The biological roles and molecular mechanisms of m6A reader IGF2BP1 in the hallmarks of cancer

Genes & Diseases, Journal Year: 2025, Volume and Issue: unknown, P. 101567 - 101567

Published: Feb. 1, 2025

Language: Английский

Role of NEL‑like molecule‑1 in osteogenesis/chondrogenesis (Review)

International Journal of Molecular Medicine, Journal Year: 2024, Volume and Issue: 55(1)

Published: Oct. 23, 2024

A dynamic balance exists between osteogenesis and osteoclastogenesis in bone tissue, which can lead to several diseases, such as osteoporosis, osteoarthritis, necrosis defects, cases of insufficient or excessive osteoclastogenesis. NEL‑like molecule‑1 (NELL‑1) was first discovered 1999 an osteogenic factor that prevent treat diseases by increasing levels. To date, research has identified multiple signaling pathways involved improving Furthermore, apply NELL‑1 clinical practice, researchers have optimized its effect combining it with other molecules, changing molecular structure performing tissue engineering. Currently, on is gaining attention. In the near future, will definitely be applied practice eliminate diseases. Thus, present study provides a comprehensive review enhancing levels from perspectives mechanism, interactions molecules/cells, molecular‑level changes, applications engineering expression tumors, providing solid theoretical basis for application.

Language: Английский

Insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) in hematological diseases

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Sept. 28, 2024

Language: Английский