Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Dec. 8, 2022
Adult
neurogenesis
is
the
process
of
differentiation
neural
stem
cells
(NSCs)
into
neurons
and
glial
in
certain
areas
adult
brain.
Defects
can
lead
to
neurodegenerative
diseases,
mental
disorders,
other
maladies.
This
directionally
regulated
by
transcription
factors,
Wnt
Notch
pathway,
extracellular
matrix,
various
growth
factors.
External
factors
like
stress,
physical
exercise,
diet,
medications,
etc.,
affect
gut
microbiota.
The
microbiota
may
NSCs
through
vagal,
immune
chemical
pathways,
pathways.
Traditional
Chinese
medicine
(TCM)
has
been
proven
proliferation
regulate
abundance
metabolites
produced
intestinal
microorganisms.
However,
underlying
mechanisms
which
these
are
not
fully
understood.
In
this
review,
we
describe
recent
evidence
on
role
neurogenesis.
Moreover,
hypothesize
characteristics
microbiota-gut-brain
axis
based
bacterial
phyla,
including
microbiota’s
metabolites,
neuronal
pathways
while
providing
an
outlook
TCM’s
potential
effects
regulating
Molecules,
Journal Year:
2023,
Volume and Issue:
28(16), P. 6115 - 6115
Published: Aug. 18, 2023
Astragalus
membranaceus
(Fisch.)
Bge.
var.
mongholicus
(Bge.)
P.
K.
Hsiao
(MO)
and
Bug.
(ME)
are
two
primary
sources
of
the
herb,
also
known
as
“Huangqi”
in
China,
which
is
widely
applied
to
treat
hypertension,
glomerulonephritis,
ischemic
heart
disease,
diabetes
mellitus.
As
different
chemical
profiles
MO
ME
may
be
different.
Previous
studies
showed
abundant
differences
composition
between
ME.
Therefore,
by-products
ME,
such
flower
(MOF)
(MEF),
have
phytochemical
profiles.
In
this
paper,
a
metabolomics
method
combined
with
ultra-high-performance
liquid
chromatography
electrospray
ionization/quadrupole
time-of-flight
mass
spectrometry
(UHPLC−Q−TOF−MS/MS)
was
employed
analyze
components
MOF
MEF.
Consequently,
results
principal
component
analysis
(PCA)
that
MEF
could
separated
clearly.
total,
31
markers
differentiating
were
successfully
identified,
including
22
flavonoids,
8
isoflavones
1
benzopyran.
Among
them,
contents
18
components,
Calycosin,
Cyanidin-3-O-glucoside,
Quercetin,
Rutin,
Kaempferol,
Formononetin,
Isomucronulatol
Prim-O-glucosylcimifugin
MEF,
significantly
higher
than
MOF.
turn,
another
13
covering
Biochanin
A,
Tectoridin,
Isomucronulatol-7-O-glucoside,
Liquiritin,
Rhamnetin,
etc.,
lower
group
group.
It
worth
noting
especially
flavonoid
glycosides,
active
ingredients
The
level
carried
out
diverse
activities,
like
anti-oxidant,
anti-inflammatory,
anti-bacterial
anti-tumor
led
us
speculate
greater
pharmacological
effects
potential
development
prospects
present
displayed
species
plants
radically
different,
there
significant
uniqueness
Our
study
not
only
provides
helpful
information
for
further
quality
assessment
mechanism
research
but
offers
scientific
support
resource
utilization
Molecules,
Journal Year:
2024,
Volume and Issue:
29(12), P. 2747 - 2747
Published: June 9, 2024
Currently,
an
estimated
537
million
individuals
are
affected
by
type
2
diabetes
mellitus
(T2DM),
the
occurrence
of
which
is
invariably
associated
with
complications.
Glucose-lowering
therapy
remains
main
treatment
for
alleviating
T2DM.
However,
conventional
antidiabetic
agents
fraught
numerous
adverse
effects,
notably
elevations
in
blood
pressure
and
lipid
levels.
Recently,
use
traditional
Chinese
medicines
(TCMs)
their
constituents
has
emerged
as
a
preferred
management
strategy
aimed
at
curtailing
progression
its
complications
fewer
effects.
Increasing
evidence
indicates
that
gut
microbiome
disturbances
involved
development
T2DM
This
regulation
depends
on
various
metabolites
produced
microbes
interactions
host
organs.
TCMs’
interventions
have
demonstrated
ability
to
modulate
intestinal
bacterial
microbiota,
thereby
restoring
homeostasis
ameliorating
metabolic
disorders.
review
delves
into
alterations
microbiota
patients
how
TCMs
regulates
facilitating
Additionally,
we
also
discuss
prospective
avenues
research
natural
products
advance
therapy.
Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(28), P. 8569 - 8581
Published: July 11, 2022
Diabetes
mellitus
(DM)
is
a
serious
metabolic
disease
characterized
by
persistent
hyperglycemia,
with
continuously
increasing
morbidity
and
mortality.
Although
traditional
treatments
including
insulin
oral
hypoglycemic
drugs
maintain
blood
glucose
levels
within
the
normal
range
to
certain
extent,
there
an
urgent
need
develop
new
that
can
effectively
improve
metabolism
diabetes-related
complications.
Notably,
accumulated
evidence
implicates
gut
microbiota
unbalanced
in
DM
individuals
involved
physiological
pathological
processes
of
this
disease.
In
review,
we
introduce
molecular
mechanisms
which
contributes
development
DM.
Furthermore,
summarize
preclinical
studies
bioactive
natural
products
exert
antidiabetic
effects
modulating
microbiota,
aiming
expand
novel
therapeutic
strategies
for
prevention
management.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2022,
Volume and Issue:
12
Published: Dec. 8, 2022
Adult
neurogenesis
is
the
process
of
differentiation
neural
stem
cells
(NSCs)
into
neurons
and
glial
in
certain
areas
adult
brain.
Defects
can
lead
to
neurodegenerative
diseases,
mental
disorders,
other
maladies.
This
directionally
regulated
by
transcription
factors,
Wnt
Notch
pathway,
extracellular
matrix,
various
growth
factors.
External
factors
like
stress,
physical
exercise,
diet,
medications,
etc.,
affect
gut
microbiota.
The
microbiota
may
NSCs
through
vagal,
immune
chemical
pathways,
pathways.
Traditional
Chinese
medicine
(TCM)
has
been
proven
proliferation
regulate
abundance
metabolites
produced
intestinal
microorganisms.
However,
underlying
mechanisms
which
these
are
not
fully
understood.
In
this
review,
we
describe
recent
evidence
on
role
neurogenesis.
Moreover,
hypothesize
characteristics
microbiota-gut-brain
axis
based
bacterial
phyla,
including
microbiota’s
metabolites,
neuronal
pathways
while
providing
an
outlook
TCM’s
potential
effects
regulating
