Inflammation and cancer: molecular mechanisms and clinical consequences

Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15

Published: March 17, 2025

Inflammation, a hallmark of cancer, has been associated with tumor progression, transition into malignant phenotype and efficacy anticancer treatments in cancer. It affects all stages from the initiation carcinogenesis to metastasis. Chronic inflammation induces immunosup-pression, providing an environment conducive carcinogenesis, whereas acute antitumor immune response, leading suppression. Solid tumors have inflammatory microenvironment (TME) containing cancer cells, stromal soluble molecules, which plays key role progression therapy response. Both cells TME are highly plastic constantly change their phenotypic functional properties. Cancer-associated inflammation, majority consists innate important cell plasticity, development drug resistance. Today, combined used advanced technologies, such as single-cell RNA sequencing spatial molecular imaging analysis, pathways linking chronic largely elucidated. In this review article, we highlighted cellular mechanisms involved cancer-associated its effects on treatment We also comprehensively setting GI cancers.

Language: Английский

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Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Abstract Targeted regulation of pyroptosis to modulate the immune landscape has emerged as a novel design strategy for cancer immunotherapy and anti‐inflammatory therapy. However, acts double‐edged sword, making it important optimize strategies functional materials appropriately activate effective disease treatment. This paper summarizes discusses structure, pore formation, molecular mechanisms “executor” Gasdermins, well events preceding following these processes. Subsequently, focus is on reviewing that directly regulate Gasdermin formation target those indirectly before after control activity. Finally, advantages, disadvantages, future prospects designing such are provided, aiming facilitate precise design, pharmacological investigation, clinical translation pyroptosis‐related materials.

Language: Английский

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The multifaceted role of Sestrin 3 (SESN3) in oxidative stress, inflammation and tumorigenesis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, Journal Year: 2025, Volume and Issue: unknown, P. 119938 - 119938

Published: March 1, 2025

Language: Английский

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Probing into the chemopreventive properties of synthetic 1,3,6-tri-O-galloyl-α-D-glucose (α-TGG) against glioblastoma and triple-negative breast cancer-derived cell models

Current Research in Pharmacology and Drug Discovery, Journal Year: 2025, Volume and Issue: 8, P. 100219 - 100219

Published: Jan. 1, 2025

Inflammation plays a significant role in cancer progression. Chemopreventive strategies against cellular response to pro-inflammatory cues may therefore contribute inhibit the acquisition of an invasive phenotype. 1,3,6-Tri-O-Galloyl-β-D-Glucose (β-TGG) is type gallotannin naturally found plants like Paeonia lactiflora and Terminalia chebula. Unfortunately, overall yields β-TGG extraction require complex purification protocols from plant sources are relatively low. Here, new synthetic α-anomer TGG (α-TGG) was characterized for anti-inflammatory anticancer biological properties. In vitro epithelial-to-mesenchymal transition (EMT) cues, triggered by phorbol 12-myristate 13-acetate (PMA), concanavalin A (ConA), tumor necrosis factor (TNF) α, transforming growth (TGF) β, were used screen α-TGG two highly aggressive human cell models, namely U87 glioblastoma MDA-MB-231 triple-negative breast (TNBC)-derived cells. dose-dependently inhibited ConA-mediated activation latent matrix metalloproteinase pro-MMP-2 into its active MMP-2 form as well ConA- PMA-mediated cyclooxygenase (COX)-2 expression, biomarkers inflammation, MDA-MB-231, PMA- TNFα-mediated induction pro-MMP-9, marker inflammation Finally, both lines, further TGFβ-induced chemotaxis, Smad2 phosphorylation Snail crucial upstream signaling pathway downstream associated with EMT. Collectively, we confirm that retained potent anti-invasive pharmacological properties which support chemopreventive potential.

Language: Английский

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High‐Density Arrangement of Biomimetic Plasmonic Nanoprobes Guided by DNA Nanoroller based Cleaving‐Rolling Process for SERS Sensing Analysis

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(44)

