Molecular and Cellular Probes, Journal Year: 2024, Volume and Issue: 78, P. 101984 - 101984
Published: Oct. 10, 2024
Language: Английский
Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(2), P. 547 - 559
Published: Jan. 11, 2024
A non-negligible part of our DNA has been proven to be transcribed into non-protein coding RNA and its intricate involvement in several physiological processes highly evidenced. The significant biological role non-coding RNAs (ncRNAs), including long (lncRNAs) variously reported. In the current review, authors highlight multifaceted myocardial infarction-associated transcript (
Language: Английский
Citations
11
Briefings in Bioinformatics, Journal Year: 2022, Volume and Issue: 23(6)
Published: Aug. 29, 2022
In recent years, many studies have illustrated the significant role that non-coding RNA (ncRNA) plays in biological activities, which lncRNA, miRNA and especially their interactions been proved to affect processes. Some silico methods proposed applied identify novel lncRNA-miRNA (LMIs), but there are still imperfections representation information extraction approaches, imply is room for further improving performances. Meanwhile, only a few of them accessible at present, limits practical applications. The construction new tool LMI prediction thus imperative better understanding relevant mechanisms. This study method, ncRNAInter, prediction. A comprehensive strategy an optimized deep learning algorithm graph neural network were utilized this study. ncRNAInter was robust showed performance 26.7% higher Matthews correlation coefficient than existing reputable human addition, its universal applicability dealing with LMIs from various species successfully identified associated diseases, verified effectiveness usability. All source code datasets freely available https://github.com/idrblab/ncRNAInter.
Language: Английский
Citations
29
International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(7), P. 3695 - 3695
Published: March 28, 2022
Plant transcriptomes encompass a large number of functional non-coding RNAs (ncRNAs), only some which have protein-coding capacity. Since their initial discovery, ncRNAs been classified into two broad categories based on biogenesis and mechanisms action, housekeeping regulatory ncRNAs. With advances in RNA sequencing technology computational methods, bioinformatics resources continue to emerge update rapidly, including workflow for silico ncRNA analysis, up-to-date platforms, databases, tools dedicated identification annotation. In this review, we aim describe the biogenesis, biological functions, interactions with DNA, RNA, protein, microorganism five major (miRNA, siRNA, tsRNA, circRNA, lncRNA) plants. Then, systematically summarize analysis prediction plant ncRNAs, as well databases. Furthermore, discuss process these present protocol step-by-step general, review will help researchers better understand world at multiple levels.
Language: Английский
Citations
27
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2636 - 2636
Published: Jan. 30, 2023
Age-related macular degeneration (AMD) is an ever-increasing, insidious disease which reduces the quality of life millions elderly people around world. AMD characterised by damage to retinal pigment epithelium (RPE) in macula region retina. The origins this multi-factorial are complex and still not fully understood. Oxidative stress mitochondrial imbalance RPE believed be important factors development AMD. In review, regulation function antioxidant response non-coding RNAs (ncRNAs), newly emerged epigenetic factors, discussed. These molecules include microRNAs, long RNAs, circular RNAs. They act mainly as mRNA suppressors, controllers other ncRNAs, or interacting with proteins. We here examples these RNA affect various processes signaling cell. As a future prospect, possibility manipulate ncRNAs strengthen functions Non-coding could used potential diagnostic markers for AMD, future, also therapeutic targets, either suppressing increasing their expression. addition it possible that regulators oxidative stress-related degenerative diseases.
