Role of Nanotechnology in Ischemic Stroke: Advancements in Targeted Therapies and Diagnostics for Enhanced Clinical Outcomes

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 8 - 8

Published: Jan. 1, 2025

Each year, the number of cases strokes and deaths due to this is increasing around world. This could be work stress, lifestyles, unhealthy food habits, several other reasons. Currently, there are traditional methods like thrombolysis mechanical thrombectomy for managing strokes. The current approach has limitations, delayed diagnosis, limited therapeutic delivery, risks secondary injuries. So, a need some effective reliable management strokes, which help in early diagnosis followed by treatment Nanotechnology played an immense role recently, it emerged as transformative solution offering innovative diagnostic tools strategies. Nanoparticles (NPs) belonging classes, including metallic (metallic metal oxide), organic (lipids, liposome), carbon, can cross blood–brain barrier may exhibit potential various Moreover, these NPs have exhibited promise improving imaging specificity delivery precise drug real-time monitoring efficacy. Nanomaterials cerium oxide (CeO2) liposome-encapsulated agents neuroprotective properties that reduce oxidative stress promote neuroregeneration. In present article, authors emphasized significant advancements nanomedicine stroke, NPs-based systems, neuroregenerative therapies, multimodal advancements.

Language: Английский

---

Metabolic profiling of abdominal subcutaneous adipose tissue reveals effects of apple polyphenols for reversing high-fat diet induced obesity in C57BL/6 J mice

Food Chemistry, Journal Year: 2025, Volume and Issue: 473, P. 143055 - 143055

Published: Jan. 27, 2025

Language: Английский

---

Analysis of Blood Absorption Components by UPLC‐Q‐TOF‐MS/MS From Anemarrhenae Rhizoma Before and After Salt Processing

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 12, 2025

ABSTRACT To investigate the material basis for increased efficacy of Anemarrhenae Rhizoma (AR) after salt processing, this study employed UPLC‐Q‐TOF‐MS/MS technology to analyze metabolites in both AR and salt‐processed (SAR) extracts, as well serum samples treated with these extracts. The results identified 54 chemical components SAR under positive negative ion modes, 21 prototype detected bloodstream. A comparative analysis absorption levels revealed higher concentrations neomangiferin, mangiferin, other constituents group than group. Additionally, 29 differential were identified, 12 unique 17 SAR. These findings highlight significant alterations composition processing provide a scientific understanding enhanced This offers valuable insights further research into clinical its applications.

Language: Английский

---

Unveiling the multifaceted potential of Amaranthus viridis L.: a review of its phytochemistry, pharmacology, and industrial applications

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104967 - 104967

Published: March 1, 2025

Language: Английский

---

Impact of aneurysm sac size on the effectiveness of endovascular coiling in patient-specific middle cerebral artery aneurysms: a computational study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 14, 2025

This study investigates the hemodynamic efficiency of endovascular coiling in treatment patient-specific middle cerebral artery (MCA) aneurysms using computational models both original and scaled-down geometries. Computational fluid dynamic (CFD) is used for blood flow modelling inside aneurysms. The Casson non-Newtonian model employed to simulate dynamics, while a porous condition represents within aneurysm sac. Key factors, including wall shear stress (WSS) oscillatory index (OSI), are analyzed evaluate effectiveness across different sizes. Results indicate that significantly reduces rupture risk, with larger sac volumes demonstrating more pronounced decrease high-risk zones. These findings offer insights into optimizing treatments varying morphologies.

Language: Английский

---

Investigating hemodynamic factors and rupture risk in internal carotid artery aneurysms: A computational and statistical analysis

Physics of Fluids, Journal Year: 2025, Volume and Issue: 37(3)

Published: March 1, 2025

This study investigates the role of hemodynamic factors in assessing rupture risk intracranial internal carotid artery saccular aneurysms. A total 24 unruptured and 12 ruptured aneurysms were analyzed using computational fluid dynamics statistical methods to identify meaningful relationships between parameters risk. Key metrics, including maximum, mean, minimum values blood velocity, oscillatory shear index (OSI), statistically compared. The Weibull model was employed evaluate potential connections these aneurysm rupture. spatial distribution mapped on sac surface high-risk regions prone Results revealed that exhibit lower maximum velocity compared ones. Additionally, demonstrated higher OSI values, highlighting a distinct difference profiles. These findings provide valuable insights into biomechanical influencing may inform clinical assessment strategies.

