Nanomaterials, Journal Year: 2024, Volume and Issue: 14(23), P. 1904 - 1904
Published: Nov. 27, 2024
The field of optical nanomaterials stands at the forefront technological innovation, driving advancements across a spectrum scientific disciplines and industries [...]
Language: Английский
Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14
Published: May 28, 2024
Triple-negative breast cancer (TNBC) poses significant challenges in oncology due to its aggressive nature, limited treatment options, and poorer prognosis compared other subtypes. This comprehensive review examines the therapeutic diagnostic landscape of TNBC, highlighting current strategies, emerging therapies, future directions. Targeted including PARP inhibitors, immune checkpoint EGFR hold promise for personalized approaches. Challenges identifying novel targets, exploring combination developing predictive biomarkers must be addressed optimize targeted therapy TNBC. Immunotherapy represents a transformative approach TNBC treatment, yet biomarker identification, overcoming resistance persist. Precision medicine approaches offer opportunities tailored based on tumor biology, but integration multi-omics data clinical implementation present requiring innovative solutions. Despite these challenges, ongoing research efforts collaborative initiatives hope improving outcomes advancing strategies By addressing complexities biology effective approaches, treatments can realized, ultimately enhancing lives patients. Continued research, trials, interdisciplinary collaborations are essential realizing this vision making meaningful progress management.
Language: Английский
Citations
21
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 5, 2025
Abstract Lateral flow assays (LFAs) are widely applicable in clinical point‐of‐care testing (POCT) due to their unique advantages such as simplicity, rapidity, and cost‐effectiveness. However, sensitivity is often constrained by the background autofluorescence of biological sample, self‐matrix, or readout technique, thereby leading overlooking trace amounts biomarkers present early disease. In recent years, various nanomaterials‐based methods have been developed address this issue, including time‐gated wavelength‐differentiated strategy external modulated for separation minimize interference from samples. This review provides a comprehensive overview low‐background luminescent nanoparticles (LBLNPs)‐enhanced LFA systems, focusing on analyzing underlying mechanism these nanomaterials improving accuracy LFAs platform diagnosis. Representative examples selected demonstrate potential detecting disease‐associated samples blood, urine, saliva et al. Finally, unresolved challenges future development prospects briefly discussed.
Language: Английский
Citations
1
Biosensors, Journal Year: 2025, Volume and Issue: 15(1), P. 54 - 54
Published: Jan. 16, 2025
Lateral flow immunoassays (LFIAs) are widely used for their low cost, simplicity, and rapid results; however, enhancing reliability requires the meticulous selection of ligands nanoparticles (NPs). SiO2@QD@SiO2 (QD2) nanoparticles, which consist quantum dots (QDs) embedded in a silica (SiO2) core surrounded by an outer SiO2 shell, exhibit significantly higher fluorescence intensity (FI) compared to single QDs. In this study, we prepared QD2@PEG@Aptamer, aptamer conjugated with QD2 using succinimidyl-[(N-maleimidopropionamido)-hexaethyleneglycol]ester, is 130 times brighter than QDs, detecting carbohydrate antigen (CA) 19-9 through LFIA. For LFIA optimization, determined optimal conditions as 1.0:2.0 × 10−2 ratio polyethylene glycol (PEG) adjusting amounts PEG aptamer, phosphate-buffered saline containing 0.5% Tween® 20 developing solution, 0.15 μg NPs setting NP weight during development. Under these conditions, QD2@PEG@Aptamer selectively detected CA19-9, achieving detection limit 1.74 mg·mL−1. Moreover, FI remained stable 10 days after detection. These results highlight potential conjugation technology reliable versatile sensing platform various diagnostic applications.
Language: Английский
Citations
1
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 267, P. 116818 - 116818
Published: Sept. 28, 2024
Language: Английский
Citations
4
Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 10, 2025
Ferroptosis is a novel mode of iron-dependent non-apoptotic cell death that occurs mainly due to excessive accumulation lipid peroxides. Numerous studies in recent years have shown ferroptosis plays vital role the organism and has important interactions with immune cells. been great potential tumour therapy through studying its mechanism action. In addition, major many types cells can potently suppress tumourigenesis metastasis, provide basis for treatment malignant diseases become therapeutic modality antitumour immunity clinic. Current immunotherapy combination other conventional oncological modalities not well elaborated. this paper, we discuss connection their mediated order better theoretical new thinking about immunity.
Language: Английский
Citations
0
Journal of Nanoparticle Research, Journal Year: 2025, Volume and Issue: 27(4)
Published: April 1, 2025
Language: Английский
Citations
0
Sensors and Actuators B Chemical, Journal Year: 2025, Volume and Issue: unknown, P. 137832 - 137832
Published: April 1, 2025
Language: Английский
Citations
0
Discover Nano, Journal Year: 2025, Volume and Issue: 20(1)
Published: April 24, 2025
Cancer treatments often exploit oxidative stress to selectively kill tumour cells by disrupting their lipid peroxidation membranes and inhibiting antioxidant enzymes. However, plays a dual role in cancer progression, acting as both promoter suppressor. Balancing through therapy remains challenge, excessive activity may compromise the efficacy of chemotherapy radiotherapy. This review explores antioxidants mitigating while maintaining treatment efficacy. It highlights recent advancements nanotechnology-based targeted delivery optimize therapeutic outcomes. A comprehensive literature was conducted using reputable databases, including PubMed, Scopus, Web Science, ScienceDirect. The search focused on publications from past five years (2020-2025), supplemented relevant studies earlier years. Keywords such "antioxidants," "lipid peroxidation," "nanotechnology therapy," "oxidative stress" were utilized. Relevant articles critically analysed, graphical illustrations created. Emerging evidence suggests that nanoparticles, liposomes, polymeric metal-organic frameworks, others, can effectively encapsulate control release minimizing systemic toxicity. Stimuli-responsive carriers with tumour-specific targeting mechanisms further enhance delivery. Studies indicate these strategies help preserve normal cells, mitigate stress-related damage, improve challenges bioavailability, stability, potential interactions standard therapies remain. Integrating nanotechnology antioxidant-based interventions presents promising approach for optimizing therapy. Future research should focus refining modulation strategies, assessing profiles during treatment, employing biomarkers determine optimal dosing. balanced use adverse effects.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(29), P. 38243 - 38251
Published: July 9, 2024
Development of efficient portable sensors for accurately detecting biomarkers is crucial early disease diagnosis, yet remains a significant challenge. To address this need, we introduce the enhanced luminescence lateral-flow assay, which leverages highly luminescent upconverting nanoparticles (UCNPs) alongside reader and smartphone app. The sensor's efficiency versatility were shown kidney health monitoring as proof concept. We engineered Er
Language: Английский
Citations
3
Nanotechnology in the life sciences, Journal Year: 2025, Volume and Issue: unknown, P. 183 - 202
Published: Jan. 1, 2025
Language: Английский
Citations
0