Biomaterials, Journal Year: 2023, Volume and Issue: 303, P. 122395 - 122395
Published: Nov. 15, 2023
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)
Published: May 22, 2023
Abstract Over decades, researchers have focused on the epigenetic control of DNA-templated processes. Histone modification, DNA methylation, chromatin remodeling, RNA and noncoding RNAs modulate many biological processes that are crucial to development cancers. Dysregulation epigenome drives aberrant transcriptional programs. A growing body evidence suggests mechanisms modification dysregulated in human cancers might be excellent targets for tumor treatment. Epigenetics has also been shown influence immunogenicity immune cells involved antitumor responses. Thus, application therapy cancer immunotherapy their combinations may important implications Here, we present an up-to-date thorough description how modifications cell responses microenvironment (TME) epigenetics internally modify TME. Additionally, highlight therapeutic potential targeting regulators immunotherapy. Harnessing complex interplay between immunology develop therapeutics combine thereof is challenging but could yield significant benefits. The purpose this review assist understanding impact TME, so better immunotherapies can developed.
Language: Английский
Citations
152
Drug Resistance Updates, Journal Year: 2023, Volume and Issue: 67, P. 100937 - 100937
Published: Feb. 2, 2023
Language: Английский
Citations
105
Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics, Journal Year: 2023, Volume and Issue: 32(2), P. 241 - 249
Published: Dec. 7, 2023
Breast cancer has surpassed lung to become the most common malignancy worldwide. The incidence rate and mortality of breast continue rise, which leads a great burden on public health. Circular RNAs (circRNAs), new class noncoding (ncRNAs), have been recognized as important oncogenes or suppressors in regulating initiation progression. In cancer, circRNAs significant roles tumorigenesis, recurrence multidrug resistance that are mediated by various mechanisms. Therefore, may serve promising targets therapeutic strategies for management. This study reviews recent studies about biosynthesis characteristics diagnosis, treatment prognosis evaluation, well value clinical applications biomarkers cancer. Understanding mechanisms function could help transform basic research into facilitate development novel circRNA-based treatment.
Language: Английский
Citations
57
Experimental Hematology and Oncology, Journal Year: 2023, Volume and Issue: 12(1)
Published: Oct. 12, 2023
Abstract Circular RNAs (circRNAs) are a class of covalently closed, endogenous ncRNAs. Most circRNAs derived from exonic or intronic sequences by precursor RNA back-splicing. Advanced high-throughput sequencing and experimental technologies have enabled the extensive identification characterization circRNAs, such as novel types biogenesis, tissue-specific cell-specific expression patterns, epigenetic regulation, translation potential, localization metabolism. Increasing evidence has revealed that participate in diverse cellular processes, their dysregulation is involved pathogenesis various diseases, particularly cancer. In this review, we systematically discuss databases, challenges for circRNA discovery, new insight into strategies used studies biomedical applications. Although recent advanced understanding knowledge approaches annotation, functional applications continuously needed to provide insights circRNAs. The emergence circRNA-based protein strategy will be promising direction field biomedicine.
Language: Английский
Citations
53
Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114698 - 114698
Published: April 13, 2023
With the rapid development of next-generation sequencing technology, several studies have shown that ncRNAs can act as competitive endogenous RNAs (ceRNAs) and are involved in various biological processes, such proliferation, differentiation, apoptosis, migration breast cancer (BC) cells, plays an important role BC progression a molecular target for its diagnosis, treatment, prognosis, differentiation subtypes age groups patients. Based on description ceRNA-related functions, this study screened sorted analysis experimental verification conclusions BC-related ceRNAs found mediated ceRNA networks promote by promoting expression genes related to drug resistance, inducing production epithelial-mesenchymal transition (EMT) metastasis activating cancer-related signaling pathways.
Language: Английский
Citations
42
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Jan. 3, 2024
Abstract Exosomes are nanoscale extracellular vesicles secreted by cells and enclosed a lipid bilayer membrane containing various biologically active cargoes such as proteins, lipids, nucleic acids. Engineered exosomes generated through genetic modification of parent show promise drug delivery vehicles, they have been demonstrated to great therapeutic potential for treating cancer, cardiovascular, neurological, immune diseases, but systematic knowledge is lacking regarding optimization loading assessment efficacy. This review summarizes current approaches engineering evaluating their effects, techniques assessing exosome release kinetics, cell targeting, biodistribution, pharmacokinetics, outcomes critically examined. Additionally, this synthesizes the latest applications in clinical translation. The compiled provides framework rational design rigorous therapeutics. Continued advancement robust characterization methods reporting standards will accelerate development technologies pave way studies. Graphical
Language: Английский
Citations
40
Nature reviews. Cancer, Journal Year: 2024, Volume and Issue: 24(9), P. 597 - 613
Published: July 29, 2024
Language: Английский
Citations
40
Small, Journal Year: 2024, Volume and Issue: 20(30)
Published: March 5, 2024
Abstract Gene therapy uses modern molecular biology methods to repair disease‐causing genes. As a burgeoning therapeutic, it has been widely applied for cancer therapy. Since 1989, there have numerous clinical gene cases worldwide. However, few are successful. The main challenge of is the lack efficient and safe vectors. Although viral vectors show high transfection efficiency, their application still limited by immune rejection packaging capacity. Therefore, development non‐viral overwhelming. Nanoplatform‐based become hotspot in reasons mainly as follows. 1) Non‐viral can be engineered uptaken specific types cells or tissues, providing effective targeting capability. 2) protect goods that need delivered from degradation. 3) Nanoparticles transport large‐sized cargo such CRISPR/Cas9 plasmids nucleoprotein complexes. 4) highly biosafe, they not mutagenic themselves compared 5) easy scale preparation, which conducive conversion application. Here, an overview categories nanoplatform‐based vectors, limitations on development, applications
Language: Английский
Citations
17
Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)
Published: Jan. 17, 2025
Circular RNAs (circRNAs) have garnered substantial attention due to their distinctive circular structure and gene regulatory functions, establishing them as a significant class of functional non-coding in eukaryotes. Studies demonstrated that circRNAs can interact with RNA-binding proteins (RBPs), which play crucial roles tumorigenesis, metastasis, drug response cancer by influencing expression altering the processes tumor initiation progression. This review aims summarize recent advances research on circRNA-protein interactions (CPIs) discuss functions mode action CPIs at various stages expression, including transcription, splicing, translation, post-translational modifications context cancer. Additionally, we explore role resistance gain deeper understanding potential applications development new anti-cancer therapeutic approaches.
Language: Английский
Citations
2
Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Language: Английский
Citations
2