USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2 DOI Creative Commons
Nana Zhou, Chaoqin Guo, Xiangyu Li

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 229, P. 116473 - 116473

Published: Aug. 9, 2024

Ubiquitin-specific peptidase 24 (USP24), a member of the deubiquitinase family, plays an important role in tumor regulation. However, USP24 Hepatocellular carcinoma（HCC）is unknown. The aim our study was to explore HCC seek new therapeutic targets for HCC. In this study, we found that aberrantly upregulated tissues and predicted poor prognosis. markedly promoted proliferation progression vitro vivo. Mechanistically, binds necrosis factor receptor-associated 2(TRAF2) inhibits its degradation, thereby promoting accumulation TRAF2. Upregulation TRAF2 activated protein kinase B/nuclear kappa-B (AKT/ NF-κB) signaling pathway cell survival. addition, positively correlated with programmed death ligand 1(PD-L1) expression HCC, highlighting clinical significance activation immune evasion. Deletion enhanced tumor-killing ability CD8

Language: Английский

GluOC Induced SLC7A11 and SLC38A1 to Activate Redox Processes and Resist Ferroptosis in TNBC DOI Open Access

Jiaojiao Xu,

Xue Bai,

Keting Dong

et al.

Cancers, Journal Year: 2025, Volume and Issue: 17(5), P. 739 - 739

Published: Feb. 21, 2025

Background/Objectives: Ferroptosis, a type of programmed cell death, is mainly associated with disruptions in iron metabolism, imbalances the amino acid antioxidant system, and build-up lipid peroxides. Triple-negative breast cancer (TNBC) has dismal prognosis. Since activating ferroptosis can suppress proliferation, it holds promise as novel therapeutic target for patients. Thus, objective this study was to clarify mechanism TNBC, aiming find new treatment strategies TNBC Methods: We screened out differential genes related after GluOC based on whole-genome sequencing results. At cellular level, we conducted explorations using techniques such quantitative real-time polymerase chain reaction (qRT-PCR), Western blotting, fluorescence staining, siRNA transfection. Moreover, further verified role inhibiting through vivo experiments nude mice. Results: The results showed that enhanced glutathione expression levels by inducing SLC7A11 accumulation via specific signaling pathway. Additionally, increased ATP production tricarboxylic flux resistance SLC38A1. Overall, coordinately regulated SLC38A1 inhibit TNBC. Conclusions: This elucidated findings not only provided insights into but also potentially offered concepts development future anticancer therapies, which may contribute improving

Language: Английский

Citations

0
Sodium butyrate increases USP5-mediated ubiquitination degradation of GPX4 and enhances anti-cancer efficacy of anti-PD-1 antibody DOI

Qimeng Chang,

Huarong Mao,

Jin-Feng Feng

et al.

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116927 - 116927

Published: April 1, 2025

Language: Английский

Citations

0
A novel benzofuran derivative of β-elemene (ZT-22) inhibits hepatocellular carcinoma cell growth via directly targeting HSPA6 DOI
Zhiqiang Luo,

Huixia Fan,

Tao Zhang

et al.

Chemico-Biological Interactions, Journal Year: 2025, Volume and Issue: unknown, P. 111514 - 111514

Published: April 1, 2025

Language: Английский

Citations

0
The deubiquitinase OTUD5 stabilizes SLC7A11 to promote progression and reduce paclitaxel sensitivity in triple-negative breast cancer DOI
Xizhi Liu, Zhiqiang Ma, Xin Jing

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 604, P. 217232 - 217232

Published: Sept. 12, 2024

Language: Английский

Citations

3
Deubiquitinases as novel therapeutic targets for diseases DOI Creative Commons

Yali Xian,

Jing Ye,

Yu Tang

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(12)

Published: Dec. 1, 2024

Deubiquitinating enzymes (DUBs) regulate substrate ubiquitination by removing ubiquitin or cleaving within chains, thereby maintaining cellular homeostasis. Approximately 100 DUBs in humans counteract E3 ligases, finely balancing and deubiquitination processes to maintain proteostasis respond various stimuli stresses. Given their role modulating levels of substrates, are increasingly linked human health disease. Here, we review the DUB family, highlighting distinctive structural characteristics chain-type specificities. We show that family members key signaling pathways, such as NF-κB, PI3K/Akt/mTOR, MAPK, play crucial roles tumorigenesis other diseases (neurodegenerative disorders, cardiovascular diseases, inflammatory developmental diseases), making them promising therapeutic targets Our also discusses challenges developing inhibitors underscores critical cancer. This comprehensive analysis enhances our understanding complex biological functions potential.

Language: Английский

Citations

3
USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2 DOI Creative Commons
Nana Zhou, Chaoqin Guo, Xiangyu Li

et al.

Biochemical Pharmacology, Journal Year: 2024, Volume and Issue: 229, P. 116473 - 116473

Published: Aug. 9, 2024

Ubiquitin-specific peptidase 24 (USP24), a member of the deubiquitinase family, plays an important role in tumor regulation. However, USP24 Hepatocellular carcinoma（HCC）is unknown. The aim our study was to explore HCC seek new therapeutic targets for HCC. In this study, we found that aberrantly upregulated tissues and predicted poor prognosis. markedly promoted proliferation progression vitro vivo. Mechanistically, binds necrosis factor receptor-associated 2(TRAF2) inhibits its degradation, thereby promoting accumulation TRAF2. Upregulation TRAF2 activated protein kinase B/nuclear kappa-B (AKT/ NF-κB) signaling pathway cell survival. addition, positively correlated with programmed death ligand 1(PD-L1) expression HCC, highlighting clinical significance activation immune evasion. Deletion enhanced tumor-killing ability CD8

Language: Английский

Citations

1