Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(4)
Published: Nov. 6, 2024
Cancer
remains
one
of
the
most
challenging
health
issues
globally,
demanding
innovative
therapeutic
approaches
for
effective
treatment.
Nanoparticles,
particularly
those
composed
gold,
silver,
and
iron
oxide,
have
emerged
as
promising
candidates
changing
cancer
therapy.
This
comprehensive
review
demonstrates
landscape
nanoparticle-based
oncological
interventions,
focusing
on
remarkable
advancements
potentials
oxide
nanoparticles.
Gold
nanoparticles
garnered
significant
attention
their
exceptional
biocompatibility,
tunable
surface
chemistry,
distinctive
optical
properties,
rendering
them
ideal
various
diagnostic
strategies.
Silver
nanoparticles,
renowned
antimicrobial
exhibit
potential
in
therapy
through
multiple
mechanisms,
including
apoptosis
induction,
angiogenesis
inhibition,
drug
delivery
enhancement.
With
magnetic
properties
offer
unique
diagnosis
targeted
opportunities.
critically
examines
recent
synthesis,
functionalization,
biomedical
applications
these
Moreover,
challenges
are
discussed,
toxicity
concerns,
immunogenicity,
translational
barriers,
ongoing
efforts
to
overcome
hurdles
highlighted.
Finally,
insights
into
future
directions
regulatory
considerations,
provided
aiming
accelerate
translation
technologies
from
bench
bedside.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: March 13, 2025
The
latest
research
on
nanotechnology
through
the
new
tailored
scaffolds
encompassed
therapeutic
effects
of
natural
compounds,
and
unique
properties
metallic
nanoparticles
offer
possibilities
in
emerging
biomedical
fields.
Various
strategies
have
been
developed
to
address
limitations
existing
agents
concerning
specificity,
vectorization,
bioavailability,
drug
resistance,
adverse
effects.
In
this
study,
medicinal
plant
Portulaca
oleracea
L.
magnetite
were
used
develop
an
innovative
target
carrier
system,
designed
enhance
cytotoxic
effect
overcome
main
drawbacks
(permeability
localization)
phytoconstituents.
low-metabolite
profile
Romanian
wild-grown
exhibits
a
diverse
range
hundred
fifty-five
compounds
across
various
chemical
categories
(amino
acids,
peptides,
fatty
flavonoids,
alkaloids,
terpenoids,
phenolic
organic
esters,
sterols,
coumarins,
nucleosides,
lignans,
miscellaneous
compounds).
Morpho-structural
magnetic
phytocarrier
investigated
using
variety
methods,
including
XRD,
FTIR,
Raman,
SEM,
DLS),
determinations.
MTT
assay
was
conducted
evaluate
vitro
potential
cytotoxicity
normal
human
dermal
fibroblasts
(NHDF),
as
well
two
tumoral
cell
lines:
osteosarcoma
(HOS)
cervical
cancer
(HeLa).
Results
indicated
that
significant
inhibition
both
lines'
viability
exerted
by
compared
herbal
extract.
Furthermore,
results
obtained
for
total
content
antioxidant
screening
performed
FRAP
DPPH
assays
superior
system.
These
findings
suggest
applications
system
its
promising
implications
future
development
field.
Journal of Materials Chemistry B,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Ti
3
C
2
(O,Cl)
MXene,
synthesized
from
AlC
in
73.7%
yield,
exhibits
selective
cytotoxicity
vs.
FaDu
and
MCF-7
cancer
cell
lines
triggers
high
ROS
generation
cells
via
oxygen-rich
surface
terminations,
driving
targeted
oxidative
damage.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: May 20, 2025
Finding
the
molecular
targets
involved
in
severity
and
drug
resistance
of
Colorectal
cancer
(CRC)
applying
targeted
treatments
against
them
is
a
promising
approach.
In
this
study,
some
candidate
oncogenes
related
to
disease
mortality
were
identified
by
extracting
bioinformatics
data,
effect
Fe3O4@Glu-Cinnamon
NPs
on
survival
CRC
cells
(SW480)
expression
these
was
investigated.
The
characterized
FT-IR,
XRD,
DLS
zeta
potential
measurement,
TEM
SEM
imaging,
EDS-mapping
VSM
analysis.
Cytotoxicity
evaluated
MTT
assay
flow
cytometry
analysis
done
investigate
cell
apoptosis/necrosis
levels
cycle
cells.
with
spherical
morphology
correctly
synthesized,
containing
no
elemental
impurities,
size
range
26.8-60.2
nm,
213
-15.4mV
maximum
magnetization
level
20.33emu/g.
Treatment
elevated
primary
late
apoptosis
necrosis
20.85,
16.83
9.56%
treated
mainly
arrested
at
S
G2/M
phases.
associated
mortality,
SNAI1,
THBS2
INHBA
reduced
0.74,
0.66
0.7
folds,
respectively.
magnetic
properties
Fe3O4
enable
their
use
delivery,
allowing
for
site-specific
accumulation
within
tumors.
This
could
minimize
systemic
toxicity
while
enhancing
treatment
efficacy.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 13, 2025
The
current
chemotherapy
treatments
for
liver
cancer
have
shown
limited
effectiveness.
Therefore,
there
is
an
urgent
need
to
develop
new
drugs
combat
this
disease
more
effectively.
This
study
reports
synthesis
of
cobalt
oxide
nanoparticles
coated
with
glucose,
and
conjugated
Ellagic
acid.
Physicochemical
characterization
Co3O4@Glu-Ellagic
acid
was
done
using
FT-IR,
XRD,
SEM,
TEM,
TGA,
EDS-mapping,
DLS,
zeta
potential
analyses,
the
investigation
their
anticancer
on
cell
lines
involved
use
MTT,
flow
cytometry,
cycle
analysis.
synthesized
were
somewhat
spherical,
arranged
in
a
relatively
cluster-shaped
form,
33-46
nm
diameter.
particle
hydrodynamic
size
-
5.43
169
nm,
respectively
had
no
elemental
impurity.
Also,
particles
proper
thermal
stability
at
temperatures
below
100
°C.
Treating
cells
considerably
increased
ROS
levels
by
2.6
folds.
Compared
normal
human
cells,
showed
significantly
higher
toxicity
50%
inhibitory
concentration
94
187
µg/mL
respectively.
apoptosis,
from
0.87
9.24%,
mainly
arrested
G0/G1
G2/M
phases.
Overall,
present
work
indicated
that
has
antiproliferative
effects
through
oxidative
stress
level,
inhibition
cycle,
apoptosis
induction.
