A Novel miR-98 Negatively Regulates the Resistance of Endometrial Cancer Cells to Paclitaxel by Suppressing ABCC10/MRP-7 DOI Creative Commons
Wei Huang, Jun Zhang, Biao Dong

et al.

Frontiers in Oncology, Journal Year: 2021, Volume and Issue: 11

Published: Dec. 7, 2021

Endometrial cancer (EC) is one of the most frequent gynecological tumors, and chemoresistance a major obstacle to improving prognosis EC patients. MicroRNAs (miRNAs) long non-coding RNAs (lncRNAs) have recently emerged as crucial regulators that alter levels downstream target genes. Multidrug Resistance Protein 7 (MRP-7/ABCC10) an ATP-binding cassette transporter causes resistance anti-cancer drugs. The purpose this research determine whether MRP-7 has role in mediating sensitivity cells paclitaxel expression regulated by miR-98 lncRNA NEAT1. We reported were significantly increased tissues associated with unfavorable prognosis. Downregulation sensitized these reduced cell invasion. PLAUR serves molecule facilitates invasiveness. Moreover, tumor suppressor inhibit expression, leading repression resistance. Furthermore, novel lncRNA, NEAT1, was identified miR-98, NEAT1 could upregulate reducing miR-98. Taken together, findings demonstrate upregulation downregulation important roles conferring cells. modulation molecules may help overcome against

Language: Английский

Energy metabolism in health and diseases DOI Creative Commons
Hui Liu, Shuo Wang, Jianhua Wang

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: Feb. 18, 2025

Language: Английский

Citations

7
LncRNA CCAT1 facilitates the progression of gastric cancer via PTBP1-mediated glycolysis enhancement DOI Creative Commons
Cong Zhang, Huixia Wang, Qingwei Liu

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: Sept. 23, 2023

Gastric cancer (GC) is one of the most prevalent malignant tumors digestive system. As a hallmark cancer, energy-related metabolic reprogramming manipulated by multiple factors, including long non-coding RNAs (lncRNAs). Notably, lncRNA CCAT1 has been identified as crucial regulator in tumor progression. Nevertheless, precise molecular mechanisms underlying involvement GC remain unclear. Gain- and loss-of-function experiments were performed to evaluate roles tumorigenesis glycolysis GC. Bioinformatics analyses mechanistic experiments, such mass spectrometry (MS), RNA-pulldown, RNA immunoprecipitation (RIP), employed reveal potential interacting protein elucidate regulatory mechanism glycolysis. Moreover, nude mice xenograft assay was used effect on cells vivo. In this study, we that expression significantly elevated tissues plasma exosomes patients, well cell lines. Functional showed knockdown resulted substantial decrease proliferation, migration invasion both vitro vivo through decreasing glycolytic enzymes rate. Conversely, overexpression exhibited contrasting effects. Mechanistically, interacted with PTBP1 effectively maintained its stability inhibiting ubiquitin-mediated degradation process. critical splicing factor, facilitated transition from PKM1 PKM2, thereby augmenting activity ultimately fostering progression Our findings demonstrate plays significant role promoting migration, PTBP1/PKM2/glycolysis pathway, thus suggesting CCAT1's biomarker therapeutic target for

Language: Английский

Citations

24
Targeting glycolysis for cancer therapy using drug delivery systems DOI
Yongzhuo Huang

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 353, P. 650 - 662

Published: Dec. 14, 2022

Language: Английский

Citations

28
Metabolic reprogramming and interventions in endometrial carcinoma DOI Open Access
Jiajia Li, Hongmei Yang, Lingyi Zhang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 161, P. 114526 - 114526

