Utilizing epigenetics to study the shared nature of development and biological aging across the lifespan

npj Science of Learning, Journal Year: 2024, Volume and Issue: 9(1)

Published: March 21, 2024

Recently, biological aging has been quantified in DNA-methylation samples of older adults and applied as so-called "methylation profile scores" (MPSs) separate target samples, including children. This nascent research indicates that (1) can be early the life course, decades before onset aging-related disease, (2) is affected by common environmental predictors childhood development, (3) shows overlap with "developmental processes" (e.g., puberty). Because MPSs were computed using algorithms developed adults, these studies indicate a molecular link between environments, adult aging. Yet, if used to connect development aging, previous only traveled one way, deriving applying them Researchers have not yet epigenetic measures reflect pace child tested whether resulting are associated physical psychological In this perspective I posit combining new quantifications power address fundamental questions about span: How experience related adulthood? And what aging?

Language: Английский

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Stability of Aging‐ and Cognition‐Related Methylation Profile Scores Across Two Waves in Children and Adolescents

Child Development, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

DNA-methylation profile scores (MPSs) index biology relevant for lifelong physical and cognitive health, but information on their longitudinal stability in childhood is lacking. Using two waves of data collected from 2014 to 2022 (Mlag between = 2.41 years) N 407 participants (Mage 12.05 years, 51% female, 60% White), test-retest correlations were estimated four salivary MPSs related aging (PhenoAgeAccel, GrimAgeAccel, DunedinPACE), function (Epigenetic-g). varied (test-retest rs 0.38 0.76). did not differ children exposed the COVID-19 pandemic, race-ethnic sex differences apparent. Further research necessary understand which environmental perturbations impact trajectories when are most sensitive those impacts.

Language: Английский

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Applying blood-derived epigenetic algorithms to saliva: cross-tissue similarity of DNA-methylation indices of aging, physiology, and cognition

Clinical Epigenetics, Journal Year: 2025, Volume and Issue: 17(1)

Published: April 23, 2025

Abstract Background Epigenetic algorithms of aging, health, and cognition, based on DNA-methylation (DNAm) patterns, are prominent tools for measuring biological age have been linked to age-related diseases, cognitive decline, mortality. While most these methylation profile scores (MPSs) developed in blood tissue, there is growing interest using less invasive tissues like saliva. The aim the current study probe cross-tissue intraclass correlation coefficients (ICCs) MPSs applied saliva DNAm from same people. our primary focus that were previously found be robustly correlated with social determinants including second- third-generation clocks physiology we also report ICC values first-generation enable comparison across metrics. We pooled three publicly available datasets had both individuals (total n = 107, aged 5–74 years), corrected cell composition within each computed ICCs. Results after correcting composition, saliva–blood ICCs moderate indices aging cognition. Specifically, PCGrimAge highest (0.76), followed by PCPhenoAge (0.72), a measure performance (Epigenetic- g , 0.69), DunedinPACE (0.68), Acceleration (0.67), (0.66), an MPS hs-CRP (0.58), BMI (0.54). These appear lower than previous reports within-tissue (saliva range 0.67 0.85, 0.73 0.93). Cross-tissue acceleration measures poor, ranging 0.19 0.25. Conclusions Our findings suggest applying related phenotypes results similarity precise correspondence differs measure. degree several may suffice some research settings, it not suitable clinical or commercial applications. Collection samples necessary validate existing customize DNAm.

Language: Английский

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Beyond a Shared History: A Biosocial Perspective on Sociogenomics and Racism in Germany

KZfSS Kölner Zeitschrift für Soziologie und Sozialpsychologie, Journal Year: 2024, Volume and Issue: 76(3), P. 573 - 602

Published: March 11, 2024

Abstract Recent advances in sociogenomics offer new opportunities to integrate genetic and epigenetic measures into social science research on human lifespan development. Now, German cohorts have followed suit with this global trend. We anticipate that the integration of is likely be met hesitation dismay. Historically, racialized pseudo-science disguised as was used justify political exploitation, oppression, genocide conducted by colonial Nazi Germany regimes. In response, institutions sciences actively avoided race-related research. However, avoiding intersection socially constructed race genetics may stall deconstruction enduring racial discrimination identification inequalities. survey studies show half population still believe existence biologically distinct “races” racism rampant. This article aimed at providing a biosocial perspective Germany. First, we discuss biologistic construction became prevalent argue racist legacies are sources inequality contemporary society. further review recent genomic clearly demonstrates there no biological basis race. Second, propose integrates how genes “get out skin” “gets under skin”. Transactional effects, which involve behavior interactions between people society, expected depend environmental inequalities tied systemic racism. summarize using polygenic indices profile scores showing a) contribute complex traits b) expression variation affected socioeconomic inequality. Finally, roadmap toward race-critical breaks historically informed avoidance reconstruct concepts, datasets, scientific systems.

Language: Английский

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No gene by stressful life events interaction on individual differences in adults’ self-control

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: April 17, 2024

Difficulty with self-control, or the ability to alter impulses and behavior in a goal-directed way, predicts interpersonal conflict, lower socioeconomic attainments, more adverse health outcomes. Etiological understanding, intervention for low self-control is, therefore, public goal. A prominent developmental theory proposes that individuals high genetic propensity are also exposed stressful environments may be most at-risk of levels self-control. Here we examine if polygenic measures associated behaviors marked by interact life events predicting

Language: Английский

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Stability of DNA-Methylation Profiles of Biological Aging in Children and Adolescents

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 1, 2023

Abstract Background and Objectives Methylation profile scores (MPSs) index biological aging aging-related disease in adults are cross-sectionally associated with social determinants of health childhood. MPSs thus provide an opportunity to trace how biology responds environmental changes early life. Information regarding the stability life is currently lacking. Method We use longitudinal data from children adolescents ages 8-18 (N = 428, M age 12.15 years) Texas Twin Project. Participants contributed two waves salivary DNA-methylation (mean lag 3.94 years), which were used construct four reflecting multi-system physiological decline mortality risk (PhenoAgeAccel GrimAgeAccel), pace (DunedinPACE), cognitive function (Epigenetic- g ). Furthermore, we exploit variation among participants whether they exposed COVID-19 pandemic during course study participation, order test a historical period characterized by disruption might affect children’s MPSs. Results All showed moderate (test-retest r s 0.42, 0.44, 0.46, 0.51 for PhenoAgeAccel, GrimAgeAccel, Epigenetic- , DunedinPACE, respectively). No differences apparent between those whose second assessment took place after onset vs. whom both assessments prior pandemic. Conclusions Aging-related patterns less stable childhood than has been previously observed adulthood. Further developmental research on methylome necessary understand perturbations impact trajectories when most sensitive impacts. Article Summary profiles What’s Known This Subject adulthood show very high test-retest but sparse. What Study Adds Children’s methylation moderately across approximately four-year period. adulthood, suggesting that be more responsive

Language: Английский

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Gambling-specific metacognitions, depression, and responsible gambling in Macao, China

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 370, P. 260 - 267

Published: Nov. 6, 2024

Language: Английский

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