CytoJournal, Journal Year: 2024, Volume and Issue: 21, P. 53 - 53
Published: Nov. 25, 2024
Long non-coding RNAs (lncRNAs) participate in the formation, progression, and metastasis of cancer. This study aimed to explore roles lncRNA ST8SIA6 antisense RNA 1 (ST8SIA6-AS1) tumorigenesis elucidate underlying molecular mechanism its upregulation hepatocellular carcinoma (HCC).
Language: Английский
Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)
Published: Nov. 26, 2024
Epigenetics governs a chromatin state regulatory system through five key mechanisms: DNA modification, histone RNA remodeling, and non-coding regulation. These mechanisms their associated enzymes convey genetic information independently of base sequences, playing essential roles in organismal development homeostasis. Conversely, disruptions epigenetic landscapes critically influence the pathogenesis various human diseases. This understanding has laid robust theoretical groundwork for developing drugs that target epigenetics-modifying pathological conditions. Over past two decades, growing array small molecule targeting such as methyltransferase, deacetylase, isocitrate dehydrogenase, enhancer zeste homolog 2, have been thoroughly investigated implemented therapeutic options, particularly oncology. Additionally, numerous epigenetics-targeted are undergoing clinical trials, offering promising prospects benefits. review delineates epigenetics physiological contexts underscores pioneering studies on discovery implementation drugs. include inhibitors, agonists, degraders, multitarget agents, aiming to identify practical challenges avenues future research. Ultimately, this aims deepen epigenetics-oriented strategies further application settings.
Language: Английский
Citations
30
Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12
Published: Aug. 15, 2024
Liver cancer is one of the most lethal gastrointestinal malignancies. Emerging evidence has underscored pivotal role long non-coding RNAs (lncRNAs) in tumorigenesis, with ST8SIA6-AS1 identified as a novel oncogenic lncRNA contributing to liver progression. consistently upregulated hepatic tissues and strongly associated unfavorable prognosis. Moreover, it demonstrates high diagnostic efficacy detecting HCC. involved various cellular processes including proliferation, migration, invasion, primarily through its function competing endogenous RNA (ceRNA), thereby facilitating hepatocarcinogenesis disease advancement. This review provides detailed examination molecular functions regulatory mechanisms hepatocellular carcinoma (HCC) highlights potential promising biomarker for cancer, aiming propel development innovative therapeutic strategies HCC management.
Language: Английский
Citations
4
Journal of Hepatocellular Carcinoma, Journal Year: 2025, Volume and Issue: Volume 12, P. 539 - 552
Published: March 1, 2025
Background: Hepatocellular carcinoma (HCC) is a common malignancy with high recurrence rate following curative resection. This study aimed to identify factors contributing early (within 2 years) and develop Lasso-based nomogram for individualized risk assessment. Methods: We conducted retrospective analysis of 206 hCC patients who underwent resection at Taizhou Hospital, Zhejiang Province, from January 2019 August 2022. Patients were randomly divided into training (n=144) validation (n=62) cohorts. Lasso regression was used potential among 17 candidate predictors. A Cox proportional hazards model constructed based on variables selected by Lasso. Model performance assessed using receiver operating characteristic (ROC) curves, calibration plots, decision curve (DCA). Results: Five independent predictors HCC identified: age, serum alanine aminotransferase (ALT) levels, cirrhosis, tumor diameter, microvascular invasion (MVI). The demonstrated area under the (AUC) values recurrence-free survival (RFS) 0.828 (95% confidence interval [CI]: 0.753– 0.904) 1 year, 0.799 CI: 0.718– 0.880) years, 0.742 0.642– 0.842) 5 years in cohort. corresponding AUCs cohort 0.823 0.686– 0.960), 0.804 0.922), 0.857 0.722– 0.992) 1, respectively. Calibration curves DCA confirmed nomogram's accuracy clinical utility. Conclusion: Lasso-Cox effectively predicts within two post-hepatectomy, providing valuable tool personalized postoperative management improve patient outcomes. Keywords: hepatocellular carcinoma, invasion, recurrence, nomogram,
Language: Английский
Citations
0
Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown
Published: May 23, 2025
