Journal of Translational Medicine,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: June 12, 2024
Intravitreal
injections
of
angiogenesis
inhibitors
have
proved
efficacious
in
the
majority
patients
with
ocular
angiogenesis.
However,
one-fourth
all
treated
fail
to
derive
benefits
from
intravitreal
injections.
tRNA-derived
small
RNA
(tsRNA)
emerges
as
a
crucial
class
non-coding
molecules,
orchestrating
key
roles
progression
human
diseases
by
modulating
multiple
targets.
Through
our
prior
sequencing
analyses
and
bioinformatics
predictions,
tRNA-Cys-5-0007
has
shown
potential
regulator
This
study
endeavors
elucidate
precise
role
context
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: July 5, 2024
Abstract
Diabetic
wounds
are
characterized
by
incomplete
healing
and
delayed
healing,
resulting
in
a
considerable
global
health
care
burden.
Exosomes
lipid
bilayer
structures
secreted
nearly
all
cells
express
characteristic
conserved
proteins
parent
cell-associated
proteins.
harbor
diverse
range
of
biologically
active
macromolecules
small
molecules
that
can
act
as
messengers
between
different
cells,
triggering
functional
changes
recipient
thus
endowing
the
ability
to
cure
various
diseases,
including
diabetic
wounds.
accelerate
wound
regulating
cellular
function,
inhibiting
oxidative
stress
damage,
suppressing
inflammatory
response,
promoting
vascular
regeneration,
accelerating
epithelial
facilitating
collagen
remodeling,
reducing
scarring.
from
tissues
or
potentially
possess
functions
varying
levels
promote
healing.
For
example,
mesenchymal
stem
cell-derived
exosomes
(MSC-exos)
have
favorable
potential
field
due
their
superior
stability,
permeability,
biocompatibility,
immunomodulatory
properties.
Exosomes,
which
derived
skin
components,
modulate
inflammation
regeneration
key
turn
promotes
Therefore,
this
review
mainly
emphasizes
roles
mechanisms
sources,
represented
MSCs
improving
A
deeper
understanding
therapeutic
will
yield
promising
candidates
perspectives
for
management.
Molecular Cancer,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: Jan. 13, 2025
This
review
highlights
recent
progress
in
exosome-based
drug
delivery
for
cancer
therapy,
covering
exosome
biogenesis,
cargo
selection
mechanisms,
and
their
application
across
multiple
types.
As
small
extracellular
vesicles,
exosomes
exhibit
high
biocompatibility
low
immunogenicity,
making
them
ideal
vehicles
capable
of
efficiently
targeting
cells,
minimizing
off-target
damage
side
effects.
aims
to
explore
the
potential
with
a
focus
on
applications
chemotherapy,
gene
immunomodulation.
Additionally,
challenges
related
production
standardization
are
analyzed,
highlighting
importance
addressing
these
issues
clinical
application.
In
conclusion,
systems
offer
promising
future
therapies.
Further
research
should
aim
enhance
efficiency
facilitate
translation,
paving
way
innovative
treatment
strategies.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(14), P. 7715 - 7715
Published: July 14, 2024
Exosomes
are
small
vesicles
containing
proteins,
nucleic
acids,
and
biological
lipids,
which
responsible
for
intercellular
communication.
Studies
have
shown
that
exosomes
can
be
utilized
as
effective
drug
delivery
vehicles
to
accurately
deliver
therapeutic
substances
target
tissues,
enhancing
effects
reducing
side
effects.
Mesenchymal
stem
cells
(MSCs)
a
class
of
widely
used
tissue
engineering,
regenerative
medicine,
immunotherapy.
derived
from
MSCs
special
immunomodulatory
functions,
low
immunogenicity,
the
ability
penetrate
tumor
high
yield,
expected
engineered
into
efficient
systems.
Despite
promising
promise
MSC-derived
exosomes,
exploring
their
optimal
preparation
methods,
drug-loading
modalities,
potential
remains
challenging.
Therefore,
this
article
reviews
related
characteristics,
application,
risks
systems
in
order
find
breakthroughs.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(6), P. 709 - 709
Published: May 24, 2024
Of
all
the
numerous
nanosized
extracellular
vesicles
released
by
a
cell,
endosomal-originated
exosomes
are
increasingly
recognized
as
potential
therapeutics,
owing
to
their
inherent
stability,
low
immunogenicity,
and
targeted
delivery
capabilities.
This
review
critically
evaluates
transformative
of
exosome-based
modalities
across
pharmaceutical
precision
medicine
landscapes.
Because
precise
biomolecular
cargo
delivery,
posited
ideal
candidates
in
drug
enhancing
regenerative
strategies,
advancing
diagnostic
technologies.
Despite
significant
market
growth
projections
exosome
therapy,
its
utilization
is
encumbered
substantial
scientific
regulatory
challenges.
These
include
lack
universally
accepted
protocols
for
isolation
complexities
associated
with
navigating
environment,
particularly
guidelines
set
forth
U.S.
