A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1 DOI
Janina Deutschmann, Andreá Schneider, Iris Gruska

et al.

Nature Microbiology, Journal Year: 2019, Volume and Issue: 4(12), P. 2273 - 2284

Published: Sept. 23, 2019

Language: Английский

Mantle Transcriptome Provides Insights into Biomineralization and Growth Regulation in the Eastern Oyster (Crassostrea virginica) DOI
Dan Zeng, Ximing Guo

Marine Biotechnology, Journal Year: 2022, Volume and Issue: 24(1), P. 82 - 96

Published: Jan. 6, 2022

Language: Английский

Citations

16
Navigating the brain and aging: exploring the impact of transposable elements from health to disease DOI Creative Commons
Anna Le Breton,

Margarida P. Bettencourt,

Anne-Valérie Gendrel

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Feb. 27, 2024

Transposable elements (TEs) are mobile genetic that constitute on average 45% of mammalian genomes. Their presence and activity in genomes represent a major source variability. While this is an important driver genome evolution, TEs can also have deleterious effects their hosts. A growing number studies focused the role brain, both physiological pathological contexts. In believed to be for neuronal plasticity. neurological age-related disorders, aberrant may contribute disease etiology, although remains unclear. After providing comprehensive overview transposable interactions with host, review summarizes current understanding TE within during aging process, context conditions.

Language: Английский

Citations

3
SAMHD1 deficient human monocytes autonomously trigger type I interferon DOI Creative Commons
Alicia Martínez‐López, Marta Martín-Fernández, Sofija Buta

et al.

Molecular Immunology, Journal Year: 2018, Volume and Issue: 101, P. 450 - 460

Published: Aug. 9, 2018

Language: Английский

Citations

24
LINE-1: an emerging initiator of cGAS-STING signalling and inflammation that is dysregulated in disease DOI Creative Commons
Sabateeshan Mathavarajah, Graham Dellaire

Biochemistry and Cell Biology, Journal Year: 2023, Volume and Issue: 102(1), P. 38 - 46

Published: Aug. 29, 2023

The cGAS-STING (cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING)) axis integrates DNA damage and cellular stress with type I (IFN) signalling to facilitate transcriptional changes underlying inflammatory responses. pathway responds cytosolic in the form double-stranded DNA, micronuclei, long interspersed nuclear element 1 (L1) retroelements. L1 retroelements are a class self-propagating non-long terminal repeat transposons that have remained highly active mammalian genomes. emerging as important inducers IFN signalling, which often dysregulated several diseases, including cancer. A key repressor activity is exonuclease three prime repair (TREX1), loss TREX1 promotes accumulation L1. In addition, dysregulation common theme among diseases chronic induction through cGAS-STING, such Aicardi-Goutières syndrome, Fanconi anemia, dermatomyositis. Although conserved tetrapod species, other suppressor proteins exist inhibit retrotransposition. These when mutated associated characterized by unchecked inflammation high elevated levels expression. this review, we discuss these interconnected pathways suppression their role regulation disease.

Language: Английский

Citations

7
A viral kinase counteracts in vivo restriction of murine cytomegalovirus by SAMHD1 DOI
Janina Deutschmann, Andreá Schneider, Iris Gruska

et al.

Nature Microbiology, Journal Year: 2019, Volume and Issue: 4(12), P. 2273 - 2284

Published: Sept. 23, 2019

Language: Английский

Citations

22