Abstract The most prevalent form of primary liver cancer and one the chief drivers cancer-related mortality globally is hepatocellular carcinoma (HCC). Imminent evidence has indicated that non-coding RNAs (ncRNAs) play an integral part in development propagation HCC. RNA stabilization, transcription regulation, chromatin genomic architecture remodeling, enhancer-associated activity, other varied properties set long intergenic ncRNA (lincRNA) genes apart from messenger (mRNA)-encoding genes. Through a variety processes, lincRNAs may generally be used to fine-tune nearby with exceptional tissue specificity, underscoring our quickly developing knowledge genome. their binding divergent cell targets, some HCC-related ncRNAs have been demonstrated exhibit abnormal expression, contribute malignant growth, evade apoptosis, invasive potential. Therefore, better comprehension lincRNA dysregulation might offer novel perspectives on pathophysiology HCC as well innovative instruments for early detection management In present review, we provide overview increasing relevance major contributor HCC, emphasizing influence signaling pathways implicated development, progression, response treatment tumors. addition, go over new approaches target possible therapeutic uses prognostic diagnostic biomarkers Graphical multifaceted roles (lincRNAs)
Language: Английский
Citations
0
Molecular Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: April 24, 2025
Language: Английский
Citations
0
Critical Reviews in Oncology/Hematology, Journal Year: 2025, Volume and Issue: unknown, P. 104773 - 104773
Published: May 1, 2025
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 4, 2024
Previous studies have demonstrated that genetic alterations governing epigenetic processes frequently drive tumor development and modifications in RNA may contribute to these alterations. In the 1970s, researchers discovered N6-methyladenosine (m
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 12235 - 12235
Published: Nov. 14, 2024
The increasing incidence of hepatocellular carcinoma (HCC), together with the poor effectiveness available treatments, make early diagnosis and effective screening utmost relevance. Liquid biopsy represents a potential novel approach to HCC detection monitoring. identification blood markers has many desirable features, including absence any significant risk for patients, possibility being used as tool, ability perform multiple tests, thus allowing real-time monitoring evolution. Unfortunately, have several limitations, mostly related specificity sensitivity. In this context, employing non-coding RNAs (ncRNAs) may represent an interesting diagnostic approach. ncRNAs, which include, among others, micro interfering (miRNAs), long (lncRNAs), circular (circRNAs), regulate human gene expression via interactions their target mRNA. Notably, can be altered in HCC, reflecting disease status. review, we discuss some notable works that describe use miRNAs, lncRNAs, circRNAs biomarkers. Despite open aspects ncRNA use, presented strongly support these molecules diagnostic/prognostic HCC.
Language: Английский
Citations
2
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 2, 2024
Most oncogenic genes contribute to cancer progression, but their role and regulatory mechanisms are not yet fully understood in hepatocellular carcinoma (HCC). This study aimed explore the of miR-328-3p relationship between HMOX1 HCC. We utilized Cox LASSO regression identify a panel associated with (HCC) progression within TCGA-LIHC cohort GSE104580 dataset. The expression levels hub gene, HMOX1, were assessed HCC cell lines using qPCR. functional roles evaluated through series vitro assays, including CCK-8 for proliferation, colony formation, wound healing, Transwell assays migration invasion. direct interaction was explored luciferase reporter assay, Western blot (WB) protein analysis, determine impact on proliferation migration. Eight candidate (BIRC5, TNSF4, SPP1, ADM, RBP2, IGF1, LECT2) screen out. gene among had high level lines. High expressing line significantly increased capacities. Moreover, identified as target miR-328-3p, which regulated qPCR WB assays. diminished capacities However, concurrent upregulation resulted enhanced proliferative migratory abilities these cells. Our has advanced our understanding HCC, demonstrating inhibitory effect activity HMOX1. Hence, results revealed function novel mechanistic pathway suggested potential therapeutic targeting intervention strategies.
Language: Английский
Citations
1
CytoJournal, Journal Year: 2024, Volume and Issue: 21, P. 53 - 53
Published: Nov. 25, 2024
Long non-coding RNAs (lncRNAs) participate in the formation, progression, and metastasis of cancer. This study aimed to explore roles lncRNA ST8SIA6 antisense RNA 1 (ST8SIA6-AS1) tumorigenesis elucidate underlying molecular mechanism its upregulation hepatocellular carcinoma (HCC).
Language: Английский
Citations
0