Language: Английский
Citations
15
Aquaculture, Journal Year: 2024, Volume and Issue: 593, P. 741250 - 741250
Published: June 18, 2024
Language: Английский
Citations
5
Frontiers in Cell and Developmental Biology, Journal Year: 2022, Volume and Issue: 10
Published: March 28, 2022
Pyroptosis is a novel form of programmed cell death (PCD), which characterized by DNA fragmentation, chromatin condensation, swelling and leakage contents. The process pyroptosis performed certain inflammasome executor gasdermin family member. Previous researches have manifested that closely related to human diseases (such as inflammatory diseases) malignant tumors, while the regulation mechanism not yet clear. Non-coding RNA (ncRNA) such microRNA (miRNA), long non-coding (lncRNA) circular (circRNA) been widely identified in genome eukaryotes played paramount role development function fate after transcription. Accumulating evidences support importance ncRNA biology hallmarks pyroptosis. However, associations between are rarely reviewed. In this review, we trying summarize pyroptosis, provides new research direction ideas for study different diseases.
Language: Английский
Citations
22
Function, Journal Year: 2024, Volume and Issue: 5(2)
Published: Jan. 1, 2024
Abstract The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects such as bone density, structural integrity, regenerative processes, normal function. Autophagy, an intricate intracellular mechanism degrading recycling cellular components, plays a multifaceted role in metabolism. It involves sequestering waste, damaged proteins, organelles within autophagosomes, are then degraded recycled. Autophagy’s impact on health varies depending factors regulation, cell type, environmental cues, physiological context. Despite being traditionally considered cytoplasmic process, autophagy subject to transcriptional epigenetic regulation the nucleus. However, precise influence of including DNA methylation, histone modifications, non-coding RNA expression, fate remains incompletely understood. interplay between modifications adds complexity regulation. This article provides in-depth exploration these two regulatory paradigms, with focus control Such understanding enhances our knowledge metabolism-related disorders offers insights development targeted therapeutic strategies.
Language: Английский
Citations
4
ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(7), P. 1901 - 1915
Published: June 7, 2024
Non-coding RNAs are pivotal regulators of gene and protein expression, exerting crucial influences on diverse biological processes. Their dysregulation is frequently implicated in the onset progression diseases, notably cancer. A profound comprehension intricate mechanisms governing ncRNAs imperative for devising innovative therapeutic interventions against these debilitating conditions. Significantly, nearly 80% our genome comprises ncRNAs, underscoring their centrality cellular The elucidation ncRNA functions grasping complexities regulation its implications human health. Modern sequencing techniques yield vast datasets, stored specialized databases. To harness this wealth information to understand crosstalk non-coding RNAs, knowledge available databases required, many new sophisticated computational tools have emerged. These play a role identification, prediction, annotation thereby facilitating experimental validation. This Review succinctly outlines current understanding emphasizing involvement disease development. It also highlights instrumental classifying, annotating, evaluating ncRNAs. By extracting meaningful insights from seemingly "junk" data, empower scientists unravel roles shaping
Language: Английский
Citations
4
Published: Jan. 1, 2025
Language: Английский
Citations
0
Egyptian Journal of Medical Human Genetics, Journal Year: 2025, Volume and Issue: 26(1)
Published: March 22, 2025
Abstract Cancer remains a significant global health challenge, claiming numerous lives annually and posing complex hurdles in management. The disease's multifaceted nature, combined with disparities healthcare infrastructure socioeconomic factors worldwide, complicates effective treatment. With alarming mortality rates, there is an urgent need to enhance prevention early detection strategies. Early not only enables less invasive treatments but also improves the chances of successful recovery, highlighting importance proactive approaches. Lung cancer ranks highest followed by breast, prostate, colon cancers. often seen as both "genetic disease," involving gene mutations, "environmental influenced various environmental affecting expression. Metabolic alterations are hallmark cancer, disruptions cellular stability function significantly contribute its progression. Non-coding RNAs (ncRNAs) play crucial regulatory roles across cancers, diverse structures functions. They act oncogenes or tumor suppressors depending on type, intricately modulating genetic epigenetic processes. Recent studies challenge perception ncRNAs' insignificance, revealing their substantial impact mechanisms. Indeed, ncRNAs connect networks, influencing vital protein effectors that dictate responses fate. Consequently, dysregulated pivotal role disease pathogenesis, acting either oncogenic drivers through aberrant expression
Language: Английский
Citations
0