Role of exosomes in the development of the immune microenvironment in hepatocellular carcinoma DOI Creative Commons

Tanghua Li,

Jiapeng Jiao,

Haoteng Ke

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 29, 2023

Despite numerous improved treatment methods used in recent years, hepatocellular carcinoma (HCC) is still a disease with high mortality rate. Many studies have shown that immunotherapy has great potential for cancer treatment. Exosomes play significant role negatively regulating the immune system HCC. Understanding how these exosomes innate and adaptive immunity HCC can significantly improve immunotherapeutic effects on Further, engineered deliver different drugs RNA molecules to regulate microenvironment of by aforementioned pathway, thereby improving rate This study aimed declare development list could be clinical transformation therapy. These findings might beneficial patients.

Language: Английский

The significance of glycolysis in tumor progression and its relationship with the tumor microenvironment DOI Creative Commons

Daoying Zhou,

Zhen Duan,

Zhenyu Li

et al.

Frontiers in Pharmacology, Journal Year: 2022, Volume and Issue: 13

Published: Dec. 14, 2022

It is well known that tumor cells rely mainly on aerobic glycolysis for energy production even in the presence of oxygen, and a modulator tumorigenesis development. The microenvironment (TME) composed cells, various immune cytokines, extracellular matrix, among other factors, complex niche supporting survival development through which they interact co-evolve with cells. In recent years, there has been renewed interest TME. Many studies have found promotes growth, metastasis, chemoresistance, as inhibiting apoptosis addition, lactic acid, metabolite glycolysis, can also accumulate TME, leading to reduced pH immunosuppression, affecting This review discusses significance development, its association potential glycolysis-targeted therapies, provide new ideas clinical treatment tumors.

Language: Английский

Citations

89
Metabolic reprogramming in the tumor microenvironment of liver cancer DOI Creative Commons
Jian Lin, Dongning Rao, Mao Zhang

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 31, 2024

The liver is essential for metabolic homeostasis. onset of cancer often accompanied by dysregulated function, leading to rearrangements. Overwhelming evidence has illustrated that cellular metabolism can, in turn, promote anabolic growth and tumor propagation a hostile microenvironment. In addition supporting continuous survival, disrupted process also creates obstacles the anticancer immune response restrains durable clinical remission following immunotherapy. this review, we elucidate communication between cells their surrounding discuss how reprogramming impacts microenvironment efficacy We describe crucial role gut-liver axis remodeling crosstalk surveillance escape, highlighting novel therapeutic opportunities.

Language: Английский

Citations

44
Tissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets DOI Creative Commons

Fan Guan,

Ruixuan Wang,

Zhenjie Yi

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)

Published: March 7, 2025

Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.

Language: Английский

Citations

4
Extracellular vesicles in tumor immunity: mechanisms and novel insights DOI Creative Commons

Liwen Kuang,

Lei Wu, Yongsheng Li

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Feb. 14, 2025

Extracellular vesicles (EVs), nanoscale secreted by cells, have attracted considerable attention in recent years due to their role tumor immunomodulation. These facilitate intercellular communication transporting proteins, nucleic acids, and other biologically active substances, they exhibit a dual development immune evasion mechanisms. Specifically, EVs can assist cells evading surveillance attack impairing cell function or modulating immunosuppressive pathways, thereby promoting progression metastasis. Conversely, also transport release immunomodulatory factors that stimulate the activation regulation of system, enhancing body's capacity combat malignant diseases. This functionality presents promising avenues targets for immunotherapy. By examining biological characteristics influence on immunity, novel therapeutic strategies be developed improve efficacy relevance cancer treatment. review delineates complex immunomodulation explores potential implications approaches, aiming establish theoretical foundation provide practical insights advancement future EVs-based immunotherapy strategies.

Language: Английский

Citations

3
Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets DOI
Muath Suliman, Raed Obaid Saleh,

M Chandra

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 6, 2025

Language: Английский

Citations

2
Crosstalk between extracellular vesicles and tumor-associated macrophage in the tumor microenvironment DOI
Qiao Yi Chen, Beibei Gao,

Dongdong Tong

et al.

Cancer Letters, Journal Year: 2022, Volume and Issue: 552, P. 215979 - 215979

Published: Oct. 26, 2022

Language: Английский

Citations

41
Exosome derived from tumor-associated macrophages: biogenesis, functions, and therapeutic implications in human cancers DOI Creative Commons

Manli Zhou,

Xiaoyun He, Cheng Mei

et al.