Published: Aug. 18, 2024

Abstract DNA walker nanomachines are in fast development for biosensing, medical diagnostics, and food safety monitoring. For practical application, the issues of slow dynamics low operational efficiency hinder its widespread application. Inspired by high agricultural cooperative machinery, a unique cleaving‐rolling‐assembly integrated nanodevice (CRAIN) is constructed high‐performance detection various biomolecules. In design, nanotubes introduced as building loaders to engineer polyoriented walking nanorollers with blocked DNAzyme‐based strands thus increase reaction direction local concentration. Through target‐specific recognition, activated can autonomously progressively cleave roll along directional hairpin tracks on gold substrate, significantly accelerating rate. Moreover, using nucleic acid‐encoded urchin‐shaped multispike gold‐silver composite nanospheres (nMGSs) SERS‐enhanced probes, engineered assembly nMGSs probes induced cleaving‐rolling process promotes formation high‐density hotspot domains, further improving sensitivity. With rational CRAIN system be extended perform highly sensitive analyses analytes, such microRNA‐21, butyrylcholinesterase activity organophosphorus pesticides. This strategy provide new perspectives clinical diagnosis, biomedical engineering, environmental science.

Language: Английский

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The causal effect of atopic dermatitis on lung cancer: A Mendelian randomization study

Skin Research and Technology, Journal Year: 2024, Volume and Issue: 30(7)

Published: July 1, 2024

Abstract Background Growing evidence has shown that atopic dermatitis (AD) may decrease lung cancer (LC) risk. However, the causality between two diseases is inconsistent and controversial. Therefore, we explored causal relationship AD different histological subtypes of LC by using Mendelian randomization (MR) method. Materials methods We conducted MR study based on summary statistics from genome‐wide association studies (GWAS) (10,788 cases 30,047 controls) (29,266 56,450 controls). Instrumental variables (IVs) were obtained after removing SNPs associated with potential confounders. employed inverse‐variance weighted (IVW), MR‐Egger, median to pool estimates, performed a comprehensive sensitivity analysis. Results The results IVW method suggested risk developing adenocarcinoma (LUAD) (OR = 0.91, 95% CI: 0.85‐0.97, P 0.007). Moreover, no was identified overall 0.96, 0.91–1.01, 0.101), squamous cell carcinoma (LUSC) 1.04, 0.96–1.036, 0.324), small (SCLC) 0.95, 0.82–1.10, 0.512). A test showed robustness our results. Conclusion present indicates LUAD in European population, which needs additional investigations identify molecular mechanisms.

Language: Английский

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Thrombotic events associated with immune checkpoint inhibitors and novel antithrombotic strategies to mitigate bleeding risk

Blood Reviews, Journal Year: 2024, Volume and Issue: 67, P. 101220 - 101220

Published: June 7, 2024

Language: Английский

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Naples Prognostic Score: A Novel Predictor of Survival in Patients with Triple-Negative Breast Cancer

Journal of Inflammation Research, Journal Year: 2024, Volume and Issue: Volume 17, P. 5253 - 5269

Published: Aug. 1, 2024

This study investigated the correlation between Naples prognostic score (NPS), clinicopathological traits, and postoperative prognoses of patients with triple-negative breast cancer (TNBC). Based on NPS, a predictive nomogram was developed to estimate long-term survival probabilities TNBC post-surgery.

Language: Английский

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Multifaceted Properties of Usnic Acid in Disrupting Cancer Hallmarks

Biomedicines, Journal Year: 2024, Volume and Issue: 12(10), P. 2199 - 2199

Published: Sept. 26, 2024

Cancer, a complex group of diseases marked by uncontrolled cell growth and invasive behavior, is characterized distinct hallmarks acquired during tumor development. These hallmarks, first proposed Douglas Hanahan Robert Weinberg in 2000, provide framework for understanding cancer's complexity. Targeting them key strategy cancer therapy. It includes inhibiting abnormal signaling, reactivating suppressors, preventing invasion metastasis, angiogenesis, limiting replicative immortality, modulating the immune system, inducing apoptosis, addressing genome instability regulating cellular energetics. Usnic acid (UA) natural compound found lichens that has been explored as cytotoxic agent against cells different origins. Although exact mechanisms remain incompletely understood, UA presents promising therapeutic intervention. Understanding its impact on provides valuable insights into potential developing targeted multifaceted therapies. This article explores activity context disrupting origins based recent articles emphasize molecular this activity.

Language: Английский

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Prognostic Study of Inflammatory Markers in Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy

Cancer Management and Research, Journal Year: 2024, Volume and Issue: Volume 16, P. 1321 - 1328

Published: Sept. 1, 2024

Inflammatory markers in the blood have been linked to tumor prognosis, but their specific prognostic significance nasopharyngeal carcinoma (NPC) patients undergoing intensity-modulated radiotherapy (IMRT) is not well established. This study aims evaluate value of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), and lymphocyte-to-monocyte (LMR) this patient population.

Language: Английский

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