Roles of ferroptosis in the development of diabetic nephropathy DOI
Pan Liu, Zhengdong Zhang, Chen Qiu

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: 53(6), P. 708 - 714

Published: Dec. 1, 2024

Diabetic nephropathy is a common microvascular complication of diabetes mellitus and one the main causes death in patients with mellitus. Ferroptosis newly discovered iron-dependent regulated cell death, which may contribute to pathogenesis development diabetic nephropathy. Adenosine monophosphate-activated protein kinase (AMPK)-mediated ferroptosis-related signaling pathways can slow down progression nephropathy, but excessive activation AMPK pathway induce cells undergo autophagic death. Activation mediated by nuclear factor-erythroid 2-related factor (Nrf) 2 heme oxygenase (HO)-1 inhibit ferroptosis alleviate However, regulatory effect HO-1 on bidirectional, HIF-1α/HO-1 lead intracellular iron overload ultimately promote ferroptosis. Transforming growth (TGF)-β1 accelerate lipid peroxidation down-regulating levels SLC7A11/GSH/GPX4. The exosome lncRNAs/circRNAs/miRNAs are also involved In addition, stimulator interferon gene (STING) novel promoter acyl-CoA synthetase long-chain family (ACSL) 1 this review, we focus roles through AMPK, Nrf2/HO-1, TGF-β exosomes, elaborate potential therapeutic target for

Language: Английский

Effective protective mechanisms of HO-1 in diabetic complications: a narrative review DOI Creative Commons
Jingjing Zhang, Ping Ni, Yi Song

et al.

Cell Death Discovery, Journal Year: 2024, Volume and Issue: 10(1)

Published: Oct. 10, 2024

Diabetes mellitus is a metabolic disorder with persistent hyperglycemia caused by variety of underlying factors. Chronic can lead to diverse serious consequences and diversified complications, which pose threat patients. Among the major complications are cardiovascular disease, kidney diabetic foot ulcers, retinopathy, neurological disorders. Heme oxygenase 1 (HO-1) protective enzyme antioxidant, anti-inflammatory anti-apoptotic effects, has been intensively studied plays an important role in complications. By inducing expression activity HO-1, it enhance anti-inflammatory, capacity tissues, thus reduce degree damage The present study aims review relationship between HO-1 pathogenesis diabetes its involved regulation macrophage polarization promotes M1 state (pro-inflammatory) towards M2 (anti-inflammatory). Induction dendritic cells inhibits them maturation secretion pro-inflammatory cytokines regulatory T cell (T

Language: Английский

Citations

4
SR-B1 deficiency suppresses progression in acute myeloid leukemia via ferroptosis and reverses resistance to venetoclax DOI
Junfeng Shi, Yifeng Cheng, Lixue Wang

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

Citations

0
Iron Metabolism and Ferroptosis in Diabetic Kidney Disease DOI

Fangxin Mu,

Ping Luo, Yuexin Zhu

et al.

Cell Biochemistry and Function, Journal Year: 2025, Volume and Issue: 43(4)

Published: April 1, 2025

ABSTRACT Diabetic kidney disease (DKD) is a major diabetic microvascular complication that still lacks effective therapeutic drugs. Ferroptosis recently identified form of programmed cell death triggered by iron overload. It characterized unrestricted lipid peroxidation and subsequent membrane damage found in various diseases. Accumulating evidence has highlighted the crucial roles overload ferroptosis DKD. Here, we review metabolism biology ferroptosis. The role aberrant inducing diverse renal intrinsic death, oxidative stress, fibrosis DKD summarized, elaborate on critical regulatory factors related to Finally, focused significance treatment highlight recent data regarding novel activities some drugs as inhibitors DKD, aiming provide new research targets strategies

Language: Английский

Citations

0
Modulation of renal fibrosis-related signaling pathways by traditional Chinese medicine: molecular mechanisms and experimental evidence DOI
Yufei Yang, Longshan Zhao, Fengli Gao

et al.

