Molecular and Cellular Probes,
Journal Year:
2024,
Volume and Issue:
78, P. 101993 - 101993
Published: Dec. 1, 2024
The
prognosis
of
advanced
osteosarcoma
(OS)
has
remained
stagnant
in
last
decades,
requiring
the
identification
novel
therapeutic
targets.
Recently,
much
attention
was
paid
to
role
squalene
epoxidase
(SQLE),
a
rate-limiting
enzyme
cholesterol
metabolism,
field
oncology,
while
specific
SQLE
OS
not
been
sufficiently
elucidated.
present
study
aims
investigate
progression
and
explore
potential
mechanisms.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 10, 2024
Hepatocellular
carcinoma
(HCC)
is
a
significant
contributor
to
cancer-related
deaths
in
the
world.
The
development
and
progression
of
HCC
are
closely
correlated
with
abnormal
regulation
non-coding
RNAs
(ncRNAs),
such
as
microRNAs
(miRNAs),
long
(lncRNAs),
circular
(circRNAs).
Important
biological
pathways
cancer
biology,
cell
proliferation,
death,
metastasis,
impacted
by
these
ncRNAs,
which
modulate
gene
expression.
expression
raises
possibility
that
they
could
be
applied
new
biomarkers
for
diagnosis,
prognosis,
treatment
targets.
Furthermore,
controlling
genes,
miRNAs
can
function
either
tumor
suppressors
or
oncogenes.
On
other
hand,
lncRNAs
play
role
advancement
interacting
molecules
within
cell,
which,
turn,
affects
processes
chromatin
remodeling,
transcription,
post-transcriptional
processes.
importance
ncRNA-driven
regulatory
systems
being
highlighted
current
research,
sheds
light
on
behavior
therapy
response.
This
research
highlights
great
potential
ncRNAs
improve
patient
outcomes
this
difficult
disease
landscape
augmenting
present
methods
care
through
use
precision
medicine
approaches.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2597 - 2597
Published: Feb. 23, 2024
The
N6-methyladenosine
(M6A)
modification
is
the
most
common
internal
chemical
of
RNA
molecules
in
eukaryotes.
This
can
affect
mRNA
metabolism,
regulate
transcription,
nuclear
export,
splicing,
degradation,
and
translation,
significantly
impact
various
aspects
physiology
pathobiology.
Radiotherapy
method
tumor
treatment.
Different
intrinsic
cellular
mechanisms
response
cells
to
ionizing
radiation
(IR)
effectiveness
cancer
radiotherapy.
In
this
review,
we
summarize
discuss
recent
advances
understanding
roles
M6A
methylation
responses
radiation-induced
DNA
damage
determining
outcomes
Insights
into
biology
may
facilitate
improvement
therapeutic
strategies
for
radiotherapy
radioprotection
normal
tissues.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: Sept. 9, 2024
Ferroptosis
is
a
type
of
cell
death
that
plays
remarkable
role
in
the
growth
and
advancement
malignancies
including
hepatocellular
carcinoma
(HCC).
Non-coding
RNAs
(ncRNAs)
have
considerable
impact
on
HCC
by
functioning
as
either
oncogenes
or
suppressors.
Recent
research
has
demonstrated
non-coding
ability
to
control
ferroptosis
cells,
hence
impacting
tumors
resistance
these
cells
drugs.
Autophagy
mechanism
conserved
throughout
evolution
maintaining
balance
body
under
normal
settings.
Nevertheless,
occurrence
dysregulation
autophagy
evident
progression
various
human
disorders,
specifically
cancer.
dual
roles
cancer,
potentially
influencing
both
survival
death.
prevalent
kind
liver
genetic
mutations
changes
molecular
pathways
might
worsen
its
advancement.
The
subject
debate,
it
capacity
repress
promote
tumor
growth.
activation
can
apoptosis,
proliferation
glucose
metabolism,
facilitate
spread
through
EMT.
Inhibiting
hinder
enhance
respond
treatment.
regulated
several
signaling
pathways,
such
STAT3,
Wnt,
miRNAs,
lncRNAs,
circRNAs.
Utilizing
anticancer
drugs
target
may
advantageous
implications
for
efficacy
cancer
Molecular Biomedicine,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: March 18, 2025
Abstract
RNA
N6-methyladenosine
(m6A)
is
a
common
modification
in
eukaryotes,
and
its
abnormal
regulation
closely
related
to
cancer
progression.
Aerobic
glycolysis
main
way
for
cells
obtain
energy.
It
was
found
that
beaded
filament
structural
protein
1
(BFSP1)
m6A
gene
liver
cancer.
However,
the
effect
of
m6A-modified
BFSP1
on
aerobic
how
it
regulated
progression
have
not
been
explored.
Here,
we
upregulated
tissues.
