Comprehensive prediction of immune microenvironment and hot and cold tumor differentiation in cutaneous melanoma based on necroptosis-related lncRNA DOI Creative Commons
Miao Zhang,

Lushan Yang,

Yizhi Wang

et al.

Scientific Reports, Journal Year: 2023, Volume and Issue: 13(1)

Published: May 5, 2023

Abstract As per research, causing cancer cells to necroptosis might be used as a therapy combat drug susceptibility. Long non-coding RNA (lncRNA) modulates the process in Skin Cutaneous Melanoma (SKCM), even though precise mechanism by which it does so has yet been unknown. sequencing and clinical evidence of SKCM patients were accessed from The Cancer Genome Atlas database, normal skin tissue data was available Genotype-Tissue Expression database. Person correlation analysis, differential screening, univariate Cox regression successively utilized identify necroptosis-related hub lncRNAs. Following this, we adopt least absolute shrinkage selection operator analysis construct risk model. model evaluated on various characteristics using many integrated approaches ensure generated accurate predictions. Through score comparisons consistent cluster sorted either high-risk or low-risk subgroups well distinct clusters. Finally, effect immune microenvironment, m7G methylation, viable anti-cancer drugs groups potential clusters further detail. Included USP30-AS1, LINC01711, LINC00520, NRIR, BASP1-AS1, LINC02178, 6 lncRNAs novel prediction with excellent accuracy sensitivity, not influenced confounding factors. Immune-related, necroptosis, apoptosis pathways enhanced structure, shown Gene Set Enrichment Analysis findings. TME score, factors, checkpoint-related genes, methylation-related sensitivity differed significantly between groups. Cluster 2 identified hot tumor better response therapeutic effect. Our study may provide biomarkers for predicting prognosis personalized based cold classification.

Language: Английский

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives DOI Creative Commons

Xiaoqi Mao,

Jin Xu, Wei Wang

et al.

Molecular Cancer, Journal Year: 2021, Volume and Issue: 20(1)

Published: Oct. 11, 2021

Abstract Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of tumor microenvironment (TME). Through multiple pathways, activated CAFs can promote growth, angiogenesis, invasion metastasis, along extracellular matrix (ECM) remodeling even chemoresistance. Numerous previous studies have confirmed critical role interaction between cells in tumorigenesis development. However, recently, mutual effects immune (TIME) been identified as another key factor promoting progression. The TIME mainly consists distinct populations islets is highly associated antitumor immunological state TME. interact tumor-infiltrating well other within via secretion various cytokines, growth factors, chemokines, exosomes effector molecules, consequently shaping an immunosuppressive TME that enables cancer to evade surveillance system. In-depth interactions, particularly complicated mechanisms connecting cells, might provide novel strategies for subsequent targeted immunotherapies. Herein, we shed light on recent advances regarding direct indirect crosstalk infiltrating further summarize possible immunoinhibitory induced by In addition, present current related CAF-targeting immunotherapies briefly describe some future perspectives CAF research end.

Language: Английский

Citations

1453
Machine learning-based integration develops an immune-derived lncRNA signature for improving outcomes in colorectal cancer DOI Creative Commons
Zaoqu Liu, Long Liu, Siyuan Weng

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Feb. 10, 2022

Long noncoding RNAs (lncRNAs) are recently implicated in modifying immunology colorectal cancer (CRC). Nevertheless, the clinical significance of immune-related lncRNAs remains largely unexplored. In this study, we develope a machine learning-based integrative procedure for constructing consensus lncRNA signature (IRLS). IRLS is an independent risk factor overall survival and displays stable powerful performance, but only demonstrates limited predictive value relapse-free survival. Additionally, possesses distinctly superior accuracy than traditional variables, molecular features, 109 published signatures. Besides, high-risk group sensitive to fluorouracil-based adjuvant chemotherapy, while low-risk benefits more from bevacizumab. Notably, abundant lymphocyte infiltration, high expression CD8A PD-L1, response pembrolizumab. Taken together, could serve as robust promising tool improve outcomes individual CRC patients.

Language: Английский

Citations

454
Modulation of the tumor microenvironment and mechanism of immunotherapy-based drug resistance in breast cancer DOI Creative Commons
Moumita Kundu, Ramesh Butti, Venketesh K. Panda

et al.

Molecular Cancer, Journal Year: 2024, Volume and Issue: 23(1)

Published: May 7, 2024

Abstract Breast cancer, the most frequent female malignancy, is often curable when detected at an early stage. The treatment of metastatic breast cancer more challenging and may be unresponsive to conventional therapy. Immunotherapy crucial for treating but its resistance a major limitation. tumor microenvironment (TME) vital in modulating immunotherapy response. Various microenvironmental components, such as cancer-associated fibroblasts (CAFs), tumor-associated macrophages (TAMs), myeloid-derived suppressor cells (MDSCs), are involved TME modulation cause resistance. This review highlights role stromal microenvironment, including involvement CAF-TAM interaction, alteration metabolism leading failure, other latest strategies, high throughput genomic screening, single-cell spatial omics techniques identifying immune genes regulating emphasizes therapeutic approach overcome through CAF reprogramming, TAM polarization, metabolism, alterations.

Language: Английский

Citations

50
lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment DOI Creative Commons
Xin Jin, Wei Du, Wentao Huang

et al.

