A complex systems approach to mosaic loss of the Y chromosome DOI
Xihan Guo, Xueqin Dai

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

Pathological mechanisms of kidney disease in ageing DOI
Takeshi Yamamoto, Yoshitaka Isaka

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: 20(9), P. 603 - 615

Published: July 18, 2024

Language: Английский

Citations

18
Mosaic loss of Y chromosome is associated with aging and epithelial injury in chronic kidney disease DOI Creative Commons
Parker C. Wilson, Amit Verma, Yasuhiro Yoshimura

et al.

Genome biology, Journal Year: 2024, Volume and Issue: 25(1)

Published: Jan. 29, 2024

Abstract Background Mosaic loss of Y chromosome (LOY) is the most common chromosomal alteration in aging men. Here, we use single-cell RNA and ATAC sequencing to show that LOY present kidney increases with age chronic disease. Results The likelihood a cell having varies depending on its location nephron. Cortical epithelial types have greater proportion than medullary or glomerular types, which may reflect their proliferative history. Proximal tubule cells are abundant type cortex susceptible hypoxic injury. A subset these acquires pro-inflammatory transcription chromatin accessibility profile associated expression HAVCR1 , VCAM1 PROM1 . These injured greatest presence predicts future function decline. Moreover, proximal more likely harbor additional large gains express pro-survival pathways. Spatial transcriptomics localizes pro-fibrotic microenvironment where they adopt secretory phenotype communicate infiltrating immune cells. Conclusions We hypothesize an indicator increased DNA damage potential marker cellular senescence can be applied datasets other tissues.

Language: Английский

Citations

10
The effects of loss of Y chromosome on male health DOI Creative Commons
Bożena Bruhn‐Olszewska,

Ellen Markljung,

Edyta Rychlicka-Buniowska

et al.

Nature Reviews Genetics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

1
Loss of the Y Chromosome: A Review of Molecular Mechanisms, Age Inference, and Implications for Men’s Health DOI Open Access
Itzae Adonaí Gutiérrez-Hurtado,

Astrid Desireé Sánchez-Méndez,

Denisse Stephania Becerra‐Loaiza

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(8), P. 4230 - 4230

Published: April 11, 2024

Until a few years ago, it was believed that the gradual mosaic loss of Y chromosome (mLOY) normal age-related process. However, is now known mLOY associated with wide variety pathologies in men, such as cardiovascular diseases, neurodegenerative disorders, and many types cancer. Nevertheless, mechanisms generate men have not been studied so far. This task great importance because will allow focusing on possible methods prophylaxis or therapy for diseases mLOY. On other hand, would better understanding marker inferring age male samples cases human identification. Due to above, this work, comprehensive review literature conducted, presenting most relevant information molecular by which generated, well its implications men's health use infer age.

Language: Английский

Citations

4
The Kidney Precision Medicine Project and Single-Cell Biology of the Injured Proximal Tubule DOI
Danielle Janosevic, Thomas De Luca, Michael T. Eadon

et al.

American Journal Of Pathology, Journal Year: 2024, Volume and Issue: 195(1), P. 7 - 22

Published: Sept. 26, 2024

Language: Английский

Citations

1
Attenuated NIX in impaired mitophagy contributes to exacerbating cellular senescence in experimental periodontitis under hyperglycemic conditions DOI Open Access

Danni Song,

Beibei Chen, Tianfan Cheng

et al.

FEBS Journal, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Premature accumulation of senescent cells results in tissue destruction, and it is one the potential primary mechanisms underlying accelerated progression diabetes periodontitis. However, whether this characterized phenomenon could account for periodontal pathogenesis under hyperglycemic conditions remains unclear. In study, we assessed phenotypic changes experimental periodontitis conditions. Next, investigated mitochondrial function mitophagy pathways cellular senescence vitro vivo. Our findings showed that significant occurred gingival tissues diabetic mice with increased expression senescence-related protein p21

Language: Английский

Citations

1
Association between mosaic loss of chromosome Y and pulmonary fibrosis susceptibility and severity DOI Open Access
Dapeng Wang, Niran Hadad, Samuel Moss

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: May 30, 2024

Background Pulmonary fibrosis (PF) is a rare lung disease with diverse pathogenesis and multiple interconnected underlying biological mechanisms. Mosaic loss of chromosome Y (mLOY) one the most common forms acquired abnormality in men, which has been reported to be associated increased risk various chronic progressive diseases including fibrotic diseases. However, exact role mLOY development PF remains elusive elucidated.

Language: Английский

Citations

0
The impact of mosaic loss of the Y chromosome (mLOY) in men of advanced age DOI

Farid Abou Abdallah,

Christine Abdel Massih,

Charbel Attieh

et al.

Biogerontology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 2, 2024

Language: Английский

Citations

0
A guide to studying 3D genome structure and dynamics in the kidney DOI
Brian J. Beliveau, Shreeram Akilesh

Nature Reviews Nephrology, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Language: Английский

Citations

0
A complex systems approach to mosaic loss of the Y chromosome DOI
Xihan Guo, Xueqin Dai

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Language: Английский

Citations

0