
link
between
type
2
diabetes
mellitus
(T2DM)
and
Alzheimer's
disease
(AD),
possibly
due
to
gut
microbiota
dysbiosis,
although
the
exact
mechanisms
are
unclear.
This
narrative
review
uniquely
addresses
how
microbiota‐derived
metabolites
mediate
overlapping
pathologies
of
insulin
resistance,
neuroinflammation,
amyloidogenesis
in
T2DM
AD,
proposing
framework
for
dual
therapeutic
targeting.
provides
an
in‐depth
examination
roles
their
context
AD.
study
indicates
that
dysbiosis
significantly
impacts
pathogenesis
progression
both
diseases
by
modulating
metabolic
pathways,
immune
functions,
inflammatory
responses.
Key
bacteria,
such
as
Akkermansia
muciniphila
(which
releases
outer
membrane
vesicles),
Lactobacillus
,
Bifidobacterium
well
like
short‐chain
fatty
acids
(SCFAs),
bile
(BAs),
lipopolysaccharide
(LPS),
vitamins,
Trimethylamine
N‐oxide
(TMAO)
regulate
AD
through
complex
mechanisms.
Multiple
signaling
including
G‐protein
coupled
receptor
41/43
(GPR41/43),
phosphoinositide
3‐kinase
(PI3K)/protein
kinase
B
(Akt),
Toll‐like
4
(TLR4)/nuclear
factor
kappa‐light‐chain‐enhancer
activated
cells
(NF‐κB),
endoplasmic
reticulum
(ER)
stress‐mediated
also
involved.
These
findings
offer
insights
into
potential
targeted
therapies
Heliyon,
Journal Year:
2023,
Volume and Issue:
9(3), P. e14171 - e14171
Published: March 1, 2023
Diabetic
nephropathy
(DN)
is
the
primary
cause
of
end-stage
renal
disease
worldwide.
Although
etiology
for
DN
complex
and
still
needs
to
be
fully
understood,
lipid
metabolism
disorder
found
play
a
role
in
it.
Previously,
we
Yishen
Huashi
(YSHS)
granule
could
inhibit
diabetic
damage
reduce
level
microalbuminuria
(mALB)
animals.
To
explore
its
mechanism
under
settings,
this
study
was
designed.DN
rats
were
induced
by
streptozotocin
(STZ),
HepG2
CaCO2
cells
applied
vitro
study.
Hematoxylin-Eosin
(HE),
periodic
acid-Schiff
(PAS)
staining,
Transmission
Electron
Microscopy
(TEM)
histological
observation;
16s
Sequencing
used
intestinal
microbiota
composition
analysis;
western
blotting
(WB)
immunofluorescence
carried
out
molecular
biological
study,
enzyme-linked
immunosorbent
assay
(ELISA)
determination.YSHS
administration
significantly
reduced
levels
total
cholesterol
(TC),
triglyceride
(TG),
low-density
lipoprotein
(LDL-C),
while
increased
high-density
(HDL-C);
meanwhile,
changes
steatosis
liver
ameliorated,
integrity
barrier
enhanced,
dysbacteriosis
within
lumen
ameliorated.
Mechanism
that
YSHS
modulated
mitophagy
hepatocytes
inhibited
mTOR/AMPK/PI3K/AKT
signaling
pathway.In
conclusion,
present
ameliorate
animals,
modulation
on
intestinal-liver
axis
played
significant
Critical Reviews in Food Science and Nutrition,
Journal Year:
2023,
Volume and Issue:
64(28), P. 10281 - 10302
Published: June 10, 2023
Aging-related
cognitive
impairment,
mainly
Alzheimer's
disease
(AD),
has
been
widely
studied.
However,
effective
prevention
and
treatment
methods
are
still
lacking.
In
recent
years,
researchers
have
observed
beneficial
effects
of
plant-based
supplements,
such
as
flavonoids,
on
protection.
This
provides
a
new
clue
for
the
dysfunction.
Studies
shown
that
dietary
flavonoids
neuroprotective
effects,
but
mechanism
is
not
clear.
this
review,
we
systematically
reviewed
research
progress
gut
microbes
their
metabolites,
concluded
could
improve
function
through
gut-brain
axis.
Flavonoids
can
be
absorbed
intestine,
cross
blood-brain
barrier,
enter
brain
tissue.
inhibit
expression
secretion
inflammatory
factors
in
tissue,
reduce
damage
caused
by
oxidative
stress,
clear
neural
proteins
neuronal
apoptosis,
thereby
ameliorating
age-related
disorders.
Future
work
will
continue
to
explore
axis
target
genes
regulated
flavonoids.
addition,
clinical
its
mechanisms
need
further
explored
provide
solutions
or
advise
patients
with
impairment.
Nutrients,
Journal Year:
2023,
Volume and Issue:
15(18), P. 3912 - 3912
Published: Sept. 8, 2023
Oxidative
stress
is
a
common
characteristic
of
psychiatric,
neurological,
and
neurodegenerative
disorders.
Therefore,
compounds
that
are
neuroprotective
reduce
oxidative
may
be
interest
as
novel
therapeutics.
Phenolic,
flavonoid
anthocyanin
content,
ORAC
DPPH
free
radical
scavenging,
Cu2+
Fe2+
chelating
capacities
were
examined
in
variations
(fresh/capsule)
Queen
Garnet
plum
(QGP,
Prunus
salicina),
black
pepper
(Piper
nigrum)
clove
(Syzygium
aromaticum),
elderberry
(Sambucus
nigra),
lemon
balm
(Melissa
officinalis)
sage
(Salvia
officinalis),
plus
two
blends
(Astralagus
membranaceus-lemon
balm-rich,
WC
R8).
The
ability
samples
to
prevent
treat
H2O2-induced
SH-SY5Y
cells
was
investigated.
Pre-treatment
with
WC,
elderberry,
QGP,
prevented
the
stress-induced
reduction
cell
viability,
demonstrating
effect.
Elderberry
increased
viability
following
induction,
treatment
effects.
Clove
had
highest
phenolic
DPPH,
capacities,
whereas
QGP
anthocyanins.
Black
capacity.
These
findings
demonstrate
plant
extracts
can
apoptosis
neuron-like
vitro.
Further
research
into
phytochemicals
therapeutics
for
brain
needed.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: July 15, 2022
Cognitive
dysfunction
is
a
critical
complication
of
diabetes
mellitus,
and
there
are
still
no
clinically
approved
drugs.
Zi
Shen
Wan
Fang
(ZSWF)
an
optimized
prescription
composed
Anemarrhenae
Rhizoma,
Phellodendri
Chinensis
Cortex,
Cistanches
Herba.
The
purpose
this
study
to
investigate
the
effect
ZSWF
on
DCI
explore
its
mechanism
from
perspective
maintaining
intestinal
microbial
homeostasis
in
order
find
effective
for
treating
DCI.
