Small,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 16, 2024
Abstract
Nanozymes
with
multienzyme‐like
activity
have
sparked
significant
interest
in
anti‐tumor
therapy
via
responding
to
the
tumor
microenvironment
(TME).
However,
consequent
induction
of
protective
autophagy
substantially
compromises
therapeutic
efficacy.
Here,
a
targeted
nanozyme
system
(Fe‐Arg‐CDs@ZIF‐8/HAD,
FZH)
is
shown,
which
enhances
synergistic
ferroptosis/apoptosis
by
leveraging
machine
learning
(ML).
A
novel
ML
model,
termed
sequential
backward
Tree‐Classifier
for
Gaussian
Process
Regression
(TCGPR),
proposed
improve
data
pattern
recognition
following
divide‐and‐conquer
principle.
Based
on
this,
Bayesian
optimization
algorithm
employed
select
candidates
from
extensive
search
space.
Leveraging
this
fresh
material
discovery
framework,
strategy
enhancing
nanozyme‐based
therapy,
has
been
developed.
The
results
reveal
that
FZH
effectively
exerts
effects
sequentially
TME,
having
cascade
reaction
induce
ferroptosis.
Moreover,
endogenous
elevation
high
concentration
nitric
oxide
(NO)
serves
as
direct
mechanism
killing
cells
while
concurrently
suppressing
induced
oxidative
stress
(OS),
therapy.
Overall,
improving
proposed,
underlying
integration
ML,
experiments,
and
biological
applications.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 23, 2024
Ferroptosis
is
a
non-apoptotic
mode
of
programmed
cell
death
characterized
by
iron
dependence
and
lipid
peroxidation.
Since
the
ferroptosis
was
proposed,
researchers
have
revealed
mechanisms
its
formation
continue
to
explore
effective
inhibitors
in
disease.
Recent
studies
shown
correlation
between
pathological
neurodegenerative
diseases,
as
well
diseases
involving
tissue
or
organ
damage.
Acting
on
ferroptosis-related
targets
may
provide
new
strategies
for
treatment
ferroptosis-mediated
diseases.
This
article
specifically
describes
metabolic
pathways
summarizes
reported
action
natural
synthetic
small
molecule
their
efficacy
The
paper
also
treatments
such
gene
therapy,
nanotechnology,
summarises
challenges
encountered
clinical
translation
inhibitors.
Finally,
relationship
other
modes
discussed,
hopefully
paving
way
future
drug
design
discovery.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(23), P. 13042 - 13042
Published: Dec. 4, 2024
Parkinson's
disease
(PD)
is
a
common
neurodegenerative
disorder
characterized
by
the
loss
of
dopaminergic
neurons
in
substantia
nigra
and
accumulation
α-synuclein
brain.
Ferroptosis,
recently
identified
form
regulated
cell
death,
critical
PD
pathogenesis
due
to
its
association
with
iron
deposition,
overproduction
reactive
oxygen
species,
iron-dependent
lipid
peroxidation
impaired
clearance.
This
death
mechanism
closely
linked
several
pathogenic
processes
PD,
including
aggregation,
oxidative
stress,
mitochondrial
dysfunction,
microglia-induced
neuroinflammation,
neuromelanin
accumulation.
Given
significant
role
ferroptosis
these
mechanisms,
there
increasing
interest
targeting
for
treatment.
Several
drugs
have
shown
potential
alleviating
symptoms
inhibiting
ferroptosis.
review
aims
consolidate
current
knowledge
on
assess
therapeutic
anti-ferroptosis
drugs,
highlighting
promising
directions
future
research
clinical
applications.
Open Medicine,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 1, 2025
This
study
aims
to
investigate
the
role
and
mechanism
of
p-hydroxyl
cinnamaldehyde
(CMSP)
in
triggering
ferroptosis
small
cell
lung
cancer
(SCLC)
cells.
The
impact
CMSP
on
H1688
SW1271
cells
was
assessed
through
experiments
biological
information
analysis.
Moreover,
expression
heme
oxygenase
1
(HMOX1)
SCLC
tissue
examined.
Following
treatment,
a
concentration-dependent
increase
death
observed,
differentially
expressed
genes
were
found
be
associated
with
ferroptosis.
notably
facilitated
events,
such
as
elevated
levels
reactive
oxygen
species
(ROS),
Fe2+,
malondialdehyde
(MDA),
transferrin
receptor
(TFR1),
divalent
metal
transporter
(DMT1),
decreased
glutathione
(GSH),
solute
carrier
family
7
member
11
(SLC7A11),
peroxidase
4
(GPX4).
Furthermore,
promoted
mitochondrial
dysfunction,
manifested
reduced
volume,
increased
membrane
density,
ROS,
potential.
Consistently,
mitochondrial-targeted
antioxidant
Mito-TEMPO
reversed
CMSP-induced
Expression
HMOX1
gene
markedly
under
while
lower
observed
compared
adjacent
tissue.
triggers
dysfunction
via
activation,
leading
cells,
underscoring
its
potential
therapeutic
agent
for
SCLC.
Frontiers in Pharmacology,
Journal Year:
2025,
Volume and Issue:
16
Published: May 16, 2025
Astragalus
L.,
the
world’s
largest
vascular
plant
genus,
has
been
used
medicinally
and
as
food
for
centuries,
especially
in
traditional
Chinese
medicine
It
is
widely
applied
immune
modulation,
antioxidant
therapy,
anti-inflammatory
treatments,
antitumor
applications.
Recent
studies
show
that
species
rich
bioactive
compounds,
such
polysaccharides,
flavonoids,
saponins,
alkaloids,
simple
phenolics,
which
demonstrate
significant
pharmacological
effects,
including
anti-inflammatory,
antioxidant,
immunomodulatory,
properties,
along
with
potential
benefits
Alzheimer’s
disease
diabetes.
This
review
synthesizes
140
references
to
analyze
51
newly
identified
31
triterpenoid
19
alkaloids
(2020–2025),
focusing
on
their
chemical
structures
bioactivities.
also
examines
homology
(MFH)
how
processing
methods
affect
its
efficacy.
Furthermore,
mechanisms
behind
immune-boosting,
antitumor,
neuroprotective,
hypoglycemic
effects
are
discussed.
Future
should
prioritize
large-scale
clinical
trials
confirm
’s
efficacy
safety,
explore
combination
therapies,
improve
sustainable
resource
utilization
expand
medical
Keywords:
Bioactive
molecules,
,
Pharmacological
action,
Mechanism
of
Medicine
(MFH).
