A novel insight into cancer therapy: Lipid metabolism in tumor-associated macrophages

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 135, P. 112319 - 112319

Published: May 26, 2024

The tumor immune microenvironment (TIME) can limit the effectiveness and often leads to significant side effects of conventional cancer therapies. Consequently, there is a growing interest in identifying novel targets enhance efficacy targeted therapy. More research indicates that tumor-associated macrophages (TAMs), originating from peripheral blood monocytes generated bone marrow myeloid progenitor cells, play crucial role (TME) are closely associated with resistance traditional Lipid metabolism alterations have been widely recognized as having impact on tumors their microenvironment. Lipids, lipid derivatives, key substances metabolic pathways influence carcinogenesis progression cells by modulating phenotype, function, activity TAMs. Therefore, this review focuses reprogramming microenvironment, which TAMs especially concentrated. Such changes activation polarization, thereby affecting cell response treatment. Furthermore, article explores potential targeting supplementary approach It reviews evaluates current strategies for enhancing through TAMs' proposes new synergistic options chemo-radiotherapy immunotherapy. These efforts aim stimulate further area.

Language: Английский

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Long Non-Coding RNA (lncRNA) in Oral Squamous Cell Carcinoma: Biological Function and Clinical Application

Cancers, Journal Year: 2021, Volume and Issue: 13(23), P. 5944 - 5944

Published: Nov. 26, 2021

Oral squamous cell carcinoma (OSCC) is a type of malignancy with high mortality, leading to poor prognosis worldwide. However, the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Recently, discovery and characterization long non-coding RNAs (lncRNAs) revealed their regulatory importance in OSCC. Abnormal expression lncRNAs has broadly implicated initiation progress tumors. In this review, we summarize functions regarding these addition, highlight crosstalk between lncRNA tumor microenvironment (TME), discuss potential applications as diagnostic prognostic tools therapeutic targets Notably, also lncRNA-targeted techniques including CRISPR-Cas9 well immune checkpoint therapies target PD-1/PD-L1 axis. Therefore, review presents future perspectives therapy, but more research needed allow findings clinic.

Language: Английский

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Targeting monocytes/macrophages in fibrosis and cancer diseases: Therapeutic approaches

Pharmacology & Therapeutics, Journal Year: 2021, Volume and Issue: 234, P. 108031 - 108031

Published: Nov. 11, 2021

Language: Английский

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(Dis)similarities between the Decidual and Tumor Microenvironment

Biomedicines, Journal Year: 2022, Volume and Issue: 10(5), P. 1065 - 1065

Published: May 4, 2022

Placenta-specific trophoblast and tumor cells exhibit many common characteristics. Trophoblast invade maternal tissues while being tolerated by the immune system. Similarly, can surrounding escape Importantly, both are supported an abetting microenvironment, which influences invasion, angiogenesis, tolerance/evasion, among others. However, in contrast to cells, metabolic, proliferative, migrative, invasive states of under tight regulatory control. In this review, we provide overview similarities dissimilarities processes that drive cell fate, particularly focusing on role microenvironments.

Language: Английский

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5-Methylcytosine Related LncRNAs Reveal Immune Characteristics, Predict Prognosis and Oncology Treatment Outcome in Lower-Grade Gliomas

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: March 3, 2022

5-Methylcytosine (m5C) methylation is an important RNA modification pattern that can participate in oncogenesis and progression of cancers by affecting stability, expression oncogenes, the activity cancer signaling pathways. Alterations long non-coding RNAs (lncRNAs) are potentially correlated with abnormalities m5C regulation features cancers. Our aim was to reveal mechanisms which lncRNAs regulated process, explore impact aberrant on biological properties lower-grade gliomas (LGG), optimize current therapeutic. By searching 1017 LGG samples from Cancer Genome Atlas Chinese Glioma Atlas, we first clarified potential regulators prognosis this study used univariate Cox analysis least absolute shrinkage selection operator regression clinically meaningful lncRNAs. Consequently, identified four lncRNAs, including LINC00265, CIRBP-AS1, GDNF-AS1, ZBTB20-AS4, established a novel m5C-related signature (m5CrLS) effective predicting prognosis. Notably, mutation rate, WHO class II, IDH mutation, 1p/19q co-deletion MGMT promoter were increased low m5CrLS score group. Patients scores mostly showed activation tumor malignancy-related pathways, immune infiltrating cells, decreased anti-tumor function. Besides, relatively high checkpoints also revealed immunosuppressed state patients scores. In particular, stratification sensitive assess efficacy temozolomide responsiveness checkpoint blockade. conclusion, our results molecular basis LGG, provided valuable clues for understanding filled gap between epigenetics microenvironment.

Language: Английский

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Bioinformatic Tools for the Analysis and Prediction of ncRNA Interactions

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(21), P. 11397 - 11397

Published: Oct. 22, 2021

Noncoding RNAs (ncRNAs) play prominent roles in the regulation of gene expression via their interactions with other biological molecules such as proteins and nucleic acids. Although much our knowledge about how these ncRNAs operate different processes has been obtained from experimental findings, computational biology can also clearly substantially boost this by suggesting possible novel molecules. Computational predictions are thus used an alternative source new insights through a process mutual enrichment because information experiments continuously feeds into methods. The results turn shed light on that subsequently validated experimentally. This review describes latest advances databases, bioinformatic tools, silico strategies allow establishment or prediction ncRNAs, particularly miRNAs lncRNAs. ncRNA species described work have special emphasis those found humans, but is included.