Published: March 16, 2023

Cancer cells are usually featured by metabolic adaptations that facilitate their growth, invasion, and metastasis. Thus, reprogramming of intracellular energy metabolism is currently one the hotspots in field cancer research. Whereas aerobic glycolysis (known as Warburg effect) has long been considered a dominant form cells, emerging evidence indicates other forms, especially oxidative phosphorylation (OXPHOS), may play critical role at least some types cancer. Of note, women with syndromes (MetS), including obesity, hyperglycemia, dyslipidemia, hypertension, have an increased risk developing endometrial carcinoma (EC), suggesting close link between EC. Interestingly, preferences vary among EC cell types, particularly stem chemotherapy-resistant cells. Currently, it commonly accepted main provider while OXPHOS reduced or impaired. Moreover, agents specifically targeting and/or pathways can inhibit tumor growth promote chemosensitization. For example, metformin weight control not only reduce incidence but also improve prognosis patients. In this review, we comprehensively overview current in-depth understanding relationship provide up-to-date insights into development novel therapies for auxiliary treatment combination chemotherapy EC, those resistant to conventional chemotherapy.

Language: Английский

Citations

21
Glucose metabolic reprogramming and its therapeutic potential in obesity-associated endometrial cancer DOI Creative Commons
Pengzhu Huang, Xiangqin Fan,

Hongfei Yu

et al.

Journal of Translational Medicine, Journal Year: 2023, Volume and Issue: 21(1)

Published: Feb. 7, 2023

Abstract Endometrial cancer (EC) is a common gynecological that endangers women health. Although substantial progresses of EC management have been achieved in recent years, the incidence still remains high. Obesity has phenomenon worldwide increases risk EC. However, mechanism associating obesity and not fully understood. Metabolic reprogramming as remarkable characteristic currently emerging. As primary factor metabolic syndrome, promotes insulin resistance, hyperinsulinemia hyperglycaemia. This disorder remodels systemic status, which related with poor prognosis. Glucose metabolism cells complex mediated by glycolysis mitochondria to ensure energy requirement. Factors affect glucose may an impact on initiation progression. In this study, we review only but also inherent tumor cell metabolism. particular, role regulation malignant properties will be focused. Understanding profile metabolism-associated provide novel perspective for treatment.

Language: Английский

Citations

16
A lncRNA Dleu2-encoded peptide relieves autoimmunity by facilitating Smad3-mediated Treg induction DOI Creative Commons
Sibei Tang,

Junxun Zhang,

Fangzhou Lou

et al.

EMBO Reports, Journal Year: 2024, Volume and Issue: 25(3), P. 1208 - 1232

Published: Jan. 30, 2024

Abstract Micropeptides encoded by short open reading frames (sORFs) within long noncoding RNAs (lncRNAs) are beginning to be discovered and characterized as regulators of biological pathological processes. Here, we find that lncRNA Dleu2 encodes a 17-amino-acid micropeptide, which name Dleu2-17aa, is abundantly expressed in T cells. Dleu2-17aa promotes inducible regulatory (iTreg) cell generation interacting with SMAD Family Member 3 (Smad3) enhancing its binding the Foxp3 conserved non-coding DNA sequence 1 (CNS1) region. Importantly, genetic deletion mice start codon mutation impairs iTreg worsens experimental autoimmune encephalomyelitis (EAE). Conversely, exogenous supplementation relieves EAE. Our findings demonstrate an indispensable role maintaining immune homeostasis suggest therapeutic applications for this peptide treating diseases.

Language: Английский

Citations

6
Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis DOI Open Access
Shuo Yu, Min Wang, Hang Zhang

et al.

Genes, Journal Year: 2021, Volume and Issue: 12(11), P. 1701 - 1701

Published: Oct. 26, 2021

Gemcitabine is the first-line treatment for patients with pancreatic cancer (PC), yet most develop resistance to gemcitabine. Recent studies showed that circular RNAs (circRNAs) have important regulatory roles in PC progression and chemoresistance. In this study, ability of circRNA circ_0092367 enhance gemcitabine efficacy was tested underlying molecular mechanism investigated. The expression levels circ_0092367, miR-1206, ESRP1 were measured using qRT-PCR experiments. effects on cell lines exposed examined by CCK-8 assays. We performed luciferase assays determine relationship between miR-1206 ESRP1. demonstrated significantly downregulated tissues lines, a high associated improved survival PC. Gain- loss-of-function revealed inhibited epithelial-mesenchymal transition (EMT) phenotypes sensitized cells vitro vivo. Cytoplasmic could directly repress thus upregulate ESRP1, thereby inhibiting EMT enhancing sensitivity treatment. Our findings show plays crucial role sensitizing modulating miR-1206/ESRP1 axis, highlighting its potential as valuable therapeutic target patients.