Food
Drug
Administration
(FDA).
presents
comprehensive
overview
current
research
trajectories
aimed
at
addressing
these
impediments
discusses
prospective
advancements
that
could
substantiate
clinical
translation
exosomal
therapies.
By
providing
analysis
both
capabilities
hurdles
therapeutic
applications,
this
article
aims
inform
direct
future
paradigms,
thereby
fostering
integration
systems
into
mainstream
practice.
Vaccines,
Journal Year:
2024,
Volume and Issue:
12(2), P. 200 - 200
Published: Feb. 15, 2024
Nucleic
acid
delivery
through
extracellular
vesicles
(EVs)
is
a
well-preserved
evolutionary
mechanism
in
all
life
kingdoms
including
eukaryotes,
prokaryotes,
and
plants.
EVs
naturally
allow
horizontal
transfer
of
native
as
well
exogenous
functional
mRNAs,
which
once
incorporated
are
protected
from
enzymatic
degradation.
This
observation
has
prompted
researchers
to
investigate
whether
different
sources,
plants,
could
be
used
for
vaccine
delivery.
Several
studies
using
human
or
bacterial
expressing
mRNA
recombinant
SARS-CoV-2
proteins
showed
induction
humoral
cell
mediated
immune
response.
Moreover,
EV-based
vaccines
presenting
the
natural
configuration
viral
antigens
have
demonstrated
advantages
conferring
long-lasting
immunization
lower
toxicity
than
synthetic
nanoparticles.
Edible
plant-derived
were
shown
an
alternative
delivery,
especially
via
oral
administration.
obtained
orange
juice
(oEVs)
loaded
with
mRNAs
their
cargo
degradation,
stable
at
room
temperature
one
year,
able
trigger
response
mice.
Lyophilized
oEVs
containing
S1
administered
rats
gavage
induced
specific
generation
blocking
antibodies,
IgA
Th1
lymphocyte
activation.
In
conclusion,
mRNA-containing
developing
new
due
optimal
mucosal
absorption,
resistance
stress
conditions,
ability
stimulate
cellular
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 3657 - 3675
Published: April 1, 2024
Abstract:
Exosomes
are
extracellular
vesicles
that
originate
from
various
cells
and
mediate
intercellular
communication,
altering
the
behavior
or
fate
of
recipient
cells.
They
carry
diverse
macromolecules,
such
as
lipids,
proteins,
carbohydrates,
nucleic
acids.
Environmental
stressors
can
change
exosomal
contents
many
cells,
making
them
useful
for
diagnosing
chronic
disorders,
especially
neurodegenerative,
cardiovascular,
cancerous,
diabetic
diseases.
Moreover,
exosomes
be
engineered
therapeutic
agents
to
modulate
disease
processes.
State-of-art
techniques
employed
separate
including
ultracentrifugation,
size-exclusion
chromatography
immunoaffinity.
However,
modern
technologies
aqueous
two-phase
system
well
microfluidics
gaining
attention
in
recent
years.
The
article
highlighted
composition,
biogenesis,
implications
exosomes,
standard
novel
methods
isolating
applying
biomarkers
cargo
carriers.
Keywords:
Exosomes,
vesicles,
biomarkers,
carriers,
separation
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 1, 2024
Exosomes
play
a
crucial
role
in
various
biological
processes,
such
as
human
development,
immune
responses,
and
disease
occurrence.
The
membrane
proteins
on
exosomes
are
pivotal
factors
for
their
functionality.
Currently,
numerous
have
been
identified
exosome
membranes,
participating
intercellular
communication,
mediating
target
cell
recognition,
regulating
processes.
Furthermore,
from
derived
cancer
cells
can
serve
relevant
biomarkers
early
diagnosis.
This
article
provides
comprehensive
review
of
the
composition
diverse
functions
organism's
Through
in-depth
exploration
proteins,
it
is
expected
to
offer
essential
foundations
future
development
novel
biomedical
diagnostics
therapies.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 25, 2024
The
tumor
microenvironment
(TME)
plays
a
crucial
role
in
cancer
progression
and
immune
evasion,
partially
mediated
by
the
activity
of
TME-derived
exosomes.
These
extracellular
vesicles
are
pivotal
shaping
responses
through
transfer
proteins,
lipids,
nucleic
acids
between
cells,
facilitating
complex
interplay
that
promotes
growth
metastasis.
This
review
delves
into
dual
roles
exosomes
TME,
highlighting
both
their
immunosuppressive
functions
emerging
therapeutic
potential.
Exosomes
can
inhibit
T
cell
function
promote
escape
carrying
immune-modulatory
molecules,
such
as
PD-L1,
yet
they
also
hold
promise
for
therapy
vehicles
delivering
antigens
costimulatory
signals.
Additionally,
discusses
intricate
crosstalk
among
various
types
within
influencing
to
immunotherapies.
Moreover,
this
highlights
current
challenges
future
directions.
Collectively,
elucidating
detailed
mechanisms
which
mediate
offers
promising
avenue
revolutionizing
treatment.
Understanding
these
interactions
allows
development
targeted
therapies
manipulate
exosomal
pathways
enhance
system's
response
tumors.