Language: Английский

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circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p

Translational Lung Cancer Research, Journal Year: 2021, Volume and Issue: 10(3), P. 1457 - 1473

Published: March 1, 2021

Background: As a type of non-coding RNA, circular RNAs (circRNAs) are considered to be functional molecules associated with human cancers. An increasing number circRNAs have been verified in malignant progression The circRNA, circFBXW7, has proven play an important role tumor proliferation and metastasis. However, whether circFBXW7 influences lung adenocarcinoma (LUAD) remains unclear.Methods: Quantitative real-time reverse transcriptase PCR (qRT-PCR) was used verify LUAD cell lines tissues. Kaplan-Meier analysis then compare the disease-free survival (DFS) overall (OS) these patients. biological function examined by overexpression knockdown using MTT assay, EdU wound-healing Transwell vitro assays. To explore mechanism RNA pull-down dual luciferase reporter immunoprecipitation (RIP) assay were employed examine interaction between miR-942-5p. Western blot study fundamental proteins epithelial-mesenchymal transition (EMT) pathway. In vivo studies BALB/c nude mice subcutaneously injected cells stably overexpressing performed further validate results.Results: downregulated tissues, patients lower levels had shorter DFS OS. showed that inhibited migration A549 HCC2279 lines. These results confirmed knockdown, which effect. model circRNA influenced growth. Finally, we determined target miRNA-942-5p regulates EMT gene BARX2. modulation produced significant changes genes vivo.Conclusions: Our findings inhibits controlling miR-942-5p/BARX2 axis its correlates patient suggesting regulating could therapeutic value treating

Language: Английский

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Noncoding RNAs as sensors of tumor microenvironmental stress

Journal of Experimental & Clinical Cancer Research, Journal Year: 2022, Volume and Issue: 41(1)

Published: July 16, 2022

Abstract The tumor microenvironment (TME) has been demonstrated to modulate the biological behavior of tumors intensively. Multiple stress conditions are widely observed in TME many cancer types, such as hypoxia, inflammation, and nutrient deprivation. Recently, accumulating evidence demonstrates that expression levels noncoding RNAs (ncRNAs) dramatically altered by stress, dysregulated ncRNAs can turn regulate cell proliferation, metastasis, drug resistance. In this review, we elaborate on signal transduction pathways or epigenetic which hypoxia-inducible factors (HIFs), inflammatory factors, deprivation ncRNAs, highlight pivotal roles stress-related tumors. This helps clarify molecular regulatory networks between may provide potential targets for therapy.

Language: Английский

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Extracellular vesicles in gastric cancer: role of exosomal lncRNA and microRNA as diagnostic and therapeutic targets

Frontiers in Physiology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 16, 2023

Extracellular vesicles (EVs), including exosomes, play a crucial role in intercellular communication and have emerged as important mediators the development progression of gastric cancer. This review discusses current understanding EVs, particularly exosomal lncRNA microRNA, cancer their potential diagnostic therapeutic targets. Exosomes are small membrane-bound particles secreted by both cells stromal within tumor microenvironment. They contain various ncRNA biomolecules, which can be transferred to recipient promote growth metastasis. In this review, we highlighted importance microRNA Exosomal lncRNAs been shown regulate gene expression interacting with transcription factors or chromatin-modifying enzymes, binding target mRNAs. We also discuss use microRNAs biomarkers for isolated from bodily fluids, blood, urine, saliva. specific molecules that reflect molecular characteristics tumor, making them promising candidates non-invasive tests. Finally, targeting strategy were reviewed wee. Inhibition exosomes has suppress metastasis preclinical models. conclusion, article provides an overview suggest further research into these could lead new tools strategies deadly disease.

Language: Английский

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The Role of ncRNAs in the Immune Dysregulation of Preeclampsia

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(20), P. 15215 - 15215

Published: Oct. 16, 2023

The main complications causing practically 75% of all maternal deaths are severe bleeding, infections, and high blood pressure during pregnancy (preeclampsia (PE) eclampsia). usefulness ncRNAs as clinical biomarkers has been explored in an extensive range human diseases including pregnancy-related such PE. Immunological dysregulation show that the Th1/17:Th2/Treg ratio is “central causal” to However, there evidence involvement placenta-expressed miRNAs lncRNAs immunological regulation crucial processes placenta development function pregnancy. Abnormal expression these molecules related immune physiopathological occur Therefore, this work aims describe importance Interestingly, multiple ncRNAS involved PE participating type 1 response regulation, microenvironment promoting inflammatory factors, trophoblast cell invasion women with Early-Onset (EOPE), placental development, angiogenesis, promotion population M1 M2, proliferation, invasion, migration cells, autophagy through vias PI3K/AKT/mTOR, VEGF/VEGFR1, TLR9/STAT3.

Language: Английский

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