Language: Английский

---

The role of VEGF in vascular dementia: impact of aging and cellular senescence

Biogerontology, Journal Year: 2025, Volume and Issue: 26(2)

Published: March 22, 2025

Language: Английский

---

Network Pharmacology and Experimental Validation Reveal Ganodermanontriol Modulates Pneumonia via TNF/NF‐κB/MAPKs Signaling Pathway

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: March 25, 2025

Ganoderma lucidum (Leyss. ex Fr.) Karst, commonly known as Lingzhi, has long been employed in traditional Chinese medicine for its medicinal properties, particularly alleviating respiratory issues like cough and asthma. Recognized both a therapeutic agent an edible supplement, Lingzhi is celebrated health-promoting benefits. Despite widespread use, the effectiveness of G. treating pneumonia not extensively studied, highlighting need further research. This research aimed to evaluate potential treatment uncover mechanisms behind effects, specifically examining how active constituents influence inflammatory pathways. The study utilized approaches such network pharmacology, bioinformatics, molecular docking, vivo experiments. High-performance liquid chromatography (HPLC) chromatography-mass spectrometry (LC-MS) analyses revealed eight triterpenoids lucidum, with ganodermanontriol being most prominent. Molecular docking studies anticipated interactions between these compounds target proteins, while experiments on pneumonia-induced rat models assessed efficacy ganodermanontriol. Additionally, HPLC LC-MS confirmed presence ethanol extract predominantly Network pharmacology identified key genes-including TNF, EGFR, ESR1, HIF1A, HSP90AA1, SRC-that played significant roles regulation In results demonstrated that mitigated lung tissue damage rats experimentally induced by reducing release mediators. Further mechanistic showed downregulated TNF-α inhibited NF-κB/MAPKs signaling These findings suggested holds promising anti-inflammatory targeting TNF/NF-κB/MAPKs pathway, offering novel approach.

Language: Английский

---

Green Synthesis and Characterization of ZnO Nanoparticles Using Crinum Asiaticum Leaf Extracts for Biomedical Applications

Luminescence, Journal Year: 2025, Volume and Issue: 40(4)

Published: April 1, 2025

ABSTRACT Zinc oxide nanoparticles are increasingly recognized for their applications in optics, electronics, food packaging, and biomedical research. This study investigates the green synthesis of ZnONPs using leaf extracts from Crinum asiaticum , a tropical plant. The synthesized were characterized UV–Vis spectroscopy, X‐ray diffraction, Fourier‐transform infrared scanning electron microscopy, atomic force particle size analysis. exhibited strong absorption peak at 399 nm hexagonal wurtzite structure. Increasing volume plant extract enhanced crystallinity, as evidenced by higher intensities, narrower full width half maximum, well‐defined diffraction peaks. FTIR analysis revealed functional groups interacting with ZnONPs, volumes introducing additional that improved nanoparticle stability, size, structural order. highlights potential an eco‐friendly sustainable approach ZnONP synthesis, underscoring importance optimization tailoring properties.

Language: Английский

---

Recent Perspectives on the Pharmacological, Nutraceutical, Functional, and Therapeutic Properties of Moringa oleifera Plant

Food Science & Nutrition, Journal Year: 2025, Volume and Issue: 13(4)

Published: April 1, 2025

ABSTRACT The “miracle tree,” Moringa oleifera , has gained so much attention because of its spectacular nutritional profile and potential health benefits, making it one the candidates for functional food product creation. benefits M. are presented here in this review alongside antioxidant conformation, bioactive constituents, macro‐ micronutrient conformation. is rapidly becoming a key effective component formulating healthy foodstuffs outstanding anti‐inflammatory, antimicrobial, antidiabetic, antioxidant, neuroprotective activities. Investigation into usage moringa products foods like dairy substitutes, powders, supplements, drinks, even snacks also part review. Notwithstanding auspicious there contests with development such as issues sensory perception, active ingredient constancy, budget constraints. Maintainable plant‐based demand across sphere pushing novelty industry. To improve current scalability suitability moringa‐based foods, concludes call additional investigation.

Language: Английский

---