International Urology and Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

Citations

0
Metal-Dependent Cell Death in Renal Fibrosis: Now and in the Future DOI Open Access
Te Li, Chen Yu

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13279 - 13279

Published: Dec. 11, 2024

Renal fibrosis is a common final pathway underlying nearly almost all progressive kidney diseases. Metal ions are essential trace elements in organisms and involved important physiological activities. However, aberrations intracellular metal ion metabolism may disrupt homeostasis, causing cell death increasing susceptibility to various Accumulating evidence suggests complex association between metal-dependent renal fibrosis. In this article, we provide comprehensive overview of the specific molecular mechanisms their crosstalk, up-to-date supporting role fibrosis, therapeutic targeting strategies, research needs, aiming offer rationale for future clinical treatment

Language: Английский

Citations

1
Explore the mechanism of mulberry leaf combined with gut microbiota to improve hyperlipidemia based on network pharmacology DOI Creative Commons
S. Wang, Jiali Zhou,

Zhi Xu Zhang

et al.

Discover Plants., Journal Year: 2024, Volume and Issue: 1(1)

Published: Sept. 27, 2024

Language: Английский

Citations

0
Comparative Analysis of Volatile Components in Chi-Nan and Ordinary Agarwood Aromatherapies: Implications for Sleep Improvement DOI Creative Commons

Zixiao Jiang,

Junyu Mou,

Jian Feng

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(9), P. 1196 - 1196

Published: Sept. 11, 2024

Agarwood, a precious traditional medicinal herb and fragrant material, is known for its sedative sleep-improving properties. This study explores the mechanisms underlying aromatherapy effects of Chi-Nan agarwood ordinary in improving sleep. Using combination gas chromatography–mass spectrometry (GC-MS), network pharmacology, molecular docking techniques, we identified c ompared chemical compositions potential targets both types agarwood. The GC-MS analysis detected 87 volatile components across six aromatherapy, with 51 shared between agarwood, while each type also had 18 unique components. Ordinary was found to be richer sesquiterpenes small aromatic molecules, whereas contained higher levels chromones. These differences composition are likely responsible distinct observed two Through 100, 65, 47 non-repetitive target genes related sleep improvement were by (CSBTs), common (CUCMs), (CUCNs), respectively. constructed protein–protein interaction (PPI) networks revealed that key such as MAOA, MAOB, SLC6A4, ESR1 involved aromatherapy. Molecular further confirmed strong binding affinities major active components, 5-Isopropylidene-6-methyldeca-369-trien-2-one 2-(2-Phenylethyl)chromone, these core targets. results suggest enhances quality through hormonal neurotransmitter pathways, more deeply mediating regulation, predominantly influences particularly those involving serotonin GABA. provides valuable insights into therapeutic potentials highlighting their roles offering foundation future research clinical application agarwood-based

Language: Английский

Citations

0
Roles of ferroptosis in the development of diabetic nephropathy DOI
Pan Liu, Zhengdong Zhang, Chen Qiu

et al.

Journal of Zhejiang University (Medical Sciences), Journal Year: 2024, Volume and Issue: 53(6), P. 708 - 714

Published: Dec. 1, 2024

Diabetic nephropathy is a common microvascular complication of diabetes mellitus and one the main causes death in patients with mellitus. Ferroptosis newly discovered iron-dependent regulated cell death, which may contribute to pathogenesis development diabetic nephropathy. Adenosine monophosphate-activated protein kinase (AMPK)-mediated ferroptosis-related signaling pathways can slow down progression nephropathy, but excessive activation AMPK pathway induce cells undergo autophagic death. Activation mediated by nuclear factor-erythroid 2-related factor (Nrf) 2 heme oxygenase (HO)-1 inhibit ferroptosis alleviate However, regulatory effect HO-1 on bidirectional, HIF-1α/HO-1 lead intracellular iron overload ultimately promote ferroptosis. Transforming growth (TGF)-β1 accelerate lipid peroxidation down-regulating levels SLC7A11/GSH/GPX4. The exosome lncRNAs/circRNAs/miRNAs are also involved In addition, stimulator interferon gene (STING) novel promoter acyl-CoA synthetase long-chain family (ACSL) 1 this review, we focus roles through AMPK, Nrf2/HO-1, TGF-β exosomes, elaborate potential therapeutic target for

Language: Английский

Citations

0