Biomarker Research, Journal Year: 2023, Volume and Issue: 11(1)

Published: Nov. 19, 2023

Abstract Tumor-associated macrophages (TAMs), one of the most abundant immune cell types in tumor microenvironment (TME), account for approximately 50% local hematopoietic cells. TAMs play an important role tumorigenesis and development through crosstalk between various cells cytokines TME. Exosomes are small extracellular vesicles with a diameter 50–150 nm, that can transfer biological information (e.g., proteins, nucleic acids, lipids) from secretory to recipient circulatory system, thereby influencing progression human diseases, including cancer. Recent studies have suggested TAMs-derived exosomes crucial roles malignant proliferation, invasion, metastasis, angiogenesis, responses, drug resistance, metabolic reprogramming. potential be targeted therapy. In addition, abnormal expression non-coding RNAs proteins is closely related clinicopathological features patients cancer, these expected become new liquid biopsy markers early diagnosis, prognosis, monitoring tumors. this review, we explored provide diagnostic biomarkers therapeutic targets cancer prevention.

Language: Английский

Citations

34
M1 Macrophage-Derived Exosome LncRNA PVT1 Promotes Inflammation and Pyroptosis of Vascular Smooth Muscle Cells in Abdominal Aortic Aneurysm by Inhibiting miR-186-5p and Regulating HMGB1 DOI Creative Commons
Jinhui Zhang, Xili Zhang,

Xunqiang Liu

et al.

Cardiovascular Toxicology, Journal Year: 2024, Volume and Issue: 24(3), P. 302 - 320

Published: March 1, 2024

Abstract Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease. Vascular smooth muscle cells (VSMCs) are essential for maintaining the integrity of healthy blood vessels. Macrophages play an important role in inflammatory process AAA. However, effect macrophage-derived exosome LncRNA PVT1 on VSMCs unclear. Exosomes from M1 macrophages (M1φ-exos) were isolated and identified. The expression M1φ-exos was determined. AAA cell model constructed by treating with Ang-II. treated M1φ exosomes transfected si-LncRNA (M1φ si–LncRNA -exo). miR-186-5p mimic oe-HMGB1. Cell viability detected CCK-8. accumulation LDH ELISA. Western blot used to detect HMGB1, factors (IL-6, TNF-α IL-1β) pyroptosis-related proteins (GSDMD, N-GSDMD, ASC, NLRP3, Caspase-1 Cleaved-Capase-1). pyroptosis rate flow cytometry. At same time, targeting relationship between HMGB1 verified double fluorescein experiment. successfully extracted. significantly increased. M1φ-exo promotes inflammation VSMCs. si−LncRNA -exos inhibited can sponge regulate expression. MiR-186-5p further induced -exos. oe-HMGB1 could inhibit reversal mimic. secreted acting as ceRNA miR-186-5p, thereby promoting accelerating progression.

Language: Английский

Citations

14
M2 Tumor‐Associated Macrophages‐Derived Exosomal MALAT1 Promotes Glycolysis and Gastric Cancer Progression DOI
Yanzheng Wang, Jiahui Zhang, Hui Shi

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(24)

Published: April 19, 2024

Abstract M2‐polarized tumor‐associated macrophages (M2 TAMs) promote cancer progression. Exosomes mediate cellular communication in the tumor microenvironment (TME). However, roles of exosomes from M2 TAMs gastric progression are unclear. Herein, it is reported that TAMs‐derived induced aerobic glycolysis cells and enhanced their proliferation, metastasis, chemoresistance a glycolysis‐dependent manner. It identified MALAT1 (metastasis‐associated lung adenocarcinoma transcript 1) enriched TAM confirmed transfer to via mediates this effect. Mechanistically, interacted with δ‐catenin protein suppressed its ubiquitination degradation by β‐TRCP. In addition, upregulated HIF‐1α expression acting as sponge for miR‐217‐5p. The activation β‐catenin signaling pathways collectively led cells. Finally, dual‐targeted inhibition both exosome‐mediated delivery siRNA remarkably growth improved chemosensitivity mouse models. Taken together, these results suggest ‐mediated regulation glycolysis. findings offer potential target therapy.

Language: Английский

Citations

13
Biological impact and therapeutic implication of tumor-associated macrophages in hepatocellular carcinoma DOI Creative Commons
Deming Li, Ting Zhang, Ye Guo

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(7)

Published: July 12, 2024

The tumor microenvironment is a complex space comprised of normal, cancer and immune cells. macrophages are considered as the most abundant cells in their function tumorigenesis interesting. Macrophages can be present M1 M2 polarization that show anti-cancer oncogenic activities, respectively. Tumor-associated (TAMs) mainly have they increase due to secretion factors, cytokines affecting molecular pathways. Hepatocellular carcinoma (HCC) among predominant tumors liver spite understanding its pathogenesis, role progression still requires more attention. presence TAMs HCC causes an growth invasion one reasons induction glycolysis such metabolic reprogramming makes distinct from normal promotes malignancy. Since stimulates HCC, networks regulating conversion been highlighted moreover, drugs compounds with ability targeting suppressing phenotypes or at least activity utilized. aggressive behavior biological functions result development therapy resistance. provide cell-cell communication by secreting exosomes having various types biomolecules transfer change activity. Finally, non-coding RNA transcripts affect HCC.

Language: Английский

Citations

12