Language: Английский

Citations

39
Role of miR‑181a‑5p in cancer (Review) DOI Creative Commons
Junxin Li,

Jing Shen,

Yueshui Zhao

et al.

International Journal of Oncology, Journal Year: 2023, Volume and Issue: 63(4)

Published: Aug. 3, 2023

MicroRNAs (miRNAs) are non‑coding RNAs (ncRNAs) that can post‑transcriptionally suppress targeted genes. Dysregulated miRNAs associated with a variety of diseases. MiR‑181a‑5p is conserved miRNA the ability to regulate pathological processes, such as angiogenesis, inflammatory response and obesity. Numerous studies have demonstrated miR‑181a‑5p exerts regulatory influence on cancer development progression, acting an oncomiR or tumor inhibitor in various types by impacting multiple hallmarks tumor. Generally, binds target RNA sequences partial complementarity, resulting suppression genes miR‑181a‑5p. However, precise role remains incompletely understood. The present review aims provide comprehensive summary recent research miR‑181a‑5p, focusing its involvement different potential diagnostic prognostic biomarker, well function chemoresistance.

Language: Английский

Citations

14
The pharmacological and biological importance of EZH2 signaling in lung cancer DOI Open Access
Maliheh Entezari, Afshin Taheriazam, Mahshid Deldar Abad Paskeh

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 160, P. 114313 - 114313

Published: Feb. 3, 2023

Up to 18% of cancer-related deaths worldwide are attributed lung tumor and global burden this type cancer is ascending. Different factors responsible for development such as smoking, environmental genetic mutations. EZH2 a vital protein with catalytic activity belongs PCR2 family. has been implicated in regulating gene expression by binding promoter targets. The importance discussed current manuscript. Activation significantly elevates the proliferation rate cancer. Furthermore, metastasis associated molecular mechanisms including EMT undergo activation enhancing progression. response therapy can be diminished due upregulation. Since increases progression, anti-cancer agents suppressing its reduce malignancy. In spite significant effort understanding modulatory function on other pathways, it appears that also regulated controlled described review. Therefore, translating findings clinic improve treatment management patients.

Language: Английский

Citations

13
Long Non-Coding RNA TMPO-AS1 Promotes GLUT1-Mediated Glycolysis and Paclitaxel Resistance in Endometrial Cancer Cells by Interacting With miR-140 and miR-143 DOI Creative Commons
Peixin Dong,

Feng Wang,

Mohammad Taheri

et al.

Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12

Published: May 27, 2022

Increased glycolysis in tumor cells is frequently associated with drug resistance. Overexpression of glucose transporter-1 (GLUT1) promotes the Warburg effect and mediates chemoresistance various cancers. Aberrant GLUT1 expression considered as an essential early step development endometrial cancer (EC). However, its role EC upstream mechanisms underlying overexpression, remain undefined. Here, we demonstrated that was highly expressed tissues cell lines high poor prognosis patients. Both gain-of-function loss-of-function studies showed increased proliferation, invasion, glycolysis, while also making them resistant to paclitaxel. The long non-coding RNA TMPO-AS1 found be overexpressed negatively patient outcomes. RNA-immunoprecipitation luciferase reporter assays confirmed elevated by directly binding two critical suppressor microRNAs (miR-140 miR-143). Downregulation remarkably reduced paclitaxel resistance cells. This study established dysregulation TMPO-AS1-miR-140/miR-143 axis contributes up-regulating expression. Thus, inhibiting may prove beneficial overcoming glycolysis-induced patients EC.

Language: Английский

Citations

19