Overexpression
promoted
viability,
invasion,
cells,
whereas
knockdown
showed
opposite
effects.
Co-immunoprecipitation,
immunofluorescence
GST
pull
down
analyses
directly
interacted
with
tropomodalin
4
(TMOD4),
TMOD4
reversed
overexpression-induced
malignant
phenotypes
cells.
Moreover,
methyltransferase-like
3
(METTL3)
enhanced
stability
by
augmenting
mRNA,
which
achieved
YTHDF1-dependent
manner.
In
vivo
experiments
mice
confirmed
METTL3
increased
promoting
inhibited
tumor
growth
metastasis.
summary,
METTL3-mediated
methylation
mRNA
plays
an
important
role
cancer,
providing
potential
therapeutic
strategy
Thoracic Cancer,
Journal Year:
2024,
Volume and Issue:
15(18), P. 1397 - 1409
Published: May 8, 2024
Abstract
Background
Alterations
in
epigenetic
factors
are
recognized
as
key
contributors
to
the
emergence
of
human
cancer.
The
active
and
reversible
alteration
N6‐methyladenosine
(m6A)
RNA
is
crucial
for
controlling
gene
activity
determining
cellular
destiny.
Even
with
these
insights,
triggering
KIAA1429
(also
called
VIRMA)
its
role
lung
adenocarcinoma
(LUAD)
mostly
unclear.
As
a
result,
objective
this
study
was
elucidate
how
contributes
cancer
development
LUAD.
Methods
This
utilized
multiple
methods
investigation,
encompassing
vitro
functional
examination
cells,
transcriptome
sequencing,
methylation
immunoprecipitation
sequencing
(MeRIP‐seq),
well
stability
tests
ascertain
half‐life
target
genes.
Results
results
indicated
that
modifying
expression
regulated
proliferation
metastasis
By
employing
alongside
MeRIP‐seq
analysis,
research
pinpointed
genes
affected
by
m6A
alterations
triggered
KIAA1429.
In
more
detailed
manner,
it
discovered
plays
regulatory
ARHGAP30.
Suppressing
reduced
levels
mRNA
ARHGAP30,
boosting
expression,
thus
inhibiting
tumor
metastasis.
Conclusion
revealed
activation
mechanism
pivotal
function
LUAD
development,
paving
way
molecular‐based
interventions
Oncology Reports,
Journal Year:
2024,
Volume and Issue:
52(6)
Published: Oct. 8, 2024
Collagen
type
X
α1
chain
(COL10A1),
a
gene
encoding
the
α‑1
of
collagen,
serves
key
role
in
conferring
tensile
strength
and
structural
integrity
to
tissues.
Upregulation
COL10A1
expression
has
been
observed
different
malignancies,
including
lung,
gastric
pancreatic
cancer,
is
associated
with
poor
prognosis.
The
present
review
provides
an
updated
synthesis
evolving
biological
understanding
COL10A1,
particular
focus
on
its
mechanisms
action
regulatory
functions
within
context
tumorigenesis.
For
example,
it
established
that
increased
promotes
cancer
progression
by
activating
multiple
signaling
pathways,
TGF‑β1/Smad,
MEK/ERK
focal
adhesion
kinase
thereby
inducing
proliferation,
invasion
migration.
Additionally,
demonstrated
induce
epithelial‑mesenchymal
transition
reshapes
extracellular
matrix
tumor
Furthermore,
basis
methyltransferase‑like
3‑mediated
N6‑methyladenosine
methylation,
intricately
regulates
epitranscriptomic
machinery,
augmenting
oncogenic
role.
However,
although
pivotal
transcription
orchestration
growth,
question
whether
would
serve
as
viable
therapeutic
target
remains
subject
scientific
hypothesis
requiring
rigorous
examination.
Variables
such
distinct
microenvironments
treatment
associations
necessitate
further
experimental
validation.
Therefore,
comprehensive
assessment
functional
mechanistic
roles
may
pave
way
for
development
innovative
strategies.
N6-methyladenosine
(M6A)
modification
is
the
most
abundant
internal
chemical
on
RNA
molecules
in
eukaryotes
and
can
affect
mRNA
metabolism
regulate
transcription,
nuclear
export,
splicing,
degradation,
translation,
ets,
has
a
significant
impact
various
aspects
of
physiology
or
pathobiology.
Radiotherapy
common
measure
tumor
treatment,
variety
cellular
intrinsic
mechanisms
responses
cells
to
ionizing
radiation
(IR)
effectiveness
cancer
radiotherapy.
In
this
review,
we
summarize
discuss
recent
advances
about
roles
M6A
methylation
radiation-induced
DNA
damage
response,
outcomes
Insights
into
biology
may
facilitate
improvement
therapeutic
strategies
for
radiotherapy
as
well
radioprotection
normal
tissues.