Molecular Therapy — Nucleic Acids, Journal Year: 2021, Volume and Issue: 25, P. 613 - 637

Published: Aug. 19, 2021

Breast cancer is a malignant tumor that has high mortality rate and mostly occurs in women. Although significant progress been made the implementation of personalized treatment strategies for molecular subtypes breast cancer, therapeutic response often not satisfactory. Studies have reported long non-coding RNAs (lncRNAs) are abnormally expressed closely related to occurrence development cancer. In addition, tissue cell-type specificity makes lncRNAs particularly attractive as diagnostic biomarkers, prognostic factors, specific targets. Therefore, an in-depth understanding regulatory mechanisms essential developing new strategies. this review, we systematically elucidate general characteristics, potential mechanisms, targeted therapy discuss emerging functions Additionally, also highlight advantages challenges using biomarkers diagnosis or targets drug resistance present future perspectives clinical practice.

Language: Английский

Citations

81
Exosomal long non-coding RNAs in cancer: Interplay, modulation, and therapeutic avenues DOI Creative Commons
Rahaba Marima, Afra Basera, Thabiso Victor Miya

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(3), P. 887 - 900

Published: April 4, 2024

In the intricate field of cancer biology, researchers are increasingly intrigued by emerging role exosomal long non-coding RNAs (lncRNAs) due to their multifaceted interactions, complex modulation mechanisms, and potential therapeutic applications. These lncRNAs, carried within extracellular vesicles, play a vital partin tumorigenesis disease progression facilitating communication networks between tumor cells local microenvironment, making them an ideal candidates for use in liquid biopsy approach. However, lncRNAs remain understudied area, especially biology. Therefore this review aims comprehensively explore dynamic interplay various cellular components, including interactions with tumor-stroma, immune modulation, drug resistance mechanisms. Understanding regulatory functions these processes can potentially unveil novel diagnostic markers targets cancer. Additionally, emergence RNA-based therapeutics presents exciting opportunities targeting offering innovative strategies combat improve treatment outcomes. Thus, provides insights into current understanding highlighting crucial roles, evolving landscape interventions. Furthermore, we have also discussed advantage exosomes as carriers development personalized targeted therapy patients.

Language: Английский

Citations

15
Identification of ferroptosis-related lncRNAs for predicting prognosis and immunotherapy response in non-small cell lung cancer DOI
Lin Yuan,

Shengguo Sun,

Qinhu Zhang

et al.

Future Generation Computer Systems, Journal Year: 2024, Volume and Issue: 159, P. 204 - 220

Published: May 18, 2024

Language: Английский

Citations

13
Connecting the Dots: LncRNAs in the KRAS Pathway and Cancer DOI
Mudasir Maqbool, Md Sadique Hussain, Ajay Singh Bisht

et al.

Pathology - Research and Practice, Journal Year: 2024, Volume and Issue: 262, P. 155570 - 155570

Published: Aug. 29, 2024

Language: Английский

Citations

10
Long non-coding RNAs in cancer: multifaceted roles and potential targets for immunotherapy DOI
Lokesh Kadian, Deepika Verma, Neelam Lohani

et al.

Molecular and Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 479(12), P. 3229 - 3254

Published: Feb. 28, 2024

Language: Английский

Citations

9
CD58 Immunobiology at a Glance DOI Creative Commons
Yalu Zhang, Qiaofei Liu, Sen Yang

et al.

Frontiers in Immunology, Journal Year: 2021, Volume and Issue: 12

Published: June 8, 2021

The glycoprotein CD58, also known as lymphocyte-function antigen 3 (LFA-3), is a costimulatory receptor distributed on broad range of human tissue cells. Its natural ligand CD2 primarily expressed the surface T/NK CD2-CD58 interaction an important component immunological synapse (IS) that induces activation and proliferation cells triggers series intracellular signaling in target cells, respectively, addition to promoting cell adhesion recognition. Furthermore, soluble form CD58 (sCD58) present cellular supernatant vitro local tissues vivo . sCD58 involved cell-mediated immune responses immunosuppressive factor by affecting interaction. Altered accumulation may lead immunosuppression tumor microenvironment, allowing novel immunotherapeutic target. Recently, crucial roles molecule immunomodulation seem be reattracting interests investigators. In particular, regulation antiviral responses, inflammatory autoimmune diseases, rejection transplantation, evasion this review, we provide comprehensive summary immunobiology.

Language: Английский

Citations

55
The Role of Long Non-Coding RNAs in the Tumor Immune Microenvironment DOI Creative Commons
Yingli Guo,

Yajuan Xie,

Yao Luo

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Feb. 9, 2022

Tumorigenesis is a complicated process caused by successive genetic and epigenetic alterations. The past decades demonstrated that the immune system affects tumorigenesis, tumor progression, metastasis. Although increasing immunotherapies are revealed, only tiny proportion of them effective. Long non-coding RNAs (lncRNAs) class single-stranded RNA molecules larger than 200 nucleotides essential in molecular network oncology immunology. Increasing researches have focused on connection between lncRNAs cancer immunotherapy. However, in-depth mechanisms still elusive. In this review, we outline latest studies functions microenvironment. Via participating various biological processes such as neutrophil recruitment, macrophage polarization, NK cells cytotoxicity, T functions, regulate invasion, epithelial-mesenchymal transition (EMT), angiogenesis. addition, reviewed current understanding relevant strategies for targeting lncRNAs. LncRNAs-based therapeutics may represent promising approaches serving prognostic biomarkers or potential therapeutic targets cancer, providing ideas future research clinical application diagnosis therapies.

Language: Английский

Citations

34