Journal of Hematology & Oncology,
Journal Year:
2022,
Volume and Issue:
15(1)
Published: May 4, 2022
Abstract
Chromatin
has
distinct
three-dimensional
(3D)
architectures
important
in
key
biological
processes,
such
as
cell
cycle,
replication,
differentiation,
and
transcription
regulation.
In
turn,
aberrant
3D
structures
play
a
vital
role
developing
abnormalities
diseases
cancer.
This
review
discusses
chromatin
(topologically
associating
domain,
lamina-associated
enhancer–promoter
interactions)
corresponding
structural
protein
elements
mediating
interactions
[CCCTC-binding
factor,
polycomb
group
protein,
cohesin,
Brother
of
the
Regulator
Imprinted
Sites
(BORIS)
protein]
with
highlight
their
associations
We
also
summarise
recent
development
technologies
bioinformatics
approaches
to
study
gene
expression
regulation,
including
crosslinking
proximity
ligation
methods
bulk
population
(ChIA-PET
HiChIP)
or
single-molecule
resolution
(ChIA-drop),
other
than
ligation,
GAM,
SPRITE,
super-resolution
microscopy
techniques.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Feb. 17, 2023
Abstract
Hematologic
malignancies
are
one
of
the
most
common
cancers,
and
incidence
has
been
rising
in
recent
decades.
The
clinical
molecular
features
hematologic
highly
heterogenous,
some
incurable,
challenging
treatment,
prognosis
patients.
However,
hematopoiesis
oncogenesis
profoundly
affected
by
epigenetic
regulation.
Studies
have
found
that
methylation-related
mutations,
abnormal
methylation
profiles
DNA,
histone
deacetylase
expression
recurrent
leukemia
lymphoma.
Furthermore,
hypomethylating
agents
inhibitors
effective
to
treat
acute
myeloid
T-cell
lymphomas,
indicating
regulation
is
indispensable
oncogenesis.
Epigenetic
mainly
includes
DNA
modifications,
noncoding
RNA-mediated
targeting,
regulates
various
DNA-based
processes.
This
review
presents
role
writers,
readers,
erasers
methylation,
acetylation
malignancies.
In
addition,
this
provides
influence
microRNAs
long
RNAs
on
implication
targeted
treatment
discussed.
comprehensively
change
function
each
regulator
normal
oncogenic
innovative
epigenetic-targeted
practice.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(13)
Published: Jan. 21, 2023
Abstract
Hydrophobic
tagging
(HyT)
is
a
potential
therapeutic
strategy
for
targeted
protein
degradation
(TPD).
Norbornene
was
discovered
as
an
unprecedented
hydrophobic
tag
in
this
study
and
used
to
degrade
the
anaplastic
lymphoma
kinase
(ALK)
fusion
by
linking
it
ALK
inhibitors.
The
most
promising
degrader,
Hyt‐9
,
potently
reduced
levels
through
Hsp70
ubiquitin−proteasome
system
(UPS)
vitro
without
compensatory
upregulation
of
.
Furthermore,
exhibited
significant
tumor‐inhibiting
effect
vivo
with
moderate
oral
bioavailability.
More
importantly,
norbornene
can
also
be
intractable
enhancer
zeste
homolog
2
(EZH2)
when
tagged
EZH2
inhibitor
tazemetostat.
Thus,
discovery
novel
tags
shows
promise
future
development
TPD
technology.
Theranostics,
Journal Year:
2023,
Volume and Issue:
13(6), P. 1860 - 1875
Published: Jan. 1, 2023
Rationale:
The
role
of
histone
methylation
modifications
in
renal
disease,
particularly
sepsis-induced
acute
kidney
injury
(AKI),
remains
unclear.
This
study
aims
to
investigate
the
potential
involvement
methyltransferase
zeste
homolog
2
(EZH2)
AKI
and
its
impact
on
apoptosis
inflammation.
Methods:
We
first
examined
expression
EZH2
(LPS
injection)
mice
LPS-stimulated
tubular
epithelial
cells.
next
constructed
knockout
further
confirm
effects
inflammatory
response
AKI.
And
level
cells
can
be
reflected
by
detecting
chemokines
chemotaxis
macrophages.
Subsequently,
we
knocked-down
again
performed
Chromatin
Immunoprecipitation
sequencing
screen
out
target
genes
regulated
enrichment
pathway.
Then
confirmed
gene
regulatory
pathway
vivo
vitro
experiments.
Experimental
results
were
finally
using
another
model
(cecal
perforation
ligation).
Results:
found
that
was
upregulated
silencing
could
reduce
decreasing
showed
significantly
reduced
inflammation
macrophage
infiltration.
immunoprecipitation
polymerase
chain
reaction
identified
Sox9
as
a
EZH2.
enriched
promoter
Sox9.
Silencing
resulted
significant
increase
transcriptional
activation
Wnt/β-catenin
signaling
reversed
or
administering
inhibitor
icg001.
It
also
positively
β-catenin
downstream
pathway-related
genes.
Finally,
3-deazaneplanocin
A
alleviated
Conclusion:
Our
indicate
protect
function
relieving
inhibition
Sox9,
activating
pathway,
attenuating
interstitium.
These
highlight
therapeutic
value
targeting
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Sept. 2, 2024
Abstract
The
primary
reason
for
high
mortality
rates
among
cancer
patients
is
metastasis,
where
tumor
cells
migrate
through
the
bloodstream
from
original
site
to
other
parts
of
body.
Recent
advancements
in
technology
have
significantly
enhanced
our
comprehension
mechanisms
behind
bloodborne
spread
circulating
(CTCs).
One
critical
process,
DNA
methylation,
regulates
gene
expression
and
chromosome
stability,
thus
maintaining
dynamic
equilibrium
Global
hypomethylation
locus-specific
hypermethylation
are
examples
changes
methylation
patterns
that
pivotal
carcinogenesis.
This
comprehensive
review
first
provides
an
overview
various
processes
contribute
formation
CTCs,
including
epithelial-mesenchymal
transition
(EMT),
immune
surveillance,
colonization.
We
then
conduct
in-depth
analysis
how
modifications
within
CTCs
impact
each
these
stages
during
CTC
dissemination.
Furthermore,
we
explored
potential
clinical
implications
with
cancer.
By
understanding
epigenetic
modifications,
can
gain
insights
into
metastatic
process
identify
new
biomarkers
early
detection,
prognosis,
targeted
therapies.
aims
bridge
gap
between
basic
research
application,
highlighting
significance
context
metastasis
offering
avenues
improving
patient
outcomes.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 2, 2024
Abstract
Cancer
is
the
second
leading
cause
of
death
worldwide
and
disease
burden
expected
to
increase
globally
throughout
next
several
decades,
with
majority
cancer-related
deaths
occurring
in
metastatic
disease.
Cancers
exhibit
known
hallmarks
that
endow
them
increased
survival
proliferative
capacities,
frequently
as
a
result
de-stabilizing
mutations.
However,
genomic
features
resolve
clones
from
primary
tumors
are
not
yet
well-characterized,
no
mutational
landscape
has
been
identified
predictive
metastasis.
Further,
many
cancers
mutation
signature.
This
suggests
larger
role
for
non-mutational
genome
re-organization
promoting
cancer
evolution
dissemination.
In
this
review,
we
highlight
current
critical
needs
understanding
cell
state
transitions
clonal
selection
advantages
cells.
We
examine
links
between
epigenetic
states,
structure,
misregulation
tumor
suppressors
oncogenes,
discuss
how
recent
technologies
domain-scale
regulation
have
leveraged
more
complete
picture
oncogenic
potential.
